Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"in vitro toxicology"”.
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In vitro toxicology of complex mixtures from drinking water disinfection and amine-based carbon capture systems
In nature, exposure to chemical insults and toxic agents never occurs in isolation. Any number of concurrent exposures can result from environmental factors. The complex network of integrated organ systems and metabolic pathways are altered by the presence of different agents, so it is possible …
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A systems toxicology framework for improving the identification of paracetamol overdose
Paracetamol (APAP) overdose is the leading cause of acute liver failure and a concerning global health issue. However, the current clinical treatment framework is heavily criticized for its sub-optimality. Within this thesis, a systems toxicology approach is taken in an attempt to provide further …
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Synthesis and evaluation of quinoline-5,8-diones and isoquinoline-5,8-diones as anticancer agents
This thesis outlines the design and synthesis of novel chemical routes towards a nascent class of functionalised quinoline-5,8-diones and isoquinoline-5,8-diones. The structured approach adopted is predicted to lead to advancements in the two frameworks, expanding the structural diversity of both …
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In vitro model of the fathead minnow hypothalamic-pituitary-gonadal axis for toxicological evaluation
Endocrine disrupting compounds (EDCs) are prevalent in the environment and affect both animals and humans. They cause serious concerns for individuals and populations because they impact reproduction by interfering with the hypothalamic-pituitary-gonadal axis (HPG axis). This changes fecundity at …
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Generation, Characterisation and Potential Health Effects of Tyre Wear Particles
… on tarmac, the rubber surface wears away, releasing micro and macroscopic tyre wear particles into our environment. Tyre wear particles are rapidly becoming a significant contributor to urban and suburban air pollution, driven by the move away from internal combustion engines and the …
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UNDERSTANDING CONDITIONAL MODES OF ACTIONS IN CHEMICAL-INDUCED TOXICITY USING RULE MODELS
It is estimated that 115 million animals are used in experimental testing each year. Hence, shifting efforts toward alternative methods for toxicity assessment is essential. However, slow regulatory acceptance of new approaches is governed by knowledge gaps in toxicity modes of action. In this …
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Phytochemistry and biological studies of constituents from Breonadia Salicina (VAHL) Hepper and J. R. I. Wood
Breonadia salicina (Vahl) Hepper and J.R.I. Wood is a tree used widely to treat numerous infectious diseases in South Africa and other African countries, and ethnopharmacological studies have shown a number of biological activities of the crude extracts. Furthermore, phytochemical studies have …