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Showing 1 to 20 of 22 for “"in vitro stimulation"”.
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Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy
Human immunodeficiency virus (HIV) infected children are at greater risk of developing tuberculosis disease, and might benefit from vaccination with novel TB vaccines. However, little is known about the effect of HIV-infection on function and phenotype of T cell responses to mycobacterial antigens …
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Understanding the function of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis
The inducible costimulatory molecule (ICOS) is a relatively new member of the CD28 family of costimulatory molecules. For the first time, we have characterized the role of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis (EAMG), a model of human MG. Following acetylcholine …
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MAdCAM-1 expression and function in human liver
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is a tissue–specific protein that promotes α4β7+ lymphocyte recruitment on gut mucosal endothelium, playing an important role in the development of inflammatory bowel disease (IBD). Recent studies have reported its expression in liver diseases …
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Studies on Lymphokine Activity in the Amphibian Rana Temporaria
… Rana temporaria, is capable of elaborating a range of soluble mediators, analogous to mammalian lymphokines. In vitro stimulation of Rana temporaria leucocytes, with both antigens and mitogens, was employed. The supernatants from such stimulated cultures were applied to assay systems, in …
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Optimising Recording & Stimulation Performance of Neuronal Microelectrode Arrays through Macroporous Conducting Polymer Modification
Microelectrodes are commonly used to interface with electrically active cells, such as neurons (typically as an array of microelectrodes) allowing for their monitoring (recording) and manipulation (stimulation). Recent trends towards smaller electrodes for improved spatial resolution have revealed …
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Characterization of human IgA-inducing protein
… years there has been a great deal of progress in characterizing the role of dendritic cells (DCs) in the activation and modulation of B cells. DC-secreted chemokines can induce B cell trafficking to the lymph nodes. DC-produced survival factors such as BAFF and APRIL have been shown to be …
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Untersuchungen zur Produktion und Chaperoninteraktion von Yersinia YopE und SycE mittels Reporterfusionstechnologie
Yersinia enterocolitica produzieren Pathogenitätsfaktoren, die es ihnen ermöglichen, an die Zellen des Wirtes zu adhärieren, diese zu invadieren und protektive Immunantwort des Wirtes zu modifizieren. Dazu gehören die Yersinia outer proteins (YOP), die durch den Typ III Sekretionsweg über die …
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Gestörte Expression von CD70 und CD86 auf naiven CD27-B-Lymphozyten von Patienten mit Variablem Immundefektsyndrom (CVID)
… aller klassengewechselten Immunglobuline (IgG, IgA, IgE) und daraus resultierenden rekurrenten Infektionen der oberen Atemwege und des Gastrointestinaltraktes. Dazu passend besitzen die meisten CVID- Patienten in ihrem peripheren Blut stark erniedrigte Anteile an klassengewechselten …
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Molecular defects in B lymphocytes from patients with CVID- syndrome
… disease, the hallmark of which is hypogammaglobulinemia. A number of defects of T cell function and deficits in the memory B cell pool have been identified, but the underlying cause for this defect remains unknown. In vitro stimulation experiments with CVID peripheral blood B cells (CD19+) showed, …
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Vitamin A and glycoproteins of rat corneal epithelium
… has shown that the uptake of labeled precursors into a single specific glycopeptide in the rat intestinal mucosa was depressed significantly in vitamin A deficiency (De Luca et al ., 1970). A very similar pattern to the intestinal glycopeptide pattern was obtained from the rat corneal epithelium; …
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Role of plasma membrane ATPase4 in the pathophysiology of pulmonary arterial hypertension
… characterised by pulmonary vascular remodelling, inflammation, and excessive apoptosis of pulmonary arterial endothelial cells (PAECs). Elevated levels of pro- inflammatory cytokines such as TNF-α are a hallmark of PAH and are known to induce endothelial injury. Calcium dysregulation …
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In Vivo Identification of SLE1B: LY108 Mediates Autoantibody Production
In the NZM2410 model of murine lupus, Sle1b mediates anti-nuclear autoantibody (ANA) production. Our goal is to determine the causative gene in the Sle1b locus. Seven members of the SLAM/CD2 family are located within the Sle1b interval, and previous work has shown that structural and expression …
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Auswirkung der in-vitro Allergenstimulation auf die Zytokinexpression bei allergischen Erkrankungen : Untersuchung der Bildung von TH1- und TH2-Zytokinen und ihrer Beeinflussbarkeit durch den Histamin-Rezeptor-Antagonisten Desloratadin
Auswirkung der in-vitro Allergenstimulation auf die Zytokinexpression bei allergischen Erkrankungen <br>Untersuchung der Bildung von TH1- und TH2-Zytokinen und ihrer Beeinflussbarkeit durch den Histamin-Rezeptor-Antagonisten Desloratadin <br> <br>In der vorliegenden Arbeit wurde die allergische …
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Conducting Polymer Implant for On-demand Ocular Drug Delivery
Introduction: Implants have become an attractive treatment option for chronic posterior eye conditions. However, a patient’s disease state and any concurrent side-effects may require a dose adjustment which is not possible with currently marketed implants. Stimuli-responsive implants present an …
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Decoding Disease Drivers Through Single-Cell Omics and Scalable Phenotypic Screens
… and hyperimmunity—a lack of homeostasis. In many cases, a more comprehensive understanding of the molecular basis underlying disease progression and therapeutic failure is still required to devise new strategies for improving patient outcomes. Technological advancements in biomedical …
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Einfluss von Interleukin-18 auf das Th1/Th2-Zytokingleichgewicht mononukleärer Nabelschnurblutzellen in vitro
… 1989 beschrieben und lange Zeit als "IFN-Gamma inducing factor" bezeichnet, welcher die Ausbildung einer Th1-Immunantwort stimuliert. In den letzten Jahren konnte für IL-18 zudem die Induktion Th2-spezifischer Zytokine aufgezeigt werden. Bei Atopikern, welche durch das Überwiegen der Th2- …
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Dissecting immune interactions in health and disease with multiomics and spatial technologies
Cells are the basic building blocks of life, forming the enormous plethora of tissues and living organisms on Earth. They have a high diversity of phenotypes and functions in different environments. The high-throughput tools to profile different modalities from a single cell have grown …
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UNCOVERING IMMUNE EVASION MECHANISMS FOR THE PROGNOSIS AND THERAPY OF ENDOMETRIAL AND OVARIAN CANCERS
… are a heterogeneous group of solid tumors which include endometrial cancer (EC) and ovarian cancer (OC). EC is the most common gynecological neoplasm and the only gynecologic cancer with increasing incidence and mortality. It is generally diagnosed at an early stage and is well managed with …
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Immune Control of Hepatitis B Virus infection by innate lymphocytes
Hepatitis B virus (HBV) infects over 300 million people worldwide and despite the availability of a vaccine, it remains the second biggest carcinogen in the world and a serious global health problem. The majority of adult infections are resolved while 90% of neonates fail to clear infection. …
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Investigations into the immunology, physiology and epidemiology of pertussis
This volume contains an introduction to the topic of pertussis followed by twelve papers on pertussis arising from research conducted while I was a research fellow at St. George's Hospital Medical School from 1985 to 1988. Paper 1 provides a qualitative description of the serum antibody responses …
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