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Showing 1 to 20 of 202 for “"in vitro experiments"”.
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In Vitro Experiments on the Specificity of Viral Rna Replication
Made available in DSpace on 2014-12-11T00:00:12Z (GMT). No. of bitstreams: 1 7105170.pdf: 5614570 bytes, checksum: 5c746d2e25ba9a02fe30c4d5d6023bb8 (MD5) Previous issue date: 1970
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In-vitro experiments on neuronal cells and computer modeling over realistic head models in TMS
… technique that can be used as a non-invasive method for treating various neurological disorders. The major principle of TMS is the Faraday’s law stating that time varying magnetic field induces electric field in nearby conductors. More specifically, magnetic field generated by TMS …
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Oxidative Stress and Inflammation in the Heterogeneity of Metabolic Health
Metabolic health is determined by complex biological processes that extend beyond anthropometric indicators such as body mass index (BMI). Chronic low-grade inflammation and oxidative stress are key mechanisms linking metabolic dysfunction to cardiometabolic disease, but their interaction across …
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Agent-based modelling of cell-cell interactions for in vitro vascular formation and cancer cell growth
… parts, that can be identical or different, that interact with each other and environment, and exhibit emergent behaviour. Here, I consider the formation of vascular structures in the body as a complex system consisting of an emergent pattern in interacting endothelial cells. A cancer tumour is a …
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Green fluorescent protein as a mechanical sensor
Inquiry into intracellular and cytoskeletal mechanics requires an intracellular mechanical sensor to verify models of sub-cellular structure dynamics. To this end, the green fluorescent protein (GFP) is considered as a mechanical sensor candidate with many desirable characteristics. Implicit …
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Comparative evaluation of the effects of whole essential oils and their active constituent compounds on the biohydrogenation of polyunsaturated fatty acids and fermentation characteristics of rumen microbes in vitro
… fatty acids (PUFA) were evaluated in four in vitro experiments and one feeding trial . In all the in vitro experiments, rumen fluid was collected from Hartline x Texel cross cull ewes. A basal feedstock comprising of 70:30 grass hay and concentrate was formulated, milled (1mm …
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Examination of type I IFN mediated regulation of the post-transcriptional antiviral response
Interferons (IFNs) are pleiotropic cytokines that regulate both innate and adaptive immunity. Early post viral infection, there is induction and secretion of IFN-β which alerts nearby cells and primes leukocytes for an immune response. A rapid response is necessary for effective control of virus …
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The functional effects of barium and hypoxia on the in vitro respiratory activity
The hypoxic respiratory response in mammals consists of a transit increase in the respiratory frequency (augmentation phase) followed by a decrease in frequency (depression phase). To understand how the central respiratory system contributes to this response, the in vitro transverse brainstem slice …
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The Synthesis, Characterization, Spectroscopic and Biological Activity Studies of Pt(Ii) and Pd(Ii) Cyanoximates
Some of the platinum (Pt) and palladium (Pd) compounds are established anticancer inorganice pharmaceuticals. Substantial biological activity (growth regulation, antimicrobial, pesticide detoxifying) was also found during the last two decases of investigations of cyanoximes. An attempt has been …
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Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres
Magnetic particle imaging (MPI) is an emerging imaging modality that specifically detects superparamagnetic iron oxide nanoparticles (SPIOs). Our lab has shown that cell tracking with magnetic resonance imaging (MRI) has very high sensitivity, but low specificity and quantification of iron labeled …
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A Mathematical Model of the Iron Regulatory Network in Aspergilus Fumigatus
… an opportunistic fungal pathogen responsible for invasive aspergillosis in immunocompromised individuals. Current detection and treatment strategies for invasive aspergillosis, as well as other invasive fungal infections, are poor. Iron has been shown to be essential for Aspergillus fumigatus …
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Rock inhabiting and deteriorating fungi from carbonate monuments of Persepolis
… monuments made of rock is particularly relevant in countries like Iran being rich in such cultural heritage. By using LM, SEM, Thin sections, PAS staining, maceration, culturing and molecular techniques different biodeteriorative agents were identified on and in the stone materials of Persepolis …
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Translation and transcription are required for endogenous bursting after long term removal of neuromodulators
Motor pattern-generating networks depend on neuromodulatory inputs to regulate the network activity. The pyloric network of the Cancer borealis stomatogastric ganglion (STG), a rhythmic motor pattern-generating network, requires modulatory inputs to generate this activity. When neuromodulatory …
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Dynamics and precursor signs for phase transitions in neural systems
This thesis investigates neural state transitions associated with sleep, seizure and anaesthesia. The aim is to address the question: How does a brain traverse the critical threshold between distinct cortical states, both healthy and pathological? Specifically we are interested in sub-threshold …
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THE IDENTIFICATION OF NOVEL INORGANIC CARBON SENSITIVE ENZYMES
… the formation of the second messenger adenosine-3’, 5’-monophosphate from adenosine triphosphate, and is involved in a number of diverse signalling pathways in eukaryotes and prokaryotes. Adenylyl cyclases are diverse in their structure and biochemistry, and have been grouped into six …
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Dissecting the Spatiotemporal Regulation of Yeast Kinetochore Interactions
Kinetochores are conserved protein complexes that bind the centromeres in replicated chromosomes to the mitotic spindle and then direct their segregation. To better comprehend Saccharomyces cerevisiae kinetochore function, we investigated the phospho-regulated dynamic interaction between the …
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Exploring the Regulation of Mitotic PP2A-Rts1 Activity in Saccharomyces cerevisiae
Protein phosphorylation is an essential post-translational modification used in cells for regulating multiple biological processes in all organisms. Particularly, mitotic onset is regulated in all eukaryotes by an increase in cyclin-dependent kinase 1 (Cdk1) activity caused by the dephosphorylation …
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DEVELOPMENT OF MOLECULAR PROBES ACTING ON aSYN/TUBULIN AND TAU/TUBULIN INTERACTION
Microtubules (MTs) are ubiquitous structures playing many roles in all eukaryotic cell types from fungi to mammals mainly consisting of conserved α/β tubulin heterodimers. Neurons are an impressive example of cells in which the contribution of MTs is fundamental to achieve their sophisticated cell …
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Novel Fluorescent Sensors for Dynamic Intracellular Signalling
Protein kinase C (PKC), comprised of ten isozymes, is an abundant regulator of cellular function. PKC activity in living cells is commonly assayed in in vitro experiments with cell lysate. Monitoring PKC activity in single living cells is not possible with such experiments. This thesis presents a …
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Bluttraumatisierung bei der Passage zeitkonstanter und zeitvarianter Scherfelder
Until today the employment of artificial systems in human circulation is limited by their reduced blood compatibility. This is mainly dependend on flow conditions and the contact to artificial surfaces. In blood pumps or artificial heart valves high fluid mechanical stresses are dominating. This …
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