Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 9299 for “"in vivo"”.
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Protein Semi-Synthesis in Vivo
<p>Incorporation of chemical probes into proteins is a powerful way to elucidate biological processes and to engineer novel function. This thesis describes the ligation of synthetic molecules to target proteins in an intracellular environment, and the use of semi-synthetic proteins for whole animal …
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Visualizing Dendritic Cells In Vivo
<p>Cell:cell interactions are critical at all stages of the immune response, yet relatively little is known about their dynamics in vivo. We set out to visualize in intact, living lymphoid tissue the physiological role of dendritic cells in tolerance and immunity; this was achieved by intravital …
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Examining cancer metabolism in vivo
… from those of most normal cells. Understanding these differences, and the factors that are responsible for creating different metabolic dependencies, is critical to understanding the basic requirements of rapid proliferation and identifying potential therapeutic vulnerabilities. In …
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High-Speed Photoacoustic Microscopy In Vivo
The overarching goal of this research is to develop a novel photoacoustic microscopy: PAM) technology capable of high-speed, high-resolution 3D imaging in vivo. PAM combines the advantages of optical absorption contrast and ultrasonic resolution for deep imaging beyond the quasi-ballistic regime. …
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Biomimetic sensor for in-vivo applications
… sensors) for the detection, diagnosis and monitoring of diseases, drug discovery, environmental detection of pollutants and/or biological agents has been an active area of research. A molecular sensor is a biomolecule or biomimetic molecule that performs two distinct functions in detecting target …
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Catalysis of tubulin heterodimerization in vivo
The heterodimerization of α- and β-tubulin represents a critical early step in microtubule morphogenesis. In vitro studies have defined a pathway that mediates the incorporation of monomeric tubulin polypeptides into heterodimer. The components of this pathway, tubulin cofactors, are dispensable …
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Engineering functional blood vessels in vivo
… present time, there are many hurdles to overcome in order to create a long-lasting and engineered tissue for tissue transplant in patients. The challenges include the isolation and expansion of appropriate cells, the arrangement of assorted cells into correct spatial organization, and the …
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Analysis of microtububule morphogenesis in vivo
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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A novel in vivo protein refolding technique
<p>Proteins perform their functions in their native folded states and misfolding of proteins may cause severe diseases, including Alzheimer's disease, Parkinson's disease, prion disease and diabetes. Understanding protein folding is important for us to engineer proteins to treat these diseases. For …
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In-Vivo Ct Dosimetry During Virtual Colonoscopy
<p>Virtual colonoscopy (VC) is a minimally invasive means for identifying colorectal polyps and colorectal lesions by insufflating a patient’s bowel, applying contrast agent via rectal catheter, and performing multi-detector computed tomography (MDCT) scans. The technique is recommended for colonic …
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Non-invasive in vivo ultrasound temperature estimation
New emerging technologies in thermal therapy require precise monitoring and control of the delivered thermal dose in a variety of situations. The therapeutic temperature changes in target tissues range from few degrees for releasing chemotherapy drugs encapsulated in the thermosensitive liposomes …
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In Vivo Forces of Male Urethral Catheterization
… study was to quantify typical urethral catheter insertion forces of male anatomy in vivo. This provided a quantitative range of forces that may be used to objectively evaluate trainees or educational simulators. A custom-made Handheld Catheter Insertion Force Assessment tool (+/- 0.29N accuracy) …
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Vergleichende Untersuchung verschiedener genetischer Impfstoffvektoren in vivo
… günstige Arzneimittel. Jedoch stehen für viele Infektionskrankheiten wie AIDS, Tuberkulose, Hepatitis C oder Malaria keine oder keine wirksamen Impfmöglichkeiten zur Verfügung. Um gegen intrazelluläre Erreger oder auch Tumore wirksam zu sein, muß ein potentieller Impstoff eine humorale und eine …
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ΡΙΤΟΔΡΙΝΗ ΚΑΙ ΕΝΔΟΚΥΤΤΩΣΗ (ΠΕΙΡΑΜΑΤΙΚΗ ΕΡΓΑΣΙΑ IN VIVO)
THE EFFECT OF RITODRINE ON THE PHAGOCYTIC ACTIVITY OF THE MONONUCLEAR PHAGOCYTES (M.P.S.) WAS STUDIED IN VIVO. THE CLEARANCE OF A CERTAIN QUANTITY OF CARBONPARTICLES (250A) FROM THE CIRCULATION WAS TAKEN AS AN INDICATOR OF THE PHAGOCYTIC ACTIVITY OF MPS ACCORDING TO THE METHOD PROPOSED BY HALPERN …
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Synaptic vesicle recycling <i>in Vivo</i>
Die Grundlagen der Reizweiterleitung an Synapsen sind prinzipiell gut verstanden: Wenn ein Aktionspotenzial die Synapse erreicht, induziert es einen Kalziumeinstrom, der wiederum zur Fusion synaptischer Vesikel mit der Plasmamembran führt, woraufhin die in den Vesikeln enthaltenen Neurotransmitter …
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Molecular mechanisms of neuronal homoeostasis in vivo
Homeostatic plasticity is important in neurobiology for stabilising neuronal networks in the face of Hebbian forms of synaptic plasticity that are thought to mediate memory storage. Impairment of homeostatic plasticity has also been implicated in neurological diseases such as Rett syndrome and …
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Microviscometric Analysis of Microvascular Hemodynamics in Vivo
Studies of blood flow in the microcirculation have been conducted for over a hundred years. Other than in 5--8 mum-diameter capillaries, where red cells travel in single-file flow, no method has been developed for either quantitatively predicting or accurately measuring the salient dynamic, …
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Plasmodium Gallinaceum in Vivo and in Vitro
The findings presented in this dissertation provide a more solid foundation for the comparison of avian malaria with falciparum malaria, and strengthen the rationale upon which to base development of attenuated live sporozoite vaccines for falciparum malaria.
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