Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"in vitro assessment"”.
-
In Vitro Assessment of Bone and Cartilage Stimulating Peptides
Spinal fusion is an effective and one of the most commonly used surgeries to treat intervertebral disc degeneration (IDD) related low back pain. However, non-fusion still occurs in about 10-15% of the clinical cases. The global objective of this project is to develop a synthetic bone graft for the …
-
In-vitro assessment of modified resin adhesive-tooth interfaces
… research aimed to characterize the interfacial characteristics of modified dental resin-based adhesive systems bonded to sound and carious dental tissue. The modification included the incorporation of matrix metalloproteinase (MMP) inhibitors within the primers of these …
-
An In Vitro Assessment of The Potential for Engineered Nanoparticles to Modulate Innate Immunity
<p>The same properties that make engineered nanoparticles (ENPs) appealing for use in novel pharmaceuticals, biomedical and product enhancement applications (small size, large surface area and increased solubility) may also influence their ability to modulate immune defense and inflammatory …
-
In vitro assessment of fertilization and embryo development with Bovine spermatozoa after scrotal insulation
Fertilization and cleavage of bovine embryos depend not only on maternal involvement, but also on the paternal contributions that involve more than just providing the haploid male genome. Therefore, the overall objective of this project was to determine the impact of morphologically abnormal …
-
Development, evaluation, and In-vitro assessment of artificial intelligence antidiabetic predictive models from α-glucosidase inhibitors
Background: The global rise in the prevalence of diabetes mellitus (DM) poses a significant health challenge, necessitating effective therapeutic interventions. Type 2 DM (T2DM) remains the most prevalent form of diabetes, accounting for over 90% of cases. Intestinal α-glucosidase enzymes, located …
-
An in vitro assessment of the effects of feed-grade trace minerals on commercial phytase activity
Exogenous phytases have the capacity to increase the nutritional value of animal feeds through the hydrolysis of phytate-bound phosphorus. Inorganic trace minerals (ITM) routinely added to feed can negatively impact phytase activity. Recent research has shown that replacement of ITMs with organic …
-
NUTRITIONAL AND BIOACTIVE COMPOUNDS FROM AGRI-FOOD PRODUCTS AND BY-PRODUCTS: IN VITRO ASSESSMENT OF THEIR POTENTIAL HEALTH EFFECTS
The growing need to reduce the environmental footprint of human activities and to ensure sustainable food production has accelerated the transition toward more resource-efficient and nutritionally balanced food systems. At the same time, increasing consumer interest in healthpromoting and naturally …
-
Nanotexturisation of gold surfaces and its application to neural implants
… a new methodology for the improvement of the interface properties of gold electrodes for neural implants. The goal was to increase the surface area without a change in geometrical footprint of the electrode with nano-fabrication tools. A process has been created that uses Nanosphere …
-
Investigation to Identify the Influence of Mannitol as a Carrier on the Ex-Vivo Dose Emission and the In-Vitro Aerodynamic Dose Emission Characteristics of Dry Powder Inhalers of Budesonide
… marketed Easyhaler® 200 g formulation. Ex vivo assessment of deposition using the Easyhaler® multi-dose high resistance inhaler with reservoir was compared with the RS01® single dose capsule low resistance inhaler at two different inhalation rates. Aerodynamic characteristics, flow and surface …
-
Lactobacillus paracasei: an evaluation of the flavour diversification potential of the species through genomics, metabolomics and applications
Strains of Lactobacillus paracasei are commonly isolated from numerous and diverse niches, such as dairy products, plant materials and reproductive and gastrointestinal tracts of humans and animals. In cheese, strains of L. paracasei belong predominantly to the non-starter microbiota, which is …
-
CARATTERIZZAZIONE IN VITRO DELLA RISPOSTA A STIMOLI INFETTIVI DELLE CELLULE EPITELIALI MAMMARIE BOVINE (BME-UV)
In vitro assessment of bovine mammary epithelial cells response to infectious stimuli Non-specific (innate) immune response plays a major role in defending the udder from bacterial invasion. Moreover, recent investigations suggest that mammary gland epithelial cells could have a large and important …
-
The effect of precipitation techniques on bioadhesive microparticle characteristics
… precipitation technique was developed for preparing bioadhesive HPMC microparticles for nasal delivery. Aqueous gels of lactose:HPMC (1:1) were used as a model formulation, added to a precipitating solvent, and the effect of processing parameters such as stirring speed (1000-2000 rpm), needle …
-
MODERNIZATION OF THE MOCK CIRCULATORY LOOP: ADVANCED PHYSICAL MODELING, HIGH PERFORMANCE HARDWARE, AND INCORPORATION OF ANATOMICAL MODELS
… circulatory loop plays a pivotal role as the in vitro assessment tool for left heart medical devices. The standard design employed by many research groups dates to the early 1970's, and lacks the acuity needed for the advanced device designs currently being explored. The necessity to update …
-
Does an objective laboratory measurement of platelet quality correlate with clinical efficacy?
… quality and deterioration of function during ageing is poorly understood and difficult to measure. No single test is currently suitable to assess concentrate quality for product development purposes or to confirm suitability of individual concentrates for clinical use. Many of the studies …
-
Age-Related Effects on the Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways in Breast Cancer and the Characterization of Novel MEK5 Inhibitors
Age remains the most common demographic risk factor in breast cancer. The underlying cellular signaling mechanisms responsible for the age-associated rise in disease incidence have not yet been determined. Studies presented herein aim to elucidate age-related changes in the extracellular …
-
Development of Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spns2 for the Treatment of Multiple Sclerosis
Sphingosine-1-phosphate (S1P) is an amino-alcohol signaling molecule produced from the intracellular phosphorylation of the lipid sphingosine. Despite possessing several identified intracellular targets, the predominant signaling functionality of S1P is derived from its activation of membrane-bound …
-
AN INQUIRY OF THE SR/CR MOUSE PHENOTYPE AND ADVANCES REGARDING THE SEARCH FOR AN ANALOGOUS HUMAN TRAIT
In 1999, researchers within our laboratory observed the unique occurrence of cancer resistance in a single BALB/c mouse. Subsequent breeding studies found that this trait, known as Spontaneous Regression/Complete Resistance (SR/CR) is heritable among 30 to 40 % of offspring in an autosomal manner, …
-
In vitro inflammatory response evaluation of pre-degraded bioresorbable polymers
… and their related copolymers have become increasingly popular in the biomedical field, and especially for the preparation of bone substitute constructs. However, there are reports of a delayed inflammatory reaction occurring months or years after implantation. Despite clinical studies …
-
Use of Echogenic Immunoliposomes For Delivery of Both Drug and Stem Cells For Inhibition of Atheroma Progression
… for Delivery of both Drug and Stem Cells for Inhibition of Atheroma Progression </strong></p> <p>By Ali K. Naji B.S. Advisor: Dr. Melvin E. Klegerman PhD</p> <p><strong>Background</strong> and significance: Echogenic liposomes can be used as drug and cell delivery vehicles that reduce atheroma …
-
THE EFFECTS OF MYOCARDIAL INFARCTION ON NEUROINFLAMMATION: FOCUS ON THE ROLE OF EXTRACELLULAR VESICLES
… diseases (CVDs) are considered the leading cause of premature death globally, with an estimated 17 million deaths yearly, according to the World Health Organization (WHO). CVDs include a collection of diseases, most importantly cardiac ischemia. Complications following cardiac ischemia …
Page 1 of 2