Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"in vitro experimentation"”.
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Magnetostatic Modeling for Microfluidic Device Design
<p>Magnetostatic Modeling for Microfluidic Device Design</p> <p>Kirsten Marie Jackson</p> <p>For several years, biologists have used superparamagnetic beads to facilitate biological separations. More recently, researchers have adopted this approach in microfluidic devices [1-3]. This recent …
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DNA polymerase interactions and their role In translesion synthesis substitutions.
… mechanism that allows DNA replication to continue after a high fidelity (HiFi) polymerase stalls at a lesion. Upon stalling, the HiFi polymerase must be substituted with a TLS polymerase. The reverse substitution must occur promptly after lesion bypass to minimize error-prone synthesis by TLS …
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Interactions and epidemiology of nematode worm control in livestock
The livestock industry relies heavily upon anthelmintics for the treatment of parasitic nematode diseases. This has resulted in widespread resistance to multiple anthelmintic classes across several parasitic genera. In response to this spread in resistance and subsequent decrease in efficacy there …
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Investigating the impact of e-cigarettes on lung cells: a combined in vitro and computational study
The increasing use of electronic cigarettes (ECs), particularly among youth, has raised concerns about their impact on respiratory health. This thesis investigates the effects of EC aerosol exposure on the alveolar epithelium using a combination of in silico modelling and in vitro experimentation. …
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Growth Differentiation Factor 5 is a Paracrine Regulator of Sarcopenic Obesity
… loss more than sarcopenia and obesity alone. Individuals with SO suffer from the comorbidity of excess body fat and concurrent muscle mass loss due to aging. Growth differentiation factors (Gdfs) have never been recognized as playing a role in skeletal muscle maintenance in those with SO. …
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A Virtual Model of the Human Cervical Spine for Physics-based Simulation and Applications
<p>Utilizing recent advances in computer technology, Our Biomechanics Laboratory have made an effort to integrate computer animation and engineering analysis software into biomedical research, specifically towards simulation and animation of in vitro experimentation of the human cervical spine in …
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Technologies of living substance : tissue culture and cellular life in twentieth century biomedicine
… of tissue culture, that is, techniques for growing living cells and tissues outside of the bodies of complex organisms. The development of these techniques represents an important epistemological shift in biology from in vivo to in vitro experimentation. This was not just a shift from use of a …
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A MECHANISM FOR CORTICAL BONE STEM CELL-DERIVED EXOSOMES’ THERAPEUTIC EFFECT ON POST-MYOCARDIAL INFARCTION REPERFUSION INJURY AND CARDIAC REMODELING
Rationale: Heart failure is the one of the leading causes of death in the United States. Myocardial infarction (MI) is followed by cardiac remodeling involving extensive fibrosis and which can ultimately progress into heart failure. Previous studies have shown both that both post-MI and …
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Physical and biological characterisation of clinically relevant combined MRI-radiation exposures with conventional and nanoparticle contrast agents
Background:<br/>MR-Linacs provide a unique opportunity for MRI contrast agents to be investigated, not only for the ability to enhance contrast, but for their potential radiosensitising properties to improve radiotherapy treatments. Metal-based nanoparticle contrast agents have a preferential …
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A Mechanical and Histological Study of Functionally Graded Hydroxyapatite Implant Coatings
<p>Ever since Dr. Brånemark discovered that titanium was biocompatible with bone, extensive research has been done to improve the osseointegration of dental implants. As advances in medicine continue, the average life span of the population is ever increasing. Today, people of all ages are …
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Biosynthetic and bioinformatic investigation of RiPPs with radical SAM-installed crosslinks
… modified peptides (RiPPs) are an expanding class of natural products containing new chemical modalities and bioactive molecules. Although with diverse biological functions, significant research has been focused on investigating RiPPs with antibacterial activity due to the emerging …