Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 95 for “"immunotherapeutic"”.
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Research towards novel immunotherapeutic vectors: calixarene scaffolds
… allow them to be potential adjuvants for cancer immunotherapeutics.
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ARMING STRATEGIES TO IMPROVE THE IMMUNOTHERAPEUTIC POTENTIAL OF ONCOLYTIC HERPESVIRUSES
… and advancing the development of more potent immunotherapeutic approaches for cancer treatments.
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Characterizing ALCAM as an oncoprotein and immunotherapeutic target in neuroblastoma
… remains a critical need for discovery of new immunotherapeutic targets. ALCAM is a cell-surface cell adhesion protein that is more highly expressed in neuroblastoma than a majority of human cancers. Previous studies have implicated ALCAM overexpression in adult cancer growth and metastasis, …
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Efficacy of novel immunotherapeutic strategies targeting L1CAM in pancreatic cancer
… the potential of L1CAM as a target for immunotherapeutic therapies, with L1CAM-ADC demonstrating effective immunotherapeutic approach in therapy of even advanced PDAC.
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Targeting TNFSF10 as a novel immunotherapeutic strategy in Alzheimer’s disease
Alzheimer’s disease (AD) is the most common cause of dementia worldwide, characterized by extreme unmet needs and a huge disease burden. Cerebral atrophy, amyloid plaques, and neurofibrillary tangles represent the main pathological characteristics of the AD brain. Despite remarkable research …
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Immunotherapeutic Strategies to Reverse Tumor Associated Immunosuppression in Breast Cancer
<p>Heterogenous cancers such as breast carcinoma, would highly benefit from personalized vaccine approaches such as autologous tumor cell vaccines (ATCVs). By using cancer cells that are isolated from self, this approach has the potential to generate a polyclonal immune response against tumor …
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Cell separation and cryopreservation of cord blood fractions for immunotherapeutic applications
In 2008 Anthony Nolan opened the UK’s first public umbilical cord blood (CB) bank (Anthony Nolan Cell Therapy Centre, ANCTC) in which CB is stored for haematopoietic stem cell (HSC) transplantation. Due to strict quality thresholds, the majority of units are not suitable for transplantation. …
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Investigating breast cancer O-linked glycosylation changes and their immunotherapeutic potential
Changes that occur in malignant cells can take a variety of forms and include changes in cellular glycosylation. Aberrant glycosylation is considered to be a universal feature of malignant transformation and tumour progression. Mucins are major carriers of altered glycans in most carcinomas, and …
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Investigating toll-like receptor agonists as an immunotherapeutic for metastatic osteosarcoma
… of toll-like receptor agonists as an immunotherapeutic for canine osteosarcoma. From a comparative and translational perspective, the long-term goals of this research include not only the treatment of canine osteosarcoma, but also human osteosarcoma, as this disease has numerous …
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Molecular expression and immunotherapeutic potential of the novel tumour associated antigen T21
The application of immunotherapeutic approaches to target tumour cells by harnessing the body’s most important defence the immune system, could provide opportunities to oppose cancer. A prerequisite of tumour immunotherapy lies in the identification of antigens that are distinctively expressed in …
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Modulating SIRP-alpha, a Myeloid-Specific Immune Checkpoint, for Immunotherapeutic Treatment of Malignancy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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HMGB1- An Immunotherapeutic Target for the Treatment of Neonatal Sepsis and Associated Neuroinflammation
Neonatal sepsis remains one of the leading causes of death in the neonatal intensive care unit. Preterm infants and infants with very low birthweight are at increased risk of sepsis and its associated morbidities. Whilst developments in supportive care and antimicrobial advancements have decreased …
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Assessing the Efficacy of Interleukin-7 as an Immunotherapeutic in the SIV+ Rhesus Macaque Model
Human Immunodeficiency Virus (HIV) infection is known for depleting ‘helper’ CD4+ T cells. Highly active antiretroviral therapy (HAART) reduces viremia and increases CD4+ levels, however, 5-20% of patients fail to reconstitute CD4+ T cell levels despite viral suppression. Interluekin-7 (IL-7), a …
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Immunotherapeutic alteration of tumor-induced suppression of interleukin 2 and 3 production by Propionibacterium acnes vaccination
Previous reports indicate that anti-tumor activity arising from systemically injected P. acnes is macrophage-mediated, whereas anti-tumor activity arising from locally injected P. acnes is T cell-mediated. It is possible these P. acnes-induced cytotoxic T cells arise via the Interleukin cascade. …
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Modelling pancreatic cancer in vivo with patient derived organoids & humanised mouse models for the investigation of immunotherapeutic treatment response
Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent form of pancreatic cancer, with a median survival time of <11 months. While incidences of PDAC continues to rise, treatment options remain limited and largely ineffective. The complex genomic, microenvironmental and immunophenotypic …
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Blocking Immunosuppressive Factors and Taking Advantage of the Nutrient Supply Within the Tumor Microenvironment: Pathways to Achieve Improved Cancer Immunotherapeutic Efficacy for Patients With Metastatic Melanoma
The incidence of melanoma is increasing. Immunotherapy commonly fails due to the immunosuppressive tumor microenvironment (TME). The aim of my dissertation is to develop strategies that dampen the TME’s immunosuppressive capacity and improve the antitumor performance of vaccine-induced …
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Paclitaxel-induced macrophage activities in the tumor-bearing host: immunologic implications and therapeutic applications
… and interleukin-1b. In contrast to its apparent immunotherapeutic effect on Mf populations, paclitaxel's cytostatic mechanisms suppress lymphocyte proliferation and function. We showed that IL-12 can reverse paclitaxel-mediated suppression of T-cell responses in vitro, establishing the foundation …
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Novel urinary and serological markers of prostate cancer using proteomics techniques: an important tool for early cancer diagnosis and treatment monitoring
… our cohort and potential cancer diagnostic and immunotherapeutic inferences were drawn. Using these approaches, we identified 5595 and 9991 non-redundant peptides from the pooled and individual experiments respectively. While nine proteins demonstrated ethnic trend, 37 and 73 proteins were …
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T Cell Exhaustion in Glioblastoma
… T cell exhaustion and thus sensitize GBM to immunotherapeutic strategies. In Chapter 6 we describe the mechanism driving T cell exhaustion and reveal a novel mechanism by which T cell based immunotherapies may recognize and kill tumor cells. In summary, this original work provides several …
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