Global ETD Search
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Showing 1 to 1 of 1 for “"in situ click chemistry"”.
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Development of biotin protein ligase inhibitors from Staphylococcus aureus as new antibiotics
Biotin protein ligase (BPL) catalyses the ordered reaction of biotin and ATP to give biotinyl-5’-AMP 1.03, which then activates a number of biotin dependent enzymes that are critical to cell survival. Research undertaken in this thesis highlights strategies to selectively inhibit Staphylococcus …