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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"in vitro characterization"”.
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In Vitro Characterization of Proglucagon Cleavage by PCI
… the sequential action of propeptide converting enzymes on less active precursors called propeptides. Propeptide converting enzymes recognize and cleave their respective propeptide substrates on the carboxy-terminal side of specific cleavage sites identified most commonly by dibasic residues …
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Quantitative In Vitro Characterization of Membrane Permeability for Electroporated Mammalian Cells
… by the response of biological membranes to high- intensity pulsed electric fields. These fields rearrange the membrane structure to enhance the membrane's diffusive permeability, or the degree to which a membrane allows molecules to diffuse through it, is impacted by the structure, composition, …
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In vitro characterization and in vivo assessment of equine tendon-derived progenitor cells
Tendinitis is a common cause of breakdown injury in equine athletes and accounts for 30% to 50% of all racing injuries. The last decade has seen significant development in mesenchymal stem cell (MSC)-based therapies in tendon repair. The focus on tendon-derived progenitor cells (TDPCs) for tendon …
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In vitro characterization of the antiviral activity of Secomet V against vaccinia virus infections
… the reference name for a plant extract produced in a bioreactor from primary plant stem cells, whose antiviral activity has been widely reported in folklore medicine. It exerted its anti-vaccinia virus activity by neutralizing cell-free virus rather than interfering with the downstream events …
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An In Vitro Characterization of the Raphe Nucleus and the Effects of SSRIs on Synaptic Neurotransmission
Antidepressants are traditionally used in the treatment of depression. While these drugs rapidly inhibit the reuptake of neurotransmitters in the synaptic terminal by blocking the serotonin and norepinephrine transporters, clinical efficacy can take several weeks. This phenomenon implies that …
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Plant regeneration in vitro, characterization and control of vitrification, and somaclonal variation in onion (Allium cepa L.)
… data tranferred 2014-07-01T11:32:03-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission
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Gene Therapy for Osteosarcoma : "In Vitro" Characterization of Five Tumor Cell Lines and Development of Treatment Models "In Vivo"
Four human osteosarcoma cell lines (MNNG, TE85, MG63, and G292) and a human-derived osteosarcoma metastatic to murine lung (MLM) were transduced "in vitro" using retroviral vectors containing the Herpes simplex thymidine kinase (HS-tk), human interleukin 2 (IL2). and B-galactosidase (BAG) genes. …
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In-vitro characterization of boronized titanium alloy by means of corrosion and electrochemical impedance spectroscopy methods in simulated body fluids
Titanium and titanium alloys are becoming the backbone of medical implants and prosthetics. Titanium alloys are used because of its high biocompatibility and similarity to bone. However, titanium and titanium alloys have a low wear resistance. Titanium and titanium alloys are susceptible to …
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In vitro characterization of aromatase, estrone sulfotransferase and estrone sulfatase activities in the porcine placenta and endometrium at 30, 60 and 90 days of gestation
The purpose of this investigation was to characterize the activities of three enzymes, aromatase, estrone (E1) sulfotransferase and E] sulfatase, in the porcine placenta and endometrium on d 30, 60 and 90 of gestation. These enzymes play key roles in determining in utero concentrations of …
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Investigating the transcriptional regulation by OxyR in Porphyromonas gingivalis.
Periodontal diseases are bacterially induced, inflammatory diseases which are responsible for loss of alveolar bone and connective tissue supporting the teeth which results in loss of teeth. Gram negative anaerobic bacteria are highly associated with these diseases. One of them is Porphyromonas …
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A Developed and Characterized Orthotopic Rat Glioblastoma Multiforme Model
… gaps needed to advance the goal of performing pre-clinical trials using an orthotopic rat glioblastoma model to evaluate the efficacy of high-frequency electroporation (H-FIRE) and QUAD-CTX tumor receptor-targeted cytotoxic conjugate therapies, individually and in combination, in …
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The development of a reverse genetics system for Machupo virus
… lethal viral pathogen with no approved vaccine or therapeutic to limit infection or outbreaks. Following implementation of rodent population controls after the initial outbreak, no cases of BHF were reported from 1976 to 1993. Reports in the last five years from the endemic region have …
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Emergency delivery of Vasopressin from an implantable MEMS rapid drug delivery device
… was designed, fabricated and validated for the in vivo rapid delivery of vasopressin in a rabbit model. In vitro characterization of device performance found the device capable of reliably and reproducibly delivering 85% of its loaded drug solution. A comparison of intraperitoneal and …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
Background: Traumatic injuries to the brain and spinal cord, including spinal cord injury (SCI), represent devastating conditions that lead to permanent loss of function, mainly due to the poor intrinsic regenerative capacity of the central nervous system (CNS). At the lesion site, the hostile …
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Functional and physiological discovery in the mannonate dehydratase subgroup of the enolase superfamily
In the current post-genomic world, the exponential amassing of protein sequences is overwhelming the scientific community’s ability to experimentally assign each protein’s function. The use of automated, homology-based annotations has allowed a reprieve from this efflux of data, but has led to …
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The introduction of incompatibility between Junin virus Z protein and other viral proteins results in impaired replication and attenuation
… Mammarenavirus with the family Arenaviridae contains many species that are pathogenic in human hosts. Among these, Junin virus (JUNV) is a New World mammarenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). AHF resulted in 15-20% case fatality during epidemics until the …
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Reengineering and Discovery of Nonribosomal Peptide Synthetases
… are an important class of natural products including the life-saving antibiotics penicillin and vancomycin and the deadly microcystins and cereulide. This important category of natural products is thus a focus of many research labs around the world, including the Kelleher lab. These often …
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Development of a Toolkit to Investigate Endocardial Endothelial Cellular Response in Left Ventricular Outflow Tract Pathologies
… membrane below the aortic valve. The underlying cellular mechanisms of this disease are currently unknown. I have created a toolkit to investigate the contributing factors of DSS membrane formation by isolating and characterizing endocardial endothelial cells (EECs) that line the left …
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HARNESSING NATURE’S MACHINERY: CHARACTERIZATION OF BACTERIAL BIOSYNTHETIC ENZYMES FOR CHALLENGES IN ORGANIC SYNTHESIS
… on Earth as early at 4.1 billion years ago. Since then, these microorganisms have evolved to compete and communicate using secondary metabolites, or natural products. This billion-year molecular “arms race” has enabled bacteria to biosynthesize complex molecules that are challenging for humans …
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