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Showing 1 to 20 of 242 for “"in vitro models"”.
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Advanced in Vitro Models for Studying Bone Physiology
<p>Bone is a highly calcified organic-inorganic composite tissue with complicated hierarchical structure. The presence of complex multi-cellular organization within opaque mineralized matrix makes it challenging to use conventional methods to study in vivo bone physiology even using model animals. …
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In vitro models for airway epithelial cell culture
… factors such as the cell substrate properties including its stiffness, shear stress, stretch, the air-liquid interface and the biochemical factors in the medium influence the biology of the cells. The aim of this work is to closely approximate conditions in an in vivo situation by engineering …
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In Vitro Models of Cellular Dedifferentiation for Regenerative Medicine
… the ability to self-renew and to differentiate into a variety of cell types. Stem cells can be found naturally in the body, can be derived from the inner cell mass of blastocysts, or can be made by dedifferentiation of adult cells. Regenerative medicine aims to utilize the potential of stem …
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Engineering in vitro models of non-alcoholic fatty liver disease
… scarcity of affordable, healthy food is contributing to rising obesity rates throughout the world. Consequentially, non-alcoholic fatty liver disease (NAFLD), which is highly correlated with obesity, rates are also increasing with greater than 30% of the US population currently diagnosed. NAFLD …
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Bioelectronic in vitro models for monitoring intestinal host-pathogen interactions
The human gastrointestinal tract is a highly complex, dynamic interface where host-microbe interactions not only underpin digestion and immunity but also disease pathogenesis. Studying this in vitro requires models that not only sufficiently recapitulate the physiological complexity of the barrier …
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Control of Inflammation Using Drug Delivery Strategies in in vitro Models
<p>Regulation of inflammation is a crucial component of the immune system in response to injury and infection. In otherwise healthy individuals, an initial acute inflammatory response will subside once the injury or infection is eradicated. However, in certain disease states including autoimmune …
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Insulin Resistance and Inflammation in Neurodegeneration: Lessons from in vitro Models
Type 2 diabetes (T2D) is a growing epidemic of the developed world and significantly increases the risk for neurodegenerative diseases such as Alzheimer’s disease (AD). Current evidence suggests that these two diseases are closely linked. Both share common etiologies such as insulin resistance (IR) …
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Investigating the modulation of oral drug absorption using in vitro models
Dipeptides can be absorbed into cells via the dipeptide transporter (which also transported tripeptides and dipeptide derivatives). The optimum conditions for measuring the inhibition of Gly-Pro uptake in Caco-2 cells were identified. A number of structure-activity relationships were identified. …
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Developing druggable in vitro models for investigating itch in atopic dermatitis
… that drives a desire to scratch. It can induce severe skin damage and critically affect psychological wellbeing (e.g., sleep-deprivation, body-image insecurity). To investigate the burden of itch, a survey was conducted with ~2500 women within the general German population, where more …
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Nutritional evaluation of α-cyclodextrin using canine, hamster, and in vitro models
The main objective of this research was to characterize the nutritional effects of α-cyclodextrin (ACD) using in vitro, canine, and hamster models. Study 1 evaluated the composition of ACD, validated select fat analysis techniques as related to ACD-fat complexes, and evaluated the gastrointestinal …
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Establishing in vitro models of neuroinflammation to investigate neuroimmune responses in neurocysticercosis
Neurocysticercosis (NCC), a parasitic infection of the central nervous system (CNS) caused by the larvae of the cestode Taenia solium, is the leading cause of adult-acquired epilepsy in the world. A surprising clinical manifestation of NCC is that viable larvae can exist in the brain for extended …
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In vitro models for injurious compression of bovine and human articular cartilage
Patients who have sustained a traumatic joint injury, such as a ligament rupture or cartilage fracture, are known to have an increased risk for the development of osteoarthritis (OA) in that joint. This has motivated the use of in vitro models of mechanical cartilage injury in order to identify …
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Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models
… cells (MSCs) have great potential to improve clinical outcomes for many inflammatory and degenerative diseases through delivery of exogenous MSCs via injection or cell-laden scaffolds and through mobilization and migration of endogenous MSCs to injury sites. MSC fate and function is determined …
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INVESTIGATIONS ON POTENTIAL OF UMBILICAL CORD LINING STEM CELLS FOR IN VITRO MODELS
Since their discovery, stem cells have been highly regarded for their potential in applications ranging from bench top studies, pharmaceutical applications to cell-based therapy. In our study, the potential of human umbilical cord lining stem cells (UCLSCs) for in vitro models is investigated in …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
The lymphatic system is a network consisting of lymphatic vessels and lymphoid organs such as lymph nodes (LNs), which drain excess interstitial fluid and eventually return it to the blood circulatory system via the thoracic duct and subclavian veins. It plays a key role in interstitial fluid …
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