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Showing 1 to 20 of 185 for “"in vitro assays"”.
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Entwicklung eines organotypischen In-vitro-Assays zur Analyse der Gliominvasion
Die Gliominvasion in weißer Substanz des Gehirns stellt eines der unbewältigten klinischen Probleme dar. In dieser Arbeit wird die Entwicklung eines in vitro Assays beschrieben, der es ermöglicht, die Gliominvasion an einem Hirnschnitt zu verfolgen und zu quantifizieren.
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A Comparison of Two 'In Vitro' Assays to Assess Radiosensitivity in Patients Receiving Radiotherapy
… the occurrence of normal tissue damage as a limiting factor in curative radiotherapy and the need for predictive radiosensitivity testing. Patients who display unusual sensitivity to radiation may also exhibit a poor DNA repair capacity. Consequently, in vitro assays which assess radiation-induced …
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Vitamin E und der vesikuläre Transport : Untersuchungen zu den genregulatorischen Funktionen von Vitamin E mittels Microarray- und real time PCR-Analysen in der Maus und funktionellen in vitro Assays in RBL-2H3 Zellen
Vitamin E wird immer noch als das wichtigste lipophile Antioxidanz in biologischen Membranen betrachtet. In den letzten Jahren hat sich jedoch der Schwerpunkt der Vitamin E-Forschung hin zu den nicht-antioxidativen Funktionen verlagert. Besonderes Interesse gilt dabei dem α-Tocopherol, der …
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Investigation of inhibitors of polysialyltransferase as novel therapeutics for neuroblastoma. Development of in vitro assays to assess the functionality and selectivity of novel small-molecule inhibitors of polysialyltransferases for use in neuroblastoma therapy
… acidis an onco-developmental antigen, expressed in tumours principally of neuroendocrine origin, notably neuroblastoma,strongly correlating with invasion and metastasis. Polysialylation is regulated by two polysialyltransferase enzymes, PST(ST8SiaIV)and STX(ST8SiaII),withSTX dominant in cancer. …
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Evaluation of methodology for determination of availability of amino acids and energy in feedstuffs for poultry
In vitro and in vivo methods were evaluated for determining protein quality and availability of amino acids (AA) and energy in various feedstuffs or feed ingredients for poultry. In vitro assays included pepsin digestibility and lanthionine analysis. In vivo methods involved protein quality chick …
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Bacterial Challenge in Lumbricus Terrestris: A Terrestrial Invertebrate Immunotoxicity Model.
A bacterial challenge assay was developed utilizing the earthworm, Lumbricus terrestris, in order to assess potential immunotoxic effects from exposure to specific polychlorinated biphenyl congeners. Earthworms were inoculated with Aeromonous hydrophila, establishing a 10-day LD50. In vitro assays …
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Structural and Functional Characterization of B. Anthracis Udp-Glcnac 2-Epimerase and Salmonella Secreted Effector I
… biology has been an exceptionally powerful tool in the study of bacterial pathogenesis, not only in elucidating the molecular basis of disease as the first step towards the design of therapeutics but also in many cases leading to insights into hostpathogen biology that would not have been …
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Nanotoxicity of oxide-derived engineered nanomaterials: impact on cell viability and function, with conventional assays and evaluation of novel eicosanoid profiling
… highlight a direct association between the decline in respiratory health of the human population and increased environmental ultrafine particulate (UFP) exposure. This evidence, coupled with research identifying shared characteristics and toxicity between UFP and engineered nanomaterial (ENM), …
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Modelling RANBP2-ALK-rearranged Epithelioid Inflammatory Myofibroblastic Sarcoma
Epithelioid inflammatory myofibroblastic sarcoma (eIMS) is an aggressive variant of inflammatory myofibroblastic tumour characterised by ALK staining that is perinuclear or cytoplasmic with perinuclear accentuation, CD30 expression and early relapse despite crizotinib treatment [1, 2]. This study …
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New technologies and methodologies for the study of human mammary epithelial differentiation and development
The mammary gland is unique among human tissues in that the bulk of its development occurs postnatally, under hormonal control. The gland consists of an epithelium that expands dramatically during puberty and pregnancy, and is the site of breast cancer initiation. Important connections between …
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Regulation of Cyclin G2 Degradation in Human Ovarian Cancer Cells
… governed by temporal expression of canonical cyclin molecules, which then bind to and activate CDKs. Cyclin G2, an unconventional cyclin, negatively regulates cell cycle and its levels are lowered in various types of cancer. Our lab has previously reported that cyclin G2 is an unstable protein, …
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Zellbiologie der Knochenresorption
… aseptischen Prothesenlockerung ergaben Hinweise auf eine direkte Beteiligung von aktivierten Fibroblasten. Bisher war ausschließlich Osteoklasten die Fähigkeit zur Knochenresorption zugeschrieben worden. In der vorliegenden Arbeit wurden Fibroblasten aus der synovialen Membran von …
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The laboratory assessment of thyroid function with special reference to the importance of thyroid abnormality in psychiatric disease
The aims of this study were to investigate the incidence and clinical importance of thyroid abnormalities in an acute psychiatric population and to use such information in the development of a laboratory diagnostic policy for the investigation of such groups. This involved the use of established in …
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Cellular and in-vitro models to assess antioxidant activities of seaweed extracts and the potential use of the extracts as ingredients
Seaweeds contain a range of antioxidant compounds such as polyphenols, carotenoids, sulphated polysaccharides and vitamins and have the potential to be used as ingredients in neutraceuticals. The antioxidant activity of crude 60% methanol extracts prepared from five Irish seaweeds, Ascophyllum …
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Engineered Anti-CD40 Agonist Antibody for Cancer Vaccine Delivery
Cancer vaccines targeting patient-derived neoantigens offer great promise for personalized cancer therapy but face challenges in achieving targeted delivery to antigen-presenting cells (APCs) to elicit robust and durable cancer-specific immune responses. We synthesized an anti-mouse CD40 …
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Genetic and biochemical analysis of a conserved DEAD-box helicase motif
DEAD-box proteins are non-processive helicases that use ATP to power unwinding of short RNA duplexes in essential steps of RNA metabolism. Despite acting on a diverse range of RNA substrates, DEAD-box proteins share a helicase core defined by 13 highly conserved amino acid motifs. Here we use S. …
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Recursive Behavior Recording: Complex Motor Stereotypies and Anatomical Behavior Descriptions
… descriptive taxonomy improves motion capture in complex motor stereotypies (CMS) by indexing precise time data without degradation in the complexity of whole body movement in CMS. The absence of etiological explanation of complex motor stereotypies warrants the aggregation of a core CMS …
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Biochemical characterization of the E. coli Very Short Patch Repair pathway and its coordination with methyltransferase repair of 0⁶-methylguanine
… Dcm-mediated methylation and subsequent deamination of the underlined cytosine residue in the palindromic sequence 5'-CCWGG-3' (W is an adenine or thymine). Vsr initiates VSPR by producing a single stranded nick on the 5' side of the mismatched T. The MutS and MutL mismatch recognition …
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Zebrafish as a Model for Studying Estrogen Signaling and Estrogenic Endocrine Disruption
Estrogen signaling, mediated by estrogen receptors (ERs) and G-protein-coupled estrogen receptor (GPER), plays important roles in humans and wildlife. Perturbing estrogen signaling may lead to deleterious health problems such as infertility, developmental defects, metabolic disorders, and certain …
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