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Showing 1 to 17 of 17 for “"in vitro analyses"”.
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Functional in vitro analyses of lipid raft-associated cathepsin b: implication for the invasive phenotype of inflammatory breast cancer
<p>FUNCTIONAL IN VITRO ANALYSES OF LIPID RAFT-ASSOCIATED CATHEPSIN B: IMPLICATION FOR THE INVASIVE PHENOTYPE </p> <p>OF INFLAMMATORY BREAST CANCER</p> <p>by</p> <p>BERNADETTE C. VICTOR</p> <p>December 2011</p> <p>Advisor: Dr. Bonnie F. Sloane</p> <p>Major: Cancer Biology </p> <p>Degree: Doctor of …
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A Mutational Analysis of Bacteriophage Lambda Site-Specific Recombination (In Vitro, Dna-Dna Interaction, Protein, Oligonucleotide-Directed)
Mutations within the lambda attachment (att) site were constructed by oligonucleotide-directed site-specific mutagenesis and analysed for their effects on site-specific recombination. The phenotype of mutations within the 15 base "core" region of sequence homology demonstrated that homology …
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In-Vitro-Untersuchungen an mikroverkapseltem humanem Nebenschilddrüsengewebe : Vorarbeiten zur Therapie des permanenten Hypoparathyreoidismus mittels Allotransplantation ohne Immunsuppression
… der Epithelkörperchen stellt eine gute Alternative zur konservativen Therapie des permanenten Hypoparathyreoidismus dar; dennoch konnten die bisherigen langfristigen Ergebnisse von anderen Gruppen nicht reproduziert werden. Die Standardisierung der Transplantationsparameter und …
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Molecular Physiology of the Chlamydomonas Pyrenoid
Operation of the CO<sub>2</sub>-concentrating mechanism (CCM) in the model green alga *Chlamydomonas reinhardtii* relies on confining Rubisco in a proteinaceous microcompartment, the chloroplastic pyrenoid. Despite a long history of research, this enigmatic structure lacks a full definition both in …
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Exploiting p53 mutation in colorectal cancer: clinical positioning of Cdc7 inhibitors
Mutations in TP53 are present in approximately 50% of colorectal cancer (CRC) and are enriched for in the metastatic setting. As a result of TP53 mutation these tumours are limited in their ability to execute tumour-suppressive functions. Synthetic lethal targeting of pathways/ proteins on which …
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Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
Cyclic AMP-mediated signaling pathways are important for maintaining metabolic homeostasis. The effects of cAMP are mediated mainly by protein kinase A (PKA) and the more recently discovered exchange protein directly activated by cAMP (Epac). Epac has two isoforms, the ubiquitously expressed Epac1 …
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Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
Cyclic AMP-mediated signaling pathways are important for maintaining metabolic homeostasis. The effects of cAMP are mediated mainly by protein kinase A (PKA) and the more recently discovered exchange protein directly activated by cAMP (Epac). Epac has two isoforms, the ubiquitously expressed Epac1 …
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Development and Characterization of Tunable, Bioinspired Electrospun Constructs for Skeletal Muscle Engineering
Volumetric muscle loss, as a result of high intensity sports injury, trauma or tumor ablation, affects more than 250,000 civilians each year in the U.S. alone and accounts for more than 50% of all DoD disabilities. These injuries often leave patients with permanent structural and functional …
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Structural Characterization And Bioactivity Of Cranberry Oligosaccharides
… sources, such as the fruits of cranberry (Vaccinium macrocarpon Aiton), promote human health in a variety of ways. However, complete studies of carbohydrate function often hinge on a detailed understanding and thorough elucidation of the chemical structure. Several methods have been used in the …
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Retrotransposon-mediated instability in the human genome
LINE-1 (Long Interspersed Element-1/L1) and Alu are two active retrotransposon families in the human genome that have the potential to create genomic instability either during the insertion of new elements or through ectopic recombination. However, recent in vitro analyses have demonstrated that …
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Evolutionary and Paleobiochemical Analyses of Heme Peroxidases
… of enzymes with desirable characteristics for industry. The approach presented here, applied to the heme peroxidases, marries bioinformatic methods with evolutionary theory and biochemical validations. Heme peroxidases catalyse the oxidation of a variety of electron donors by hydrogen peroxide. …
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Investigating Hfq-Mrna Interactions In Bacteria
… (sRNAs) are essential for bacteria to thrive in diverse environments and they also play a key role in virulence [11]. Trans-sRNAs affect the stability and/or translation of their target mRNAs through complementary base-pairing. The base-pairing interaction is not perfect and requires the …
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MicroRNA-mediated Attenuation of Inflammation in NZB/W Lupus Mice
… and deposition of nuclear self-antigen-containing immune complexes. Epigenetic factors, including altered microRNA (miRNA) expression, may contribute to aberrant immune cell function in SLE. miRNAs are small, noncoding RNAs that bind to the 3’ untranslated region of target mRNAs resulting in …
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Programmed cell death-ligand 1 (PD-L1) expression in HIV-associated diffuse large B-cell lymphoma – role and regulation
… is an aggressive disease that displays striking heterogeneity at both the molecular and clinical levels; and as a result, up to 40% of patients relapse or are refractory to standard first-line therapy. DLBCL is the most common subtype of lymphoma affecting people living with HIV …
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Porous calcium phosphate granules for biomedical applications
… field that has been the subject of more and more interest in many areas of research and especially in the development of new biomaterials. The rise in the average age of the world population, increasing osteoporosis treatments and the spread of cancer and genetic bone diseases, has brought about …
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EXPLOITATION OF ANTIOXIDANT BIOACTIVE COMPOUNDS FROM AGRO-INDUSTRIAL BY-PRODUCTS
This PhD project aimed to investigate how different agro-industrial by-products can be exploited to obtain extracts enriched with bioactive compounds that possess antioxidant and antiradical properties. For this purpose, plant parts that are generally discarded because they are recognized as waste …
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REGENERATIVE MEDICINE STRATEGIES FOR ENDOMETRITIS IN REPRODUCTIVE MARES:IN VITRO AND IN VIVO STUDIES
Endometritis is a fertility-impairing pathology frequent in reproductive mares. Persistent post-breeding induced endometritis (PPBIE) is caused by a uterine inflammatory imbalance, while chronic degenerative endometritis (CDE) involves endometrial fibrotic alterations and has been associated with …