Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"in vitro modelling"”.
-
In vitro modelling of human glioblastoma migration and angiogenesis
Glioblastoma (GBM) invasion and angiogenesis are critical for the tumour's fast growth and recurrence. A significant limitation in the development of innovative anti-invasive and anti-angiogenic treatments is the lack of personalised in vitro experimental models to accurately recreate the …
-
Clinical aspects and in vitro modelling of GBA1 variant-associated Parkinson's disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease, characterised by a typical movement disorder, accompanied by a number of non-motor manifestations including cognitive impairment, neuropsychiatric symptoms, autonomic features and sleep disturbance. The aetiology of PD is …
-
In-vitro Modelling of Stromal and Immune Cell Interactions Following Surgical Bone Marrow Stimulation
Osteoarthritis (OA) results in degeneration of cartilage and bone within a joint, leading to pain and loss-of-function. While effective treatments exist for end-stage OA, earlier disease stages lack treatment options. Micro-fracture and micro-drilling, often termed bone marrow stimulation …
-
In vitro modelling of cellular haemozoin and inhibition by β-haematin inhibitors and their derivatives
The discovery of new β-haematin inhibitors has become one focus for researches in response to the resistance of P. falciparum malaria parasites that emerged towards well-known antimalarials. While hundreds of new β-haematin inhibitors have been discovered using detergent mediated high-throughput …
-
BRAIN ORGANOIDS AS MODELLING CONDUITS OF HUMAN NEURODIVERSITY: ADVANCED COMPUTATIONAL APPROACHES TO SINGLE CELL TRANSCRIPTOMICS
… (CNS) morphology and physiology results from finely orchestrated developmental processes. The introduction of human brain organoids (BOs), allowed to reach an unprecedented experimental tractability of brain development trajectories, surpassing the limitations of their preceding 2D models and …
-
RESOLVING TUMOR HETEROGENEITY THROUGH HIGH RESOLUTION MULTI-MODAL TRANSCRIPTOMICS: INTEGRATIVE SINGLE-CELL ATLASES AND GENERATIVE SPATIAL MODELING
Understanding tumor heterogeneity is essential for improving diagnosis, treatment, and drug development in oncology. This thesis explores how cutting-edge transcriptomic technologies and new computational frameworks can be used to dissect, interpret, and model the cellular complexity of solid …
-
Defining Microbiome Stability in First-Degree Relatives of Inflammatory Bowel Disease Patients
… emergent area of research focussed on understanding the intricacies of the symbiotic relationship we have with the millions of microbes in and on our bodies. The gut microbiome has been well established as a key modulator of health and disease. Inflammatory bowel disease (IBD) is a chronic …
-
Defining metabolic zonation as a determinant of hepatocyte plasticity
Liver regeneration following injury occurs through several well-defined mechanisms, including the hypertrophy or hyperplasia (proliferation) of epithelial cells and the recruitment and differentiation of hepatic progenitor cells. In specific contexts, experimental evidence suggests that mature …
-
Developing an a-synuclein in vitro model for therapeutic testing for Parkinson's disease
Parkinson's disease (PD) is a slowly progressive neurodegenerative condition affecting various regions of the central nervous system, including the brainstem, basal ganglia, and cerebral cortex. Genetic links between α-synuclein and PD, coupled with the identification of aggregated α-synuclein in …
-
THE INTERGENERATIONAL IMPACT OF ENVIRONMENTAL EXPOSURES: MOLECULAR INSIGHTS FROM MODELLING PLURIPOTENCY TRANSITIONS THROUGH THE HUMAN GERMLINE
How environmental exposures shape inheritance across generations is a fundamental question in biology, with far-reaching implications for human health. Despite evidence of such inheritance in animal models, its mechanisms and relevance in humans remain elusive due to key challenges: (i) the …
-
Development and characterisation of a human in vitro model of the Neurovascular Unit using a biomimetic tissue engineered system
… unit (NVU) is a complex structure comprising endothelial cells, pericytes, astrocytes, neurons, and extracellular matrix (ECM) elements. It plays an essential role in regulating cerebral blood flow and maintaining the integrity of the blood-brain barrier (BBB). Over the years, several …