Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"impaired glucose tolerance"”.
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The effect of lifestyle modification on the insulin-signaling cascade among subjects with impaired glucose tolerance
Impaired glucose tolerance(IGT) is characterized by insulin resistance and lifestyle modification is considered to have positive effects on glycemic control and reducing the risk of diabetes. Recently, defects in the insulin-signaling cascade, especially PI-3 kinase pathway, have been implicated in …
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Peripheral polyneuropathy in type 2 diabetes mellitus and impaired glucose tolerance. Correlations between morphology, neurophysiology, and clinical findings
… nerve fiber loss in type 2 diabetes and impaired glucose tolerance (IGT), in relation to glucose dysmetabolism, and clinical and neurophysiological measures of PN. Methods: Subjects were recruited from a prospective, population-based study of males from Malmö, Sweden (6956 responders). …
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Oligomeric cocoa procyanidins possess enhanced bioactivity compared to monomeric and polymeric cocoa procyanidins for preventing the development of obesity, insulin resistance, and impaired glucose tolerance during high-fat feeding
… on the onset of obesity, insulin resistance and impaired glucose tolerance and to determine the impact that the size of these compounds has on the magnitude of this effect. Cocoa extract was fractionated into a monomer-, an oligomer-, and a polymer-rich fraction. Six groups (n=9) of C57BL/6J mice …
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Retrospective analysis of pregnancies at the Grootte Schuur Hospital : a comparison of pregnancy outcomes in pre-gestational and gestational diabetes
Although the treatment of gestational impaired glucose tolerance (GIGT) has been shown to be beneficial, the cost implications in treating GIGT in resource constrained economies needs examination. Thus this study assessed: (i) pregnancy outcomes in pre-gesational types 1 and 2 diabetes (DM) with …
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Adiponectin deficiency leads to hepatic steatosis and contributes to the development of gestational diabetes mellitus
… of pregnancy, characterized by hyperglycemia and impaired glucose tolerance with first onset mid-gestation. Genetic predisposition, maternal obesity and diet contribute to development of GDM. In addition, low levels of serum adiponectin are associated with increased risk for GDM. Adiponectin is an …
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Genetic and Molecular Analysis of Islet-and Liver-Enriched Transcription Factors in Metabolism and Development
… genetic defects in the glucokinase gene, the glucose sensor of the pancreatic β-cells, and the insulin gene also lead to impaired glucose tolerance. Using molecular and genetic approaches, we demonstrated that the MODY genes are functionally related and form an integrated transcriptional …
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Metabolic Syndrome, Inflammation, Heart Rate Variability, and Fitness in Obese African American Youth
… and fasting and 2-hr postprandial insulin and glucose levels obtained during a mixed meal tolerance test for determination of impaired glucose tolerance and insulin resistance. Aerobic fitness was assessed by cardiopulmonary maximal treadmill exercise using the Branching Protocol …
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Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
… density, and insulin+ cell frequency, as well as impaired glucose tolerance and increased pancreatic leukocyte infiltration. This model will be used in future studies to lineage-trace CK19+ cell contribution during hMSC CM-induced islet regeneration.
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Glucose tolerance, plasma insulin, and plasma glucagon in relation to obesity in chickens
Relationships among glucose tolerance, plasma insulin, and plasma glucagon were examined in chicks developed through selection for high (HW) and low (LW) body weight, and in F, crosses (HL) between HW males and LW females. At 21, 42, 63, and 84 days of age, chicks from each population were …
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The metabolic and environmental determinants of obesity in childhood: observational and interventional studies
… risk factors such as hypertension and impaired glucose tolerance are prevalent in up to 30% of obese children whilst psychological impairments such as low self-esteem and depression are also commonly observed. Numerous factors have been implicated in the development of obesity, and …
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Early Manifestation of Cardiovascular Disease Risk Factors in Offspring of Mothers with Previous History of Gestational Diabetes Mellitus
… of GDM mothers and 96 offspring of mothers with impaired glucose tolerance [IGT]) participated in the study. CVD risk factors included elevated body mass index (BMI), skinfold thickness, body fat, blood pressure, lipid profiles, and glucose values measured with a 2 h oral glucose tolerance test. …
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The effect of glucose regulation on cognitive functioning in a healthy sample of older adults
Type II diabetes and impaired glucose tolerance (IGT) are both associated with cognitive impairment and an increased risk of dementia, and normal aging has been shown to be accompanied by abnormalities in glucose regulation. The present study was conducted to determine if variations in cognitive …
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The prevalence and risk factors of diabetes mellitus among tuberculosis patients at Ubuntu clinic, Khayelitsha
… which sought to assess the prevalence of DM and impaired glucose tolerance (IGT) and determine the risk factors associated with DM among TB patients. Methods: This cross sectional study forms part of a case control study that aimed to assess the association between DM and TB and the population …
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Defining Ankyrin-b Syndrome: Characterization of Ankyrin-b Variants in Mice and Men and the Discovery of a Role for Ankyrin-b in Parasympathetic Control of Insulin Release
… early senescence, reduced lifespan, and impaired glucose tolerance. This constellation of traits is known as ankyrin-B syndrome, which may have important implications for humans possessing functional ankyrin-B mutations. We found that ankyrin-B variants are surprisingly common, ranging …
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Risk faktors for fracture in middle-aged men and women
… fractures frequently cause long-term disability, impaired quality of life and sometimes death. The Malmö Preventive Project, a population-based, prospective study, consisting of 22 444 men, mean age 44 and 10 902 women, mean age 50 years, provides data for evaluation of common public health …
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Acute Impact of Non-Sugar Sweeteners on Glycemia in Middle-Aged and Older Adults with Prediabetes
… coincidentally at increased risk of developing impaired glucose tolerance. However, the understanding of how individual NSS impacts glycemia in this at-risk population is unknown. The objective of these two different three-group randomized crossover studies was to determine if the intake of …
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Applications of Proton Transfer Reaction and Selected Ion Flow Tube Mass Spectrometry in Health Monitoring
… including pancreatic secretion. These mice show impaired glucose tolerance. The gut microbiota of diabetic mice appear to have a different composition when compared to wild-type littermates, i.e. significantly increased levels of short-chain fatty acids (SCFAs), ketones, alcohols and aldehydes …
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Relationships of gastric emptying with glycaemia, insulin secretion and the incretin effect in health and type 2 diabetes
… with gastric emptying in subjects with normal glucose tolerance, impaired glucose tolerance and type 2 diabetes. 2) Evaluation of the relationships of the insulin secretory response and the oral disposition index with gastric emptying in subjects with normal glucose tolerance. 3) Utilisation of …
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The effect of apolipoprotein E (APOE) genotype and long chain omega 3 fatty acids on body weight and inflammation
… APOE3, but not APOE4, mice develop obesity and impaired glucose tolerance upon HFD feeding that is prevented by dietary fish oil. ATM infiltration and phenotype was similar between APOE3 and APOE4 mice. Fish oil increased the number of ATM without influencing their phenotype. LC n-3 PUFA …
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