Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"impact on host"”.
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VIRUS-HOST INTERACTIONS AND THE IMPACT ON HOST CELLULAR MECHANISMS
Paramyxoviridae constitutes an RNA-genome virus family that includes the emergent and deadly Nipah (NiV) and Hendra (HeV) viruses. These viruses possess substantial pandemic potential and exhibit an expansive host range, a characteristic underpinned by their conserved ephrin receptors. Being a …
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Shifting disease dynamics following the invasion of an emerging wildlife pathogen
The introduction of pathogens to new regions can have significant impacts to human, agricultural and wildlife health. Introduced pathogens can change and adapt to new hosts (i.e. the species that they infect) and to new habitats. These factors can ultimately influence their impact on host …
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Occurrence and Impact of the Asian Fish Tapeworm Bothriocephalus acheilognathi in the Rio Grande (Rio Bravo del Norte)
… as an incidental hitchhiker of its native host, Ctenopharyngodon idella (Andrews et al. 1981; Hoffman 1999). It is established in ten states in USA with the most recent discovery in the Rio Grande in Texas (Bean et al. 2007). Occurrence of this exotic tapeworm in the Rio Grande potentially …
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Occurrence and Impact of the Asian Fish Tapeworm Bothriocephalus acheilognathi in the Rio Grande (Rio Bravo del Norte)
… as an incidental hitchhiker of its native host, Ctenopharyngodon idella (Andrews et al. 1981; Hoffman 1999). It is established in ten states in USA with the most recent discovery in the Rio Grande in Texas (Bean et al. 2007). Occurrence of this exotic tapeworm in the Rio Grande potentially …
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Inscribing Violence: Quantifying the Impact of World Heritage Site Inscription on Direct and Structural Violence.
<p>The World Heritage Program and nomination process have undergone considerable criticism regarding their impact on host nations. These critics have often described violence as an unintended side-effect of heritage sites, but this research has lacked a systematic analysis of types of violence …
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Molecular Mechanisms Behind Sars-Cov-2 Induced Host Genome Restructuring
<p>Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) has caused unprecedented morbidity and mortality worldwide.<strong> </strong>There are two pathophysiological hallmarks associated with severe patient outcomes after SARS-CoV-2 acute infection, namely delayed/weakened interferon …
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The gut microbiome of the wild great tit (Parus major): drivers and fitness consequences
The gut microbiome plays a vital role in its host’s ecology. Clinical studies have shown gut microbes increase host health and fitness by providing digestive and immune functions, as well as aiding development. Natural variation in the microbiome is widely believed to affect host fitness in the …
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Targeted destruction of intracellular DNA using a CRISPR-based genetic device that can be carried indefinitely in the host genome
Environmental release of synthetic DNA resulting from the disposal of spent microbial biocatalyst potentially represents an ecological risk to the environment or a financial risk to biotechnology firms, who might have their intellectual property stolen as a consequence. Thus, a genetically-encoded …
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Sequence-Dependent & -Independent Effects of Intron-Mediated Enhancement (IME)
Introns are ubiquitous features of eukaryotic genes, and their precise removal from pre-mRNA transcripts by the spliceosome is an essential step in gene expression. Genomic deletion of an intron from a gene tends to reduce its expression, and addition of an intron tends to increase it. This …
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Mobile genetic element contribution to the genome architecture of the human parasitic flatworm Schistosoma mansoni
… disease that affects approximately 250 million individuals worldwide, resulting in an estimated loss of more than 20 million disability-adjusted life years. Around 700 million people, predominantly in developing countries, live in at-risk areas. Schistosomiasis is caused by trematodes of the …
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Identification of host factors required for cytosol entry by Shigella flexneri: Results of a genome-wide CRISPR/Cas9 screen
… mortality. *Shigella* induces its uptake into colonic epithelial cells via a short-lived vacuole, and lyses the vacuole membrane to gain entry to the host cytosol. As a professional cytosol-dwelling pathogen, *Shigella* then overcomes cell-autonomous host defences to establish its replicative …
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Phylogenetic and functional characterization of human microbiome intra-species diversity and tracking of early-life transmission
The human gut is colonized by a vast bacterial community that is currently rather well characterized at the species level. Yet, each of these species harbor a tremendous amount of individual genetic variations. Our understanding of the human gut microbiome, its dynamics, composition and impact on …
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Understanding the role of phages in the mammalian gut microbiome
… microbial community that regulates immune responses, defends against pathogens, maintains gut barrier integrity, and modulates metabolic processes. Disruptions of the balanced microbial community, followed by effects on host health, often called dysbiosis, have been associated with alterations …
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Viral diversity and host-virus interactions in the model crenarchaeon Sulfolobus islandicus
Viruses are pervasive evolutionary forces and key players shaping natural populations. Our understanding of viral impact on host physiology however, is based on a few model systems that represent a small fraction of the life-history strategies employed by hosts or viruses across the three domains …
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Deciphering the relationship among nutrition, host and microbe
… human gastrointestinal tract, there are trillions of resident microbes collectively known as the gut microbiota. These organisms have a profound impact on host physiology, particularly the immune system. Upon birth, the gut microbiota begins to take shape with input from various influences …
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DEVELOPMENT OF INNOVATIVE INSECT MEALS AS FUNCTIONAL FEED INGREDIENTS FOR MONOGASTRIC ANIMALS
The global population is facing exponential growth, projected to exceed 9 billion by 2050, raising significant challenges for food security and sustainability. This rapid increase drives higher demand for food, particularly animal-based products, placing pressure on the agricultural and livestock …