Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"in vitro analysis"”.
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In silico and in vitro analysis of calcific and rheumatic aortic stenosis
… heart disease characterised by the narrowing of the aortic valve opening that restricts blood flow from the left ventricle to the aorta. AS is caused by different pathologies that each result in a specific valve opening morphology. The most common types of AS are degenerative or calcific …
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Molecular Mechanisms of Melatonin Action on the Rat Suprachiasmatic Nucleus: An in Vitro Analysis
"Daily rhythms in behavior, physiology, and metabolism are synchronized to the solar cycle by the suprachiasmatic nucleus (SCN) of the mammalian brain. Cells of the SCN undergo a near 24-hour pattern of cellular events that convey time-of-day information to target organs. The endogenous nature of …
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In vitro analysis of volatile organic compounds in search of potential biomarkers of lung cancer
Lung cancer is a leading cause of death from cancer worldwide. An early diagnosis andappropriate treatment are crucial in reducing mortality among people suffering from thedisease. Therefore, one of the main focuses of lung cancer studies is on advances in itsearly detection. One of the most …
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In Vitro Analysis of Short Chain Fatty Acids and Human Fecal Microbiota Stimulated by Pectin Sources
<p>As interest increases for colonic health, various studies have been conducted to investigate functional ingredients for host health and prevention of chronic disease in humans such as colon cancer and Type 2 diabetes. In particular dietary fiber has been reported to have beneficial effects on …
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In-vitro analysis of microfilariae phenotypic responses induced by small molecules and dsRNA targeting receptor pathways
… companion animals. Current methods of control include a range of anthelmintics. However, with resistance on the rise, drug target discovery and development are urgently needed. This study explores phenotypic responses in microfilariae to small molecules as well as dsRNA molecules targeting …
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A comparative in vitro analysis of the Mobin-Uddin, Kimray Greenfield and Nitinol blood clot filters
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1982.
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In vitro analysis of boron-10 uptake and neutron beam design for boron neutron capture synovectomy
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1996.
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The Role of the Extracellular Matrix components of Salmonella enterica serovar Typhimurium Biofilms in Biofilm Formation and Architecture via in vitro analysis
… are aggregates of bacterial cells enclosed within a self-generated extracellular matrix, forming a three-dimensional structure that allows the bacteria cells to firmly attach to both living and non-living surfaces. The extracellular matrix of Salmonella enterica serovar Typhimurium (STm) …
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The role of linker histone variant in double strand break repair
Eukaryotic DNA is packaged into chromatin, providing a physical and structural barrier for regulatory and effector proteins to access the DNA. It has been shown that linker histone variants inhibit the double strand break (DSB) repair pathway known as non-homologous end joining (NHEJ). NHEJ, in …
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Characterization of Class D VPS Proteins
… The components of the VPS (vacuolar protein sorting) system are responsible for proper delivery of vacuolar biosythetic enzymes. Efforts to dissect the genetics of this system have revealed several classes of mutants, each defective in one transport step in the VPS pathway. The Class D VPS …
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The construction and characterization of recombinant sindbis virus vectors as a platform for anthrax vaccine development
The intentional release of anthrax spores in the U. S. mail system and the subsequent fatalities have renewed interest in developing therapeutics to protect against B. anthracis. Anthrax Vaccine Adsorbed (AVA) is the only licensed vaccine preparation currently used however, immunogenicity is …
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Nanomaterials and Block Copolymers for Overcoming Multidrug Resistance in Cancer
The development of multidrug resistance in cancer is one of the leading causes for decreased chemotherapy efficacy and is particularly threatening to aggressive cancers such as that of the pancreas. In cancers where chemotherapy is amongst the few treatment options, it is crucial to develop …
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Transmission Dynamics Of Mycobacterium Avium Subspecies Paratuberculosis In Closed Dairy Herds In The Us
In this work we present work focused on within farm dynamics of Mycobacterium avium subsp paratuberculosis (MAP) infection on commercial US dairies. We focused on using deterministic mathematical models informed by molecular epidemiology and analysis of longitudinal data to evaluate current …
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Analysis of a membrane type blood oxygenator and a ventricle type blood pump
This study presented the development and in vitro analysis of the Arp Hembrane Type Blood Oxygenator and a ventricle type blood pump. The system is designed for newborns suffering from Respiratory Distress Syndrome (R.D.S.), especially the 15% who are unable to be helped by the Arp Infant …
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The Effects of a Blend of Essential Oils on Rumen Efficiency of Lactating Dairy Cows
… oils (EO) on rumen microbial efficiency and kinetics, and consequently, effects on production parameters of dairy cows fed a low-starch diet and in vitro analysis of varying doses of SS on ruminal fermentation at different stages of lactation. The study consisted of two experiments, the in …
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Structure and function of glutamate transporters
The work presented in the following chapters primarily involves determining specific structural and functional features involved with glutamate transport by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal …
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Structure and function of glutamate transporters
The work presented in the following chapters primarily involves determining specific structural and functional features involved with glutamate transport by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal …
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The role of Surfacant Protein D in the control of human helminth infections
Lung produced surfactant protein D (SP-D) is essential for both homeostasis and as an innate immune opsonin. In the project presented here, we aimed to translate data recently published by our group, which demonstrated that SP-D contributes to protection against murine parasitic nematode …
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