Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"in vitro disease model"”.
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Development of Novel Therapies for Marfan Syndrome using a Human iPSC-disease model
… a connective tissue disorder caused by mutations in fibrillin-1, a matrix component encoded by the gene FBN1, with pleiotropic manifestations including severe cardiovascular complications, such as aortic aneurysms and dissection. Current treatments focus on surgically removing the aneurysm or on …
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Microfabrication Approaches for Understanding the Role of Vascular Mechanics in Progressive Diseases
Vascular disease is a common cause of death that typically results from long-term alteration of vessel structure and function. The underlying mechanisms that lead to pathologic changes in the vasculature are largely unclear, especially in progressive diseases of the cerebral vessels. With the …
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Metabolic control of neural stem cell function in a patient-derived model of multiple sclerosis
Multiple sclerosis (MS), the most prevalent inflammatory autoimmune disorder affecting the central nervous system (CNS), results in the deterioration of myelin sheaths and neuronal injury. For reasons that remain unclear, the majority of patients eventually enter a disease stage termed progressive …
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Treatment-resistant ophthalmoplegia in Myasthenia gravis: extraocular muscle pathology, the role of TGFβ1 and the derivation of induced pluripotency towards 'disease-in-a-dish' modeling
Myasthenia gravis (MG) is an autoimmune disease in which pathogenic antibodies target specific neuromuscular junction proteins, most frequently acetylcholine receptors (AChR). Among those without detectable AChR-antibodies, a subgroup of patients has antibodies directed against muscle-specific …