Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 240 for “"in utero"”.
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Modulation of lung development by In utero gene transfer
Advances in prenatal diagnosis of genetic and congenital disorders with progressively more sensitive techniques may increase opportunities for consideration of prenatal gene therapy. There are a number of genetic and acquired disorders with peri or postnatal pulmonary manifestations. These include …
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A metabolomics investigation of in utero antiretroviral exposure to neonates
This thesis, with the title "A metabolomics investigation of in utero antiretroviral exposure to neonates", deals with the concern over adverse metabolic consequences reported for some neonates prenatally exposed to antiretroviral treatment (HIV-ART). The pandemic due to HIV infection, the cause of …
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Understanding Ontogeny and Optimizing Strategies to Promote Hematopoietic Engraftment Following In Utero Transplantation
Early diagnosis and in utero hematopoietic stem cell transplantation (IUHSCTx) have the potential to reduce fetal/neonatal morbidity/mortality due to hematological and immunological disorders. In some instances, IUHSCTx could also prevent disease-dependent organ damage/failure that many genetic …
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Making In Utero Gene Therapy Safer and More Efficient: A First Step Towards Clinical Realization
… to treat and cure some of the most devastating diseases affecting humans. Monogenic disorders are the ideal target for developing and testing gene therapy procedures that will allow correction of genetically-based diseases. In this study gene therapy tools were developed and evaluated in an …
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Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
Many antiepileptic drugs on the market, including valproic acid (VPA), have a wide range of therapeutic effects in addition to treating epilepsy. In recent years, the use of VPA in the treatment of psychiatric conditions has been on the rise. However, studies have shown that in utero exposure to …
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The Neurotrophic Influence on Craniofacial Development Subsequent to in Utero Unilateral Transection of the Trigeminal(V) Nerve
… of the root (sensory and motor) of the trigeminal(V) nerve and/or Gasserian ganglion was produced unilaterally in Long-Evans rat fetuses in utero at 17.5, 18.5, and 19.5 days of gestation to delineate the role of the trigeminal(V) nerve in the regulation of cellular differentiation, tissue …
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VALUTAZIONE DI UNA NUOVA TECNICA CHIRURGICA PER LA CORREZIONE IN UTERO DELL'ERNIA DIAFRAMMATICA IN UN MODELLO ANIMALE: RISULTATI PRELIMINARI.
… is to evaluate a new surgical technique for the in utero correction of the diaphrgmatic hernia (CDH) obcluding the left main bronchus in an animal model (sheep). The first part of the project will be based on the examiantion of the anatomy of the trachea and main bronchi. On the basis of the …
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Assessing fetal topoisomerase IIα as a mechanism of in utero benzene toxicity in generating double-stranded DNA damage in CD-1 mice
… evidence has shown that benzene exposure during pregnancy is associated with increased infant leukemias after birth. It is hypothesized that these leukemias are being initiated in utero by benzene exposure during pregnancy. The metabolite 1,4-benzoquinone (BQ) specifically inhibits the …
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Rumen-protected Lysine fed to Holstein cows prepartum and in utero effects on their offspring during the first 56 days of life
… pivotal to provide adequate concentrations of amino acids (AA) in the prepartum diet for the cow’s health and performance. However, less is known about the potential in utero effects of particular AA on the early-life performance of calves. This experiment was conducted to determine the effects …
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Development of a 3D radial MR Imaging sequence to be used for (self) navigation during the scanning of the fetal brain in utero
Imaging the fetal brain in utero is challenging due to the unpredictable motion of the fetus. Although ultra-fast MRI sequences are able to image a 2D slice in under a second, thus limiting the time in which fetal motion can corrupt images, Cartesian sampling makes these sequences sensitive to …
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Auswirkungen der in-utero-Nikotinexposition auf kardiorespiratorische Phänomene während des ersten Lebensjahres : polysomnographische Vergleichstudie einer Referenzgruppe mit einer Studiengruppe mittels linearer und logistischer Regressionen
Sudden infant death generally occurres at night during sleep with a peak incidence in the second and third month of life. Since the autoregulative maintenance of cardiorespiratory functions at this stage is very important, sleep studies seem a promising tool in the investigation of the causes of …
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Effect of nicotine and alcohol exposure in utero on vascular intima medial thickness, endothelial function, and the development of cardiometabolic risk factors in children in a low-income setting.
Introduction: Foetal exposure to nicotine and alcohol during pregnancy may result in cardiovascular disease (CVD) later in life. In low socioeconomic regions, CVD risk factors have also presented in children and adolescents. The Developmental origins of Health and Disease (DoHaD) hypothesised that …
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Association of early-life tobacco exposure with Cardiovascular-Kidney-Metabolic (CKM) syndrome risk : is accelerated biological aging a mediating pathway?
Early-life tobacco exposure, including in utero exposure and early smoking initiation, is a well-established risk factor for age-related diseases, but its associations with proteomic aging and Cardiovascular-Kidney-Metabolic (CKM) syndrome severity, and whether optimal modifiable risk factors can …
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The nature, extent, and range of evidence of the premature constriction or closure of the ductus arteriosus in utero unrelated to known non-steroidal-anti-inflammatory drug exposure: a scoping review
Background: During pregnancy, the ductus arteriosus allows blood to bypass the fetal lungs. Non-steroidal anti-inflammatory drug (NSAID) use in late pregnancy can cause premature constriction or closure of the ductus arteriosus (PCDA), though cases also occur without NSAID exposure. Understanding …
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Antiandrogens and Development of the Male Rat Reproductive Tract
… exposure. The objectives of this thesis were to investigate the development of male reproductive tract malformations secondary to in utero DBP exposure from the fetus to the adult, to characterize the effects of DBP on fetal testicular gene expression for the steroidogenic enzymes, and to further …
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