Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"in vitro uptake"”.
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Synthesis, Characterization and Cellular Uptake of Magnesium Complexes of Pyrones and Amino Acids
… magnesium complexes (nutraceuticals) utilizing short-chain peptides (di- and tri-), pyrones, and amino acids. There is further emphasis placed on determining the in vitro uptake of all produced complexes. This work aims to mitigate the shortcomings of current magnesium supplements and better …
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Studies of Mammary Amino Acid Transport
… to study several different aspects of mammary amino acid transport. The experimental animals utilized were cow and rat. The major conclusions include the following: (1) Mammary tissue was shown to have relatively high (gamma)-glutamyl transpeptidase activity, and activity increased at the onset …
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Advances in DNA technology towards dynamic assemblies and biological applications
One of the major research aims in Materials Science and Engineering for the past two decades has pertained to the development of capabilities to manipulate and characterize materials on the molecular and atomic level. This capability has been largely driven by technological and engineering advances …
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The impact of hypoxia on nanomedicine uptake and efflux in human breast cancer cells
In women, breast cancer is the most frequently diagnosed neoplasm, with a recognised high mortality burden. Breast cancer cells adapt to the hypoxictumoral environment by undergoing changes in metabolism, cell signalling, endo-lysosomal receptor uptake and recycling. The resulting hypoxic …
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Evaluation of radiolabelled hynic-salmon calcitonin analogues as imaging agents for multiple myeloma and characterisation of novel hynic derivatives as chelators for technetium
Calcitonin is a peptide hormone produced by the C-cells of the thyroids. Calcitonin receptors (CTR) are expressed by osteoclasts in the normal bone and in many cancers such as multiple myeloma (MM), breast and prostate cancer. In this thesis we report on the synthesis and evaluation of Tc-99m …
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Identificazione di bersagli terapeutici e realizzazione di tecnologie innovative in oncologia ortopedica
… therapy of osteolytic bone metastases. Doxorubicin (DXR) is widely used in chemotherapy, although its activity is restricted by dose-dependent cardiotoxicity and marrow toxicity. However, its efficacy can be improved when specific targeting at the tumor site is obtained. The aim of this study was …
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Saturation and isomerization of dietary fatty acids influence nutrient absorption and metabolism in the chicken
… lipid sources on broiler chicken metabolism. In Experiment 1, the nitrogen-corrected apparent metabolizable energy values (AME<sub>n</sub>) of soybean oil (SBO) and hydrogenated soybean oil (HSBO) were determined. Trans monoenes, present only in HSBO, comprised 41% of total fatty acids. The …
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Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
Chemoreduction is the key treatment for retinoblastoma management. However, anticancer agents suffer from poor cell permeability and chemoresistance due to major interaction with multidrug resistant (MDR) efflux proteins (MDR1 and MRP2) over-expressed on retinoblastoma tumor. Ocular cells have …
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Evaluation of new PET tracers for receptor tumour imaging
PET imaging can be used to non-invasively characterise biological processes at the molecular and cellular levels. The oestrogen receptor (ER) and progesterone receptor (PR) are important biomarkers in the diagnosis, prognosis and follow-up of the therapeutic response of breast cancer. Determination …
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Uptake and transport of orally-deliverable drugs across caco-2 cell monolayers:the effect of lipid formulations
The aim of this thesis is to investigate the physicochemical parameters which can influence drug loading within liposomes and to characterise the effect such formulations have on drug uptake and transport across in vitro epithelial barrier models. Liposomes composed of phosphatidylcholine (PC) or …
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Thyroid hormone action and disruption in the brain: Xenopus as a model to study disruption of thyroid hormone availability on early brain development
Thyroid hormones (TH) are essential for normal brain development in vertebrates. Disruption of TH action, either due to genetic and/or environmental factors, has been implicated in neurological defects such as autism, attention deficit hyperactivity disorders (ADHD) and IQ loss. On average, over 30 …
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Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
PART I: SELF-ASSEMBLING TACROLIMUS NANOMICELLES FOR BACK OF THE EYE DISEASES Vrinda Gote, Candidate for the Doctor of Philosophy Degree University of Missouri-Kansas City, 2021 ABSTRACT Neovascular age-related macular degeneration (AMD) is characterized by increase in reactive oxygen species (ROS) …