Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"in vitro toxicity"”.
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The development of functional in vitro toxicity tests
In vitro toxicity tests which detect evidence of the formation of reactive metabolites have previously relied upon cell death as a toxicity end point. Therefore these tests determine cytotoxicity in terms of quantitative changes in specified cell functions. In the studies involving the CaC0-2 cell …
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In vivo and in vitro toxicity of M-741 (3,15 di-(5,5-dimethyl-3-N(-(cyclopropylmethylinium)-(N-propylinium));-1-cyclohex-1-enyl);-7,11,18,21-tetraoxa-3,15-diazatrispiro (5.2.2.5.2.2); heneicosane)
… (3,15 di-[5,5-dimethyl-3-N[-(cyclopropylmethylinium)-(N-propylinium]-1-cyclohex-1-enyl]-7,11,18,21-tetraoxa-3,15-diazatrispiro [5.2.2.5.2.2] heneicosane produces hepatotoxicity in rats following intravenous administration. Hepatocellular pathology is characterized by parenchymal cell necrosis …
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Development and Evaluation of Organometallic Anticancer Drug Candidates
There is an urgent need to find novel anticancer therapeutics with different mechanisms of action than platinum-containing drugs, particularly for patients who relapse after having been initially treated with a platinum-containing chemotherapy regimen. This chemoresistance phenomena, along with the …
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Development and Evaluation of Organometallic Anticancer Drug Candidates
There is an urgent need to find novel anticancer therapeutics with different mechanisms of action than platinum-containing drugs, particularly for patients who relapse after having been initially treated with a platinum-containing chemotherapy regimen. This chemoresistance phenomena, along with the …
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Avaliação da atividade anti-Helicobacter pylori e citotóxica in vitro de extratos orgânicos obtidos das folhas de Encholirium spectabile e Syzygium cumini
… lymphoid tissue (MALT) lymphoma, constituting an important microorganism in medical microbiology. Its importance comes from the difficulty of treatment because the requirement of multiple drugs use, besides the increasing emergence of resistant and multiresistant strains to antibiotics used …
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Advancements in branched bottlebrush polymers for responsive, targeted imaging
… and stimuli responsive nanoparticles are promising platform materials for medical imaging and diagnostics. Specifically magnetic resonance imaging (MRI) and nearinfrared (NIR) fluorescent probes can be used in combination to visualize biodistribution and in vivo clearance rates. We reasoned that …
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The Development of a Novel Tumor -Specific MRI Contrast Agent Targeting the High Affinity Folate Receptor: In Vitro and in Vivo Specificity, Toxicity, and Biodistribution
… target-specific MRI contrast agents to aid in disease characterization remains highly essential. Here, we present a generation four polyamidoamine (PAMAM) dendrimer conjugated to folic acid that specifically targets the high affinity folate receptor (hFR) overexpressed on more than 80% of …
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A Transferrin conjugated nanoemulsion system for brain delivery of antiretroviral therapy
… is one of the critical complications of HIV infection that causes severe morbidity and even shortens survival. This complication is challenging to treat because most of the antiretroviral therapeutic (ART) agents cannot achieve the desired therapeutic levels in the central nervous system …
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Novel approaches and pharmacological considerations in melanoma treatment
Melanoma is the most aggressive skin cancer, traditionally known to be extremely resistant to common chemotherapeutics, and difficult to treat once metastasised. The prognosis of malignant melanoma is strongly dependent on early detection and disease stage. Recently a number of promising …
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Chemical composition and toxicity of emissions from burning five vegetation types of Western Australia under experimental combustion conditions
This study investigated the emission factors (EFs) for inorganic gases (CO2, CO, SO2, NO and NO2), carbonyls (formaldehyde, acetaldehyde, acetone, propionaldehyde, butyraldehyde and benzaldehyde), volatile organic compounds (VOCs) and particulate matter (PM2.5 and PM10) from laboratory-based fires …
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Development of Polymeric Nanocarriers for Dual Magnetic Resonance Imaging and Drug Delivery
Two types of (polymer-imaging agent-drug) complexes were prepared and characterized. These included block and graft copolymer complexes with magnetite nanoparticles and manganese ions. Magnetite block ionomer complexes (MBICs) were formed through binding of a portion of the anionic segment of …
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The Role of Small Peptides in Cancer Physiology and Chemotherapy
<p>The targeting of proven anticancer drugs specifically to cancer cells would provide a unique opportunity to restrict neoplasms without damaging the cancer patient. The present research utilizes the phenomenon of illicit transport, i.e. the coupling of normally impermeant metabolites to permeant …
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Developing Novel Nanoparticulated Imaging System using Luminescence Enhancement of Eu(III) and TB(III) by Single-Strand DNA Encapsulation
<p>Non-toxic biosensors are encountering an increase in attention for use in understanding the fate of cells and as a diagnostic tool. Development and incorporation of suitable fluorophores into biological molecules is the key for monitoring proteins <em>in vivo </em>research. This study …
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Predictive Modelling of the Primary and Secondary Pharmacology of Compounds in Drug Discovery
Understanding the primary and secondary pharmacology of drugs is imperative for delivering a drug molecule which has the necessary efficacy and safety profile in humans. The application of machine learning and data mining methods to drug discovery has the promise to accelerate the drug discovery …
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Determination of the in vitro antidiabetic potential of a polyherbal commercial tea
Type 2 diabetes mellitus (T2DM) is an increasing global health concern, currently affecting an estimated 382 million individuals. There is no cure for T2DM and the search for new and improved treatments is ongoing. Presently, various pharmacological regimens are available to treat T2DM, but with …
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Investigating xanthine oxidase toxicity models in cultured cerebellar granule neurons
In the last few decades, evidence has been accumulating for a role for xanthine oxidoreductase (XOR)-generated toxic reactive oxygen species (ROS) in a variety of pathological conditions that affect different organ systems. This enzyme in mammals exists in two inter-convertible forms: xanthine …
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CYTO-GENOTOXIC EFFECTS OF SOME PHARMACEUTICAL AND PERSONAL CARE PRODUCTS (PPCPS) ON THE FRESHWATER BIVALVE ZEBRA MUSSEL (DREISSENA POLYMORPHA)
… and personal care products (PPCPs) are an emerging class of environmental pollutants that are extensively and increasingly being used in human and veterinary medicine. Due to their continuous production, consumption and often abuse, many studies have shown worldwide measurable concentrations of …