Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 213 for “"immunosuppression"”.
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Mechanisms of Immunosuppression in Murine Malaria
An extract was prepared from Plasmodium berghei, NK65C strain, by disrupting P. berghei infected erythrocytes with a Parr bomb disruption cell. This extract was capable of reducing the anti-DNP and SRBC plaque forming cell response of mice intraperitoneally injected with the extract one day prior …
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Glioblastoma: multifaceted immunosuppression mediated through galectin family members
… may be a key mechanism through which GBM immunosuppression is mediated. These results posit the perivascular region as a uniquely immunosuppressive environment, and the presence of galectins as a potential key mediator of immunosuppression within glioblastoma.
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Effects of nNOS Inhibitors on Melanoma-Induced Immunosuppression
… the effects of nNOSi on melanoma-induced immunosuppression of T cells. Fresh whole blood samples were collected from 11 disease-free human donors (7 male, 10 Caucasian) between the ages of 20 – 40 years old. CD3<sup>+</sup> T cells derived from peripheral blood mononuclear cells (PBMCs) …
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Roles For Braf Kinase Activating Mutations In Melanoma: Microenvironmental Immunosuppression
<p>The BRAF oncogene demonstrates a characteristic mutation (V600E) in a significant fraction of cutaneous melanomas, leading to constitutive activation of the MAP kinase pathway. This genetic lesion endows tumor cells with proliferative and survival advantages, and metastatic melanoma patients …
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Immunotherapeutic Strategies to Reverse Tumor Associated Immunosuppression in Breast Cancer
… we addressed the MDSC associated immunosuppression, by investigating strategies to facilitate the maturation of immature immune cells. We considered different commercially available toll like receptor (TLR) agonists namely Pam3CSK4 (Pam), Poly (I:C), lipopolysaccharide, FLA-ST, …
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Anticonvulsant drugs in immunosuppression and carcinogenesis / by Tania C. Sorrell
[20] 172 [45] leaves
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Investigating immunosuppression as a disease modifying strategy in Parkinson's disease
… of the potential effect of peripheral immunosuppression with azathioprine on neuroinflammation. This chapter also shows a correlation between peripheral NK populations and whole brain [11C]- PK11195 signal. Chapter 5 uses multiple regression analysis to explore the contribution of these …
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Regulation of macrophage activities by tumor growth: mechanisms of immunosuppression
Macrophages (Mφ) are a major immune cell involved in anti-tumor responses. Mφ activities such as tumor cytotoxicity. presentation of tumor-associated antigens, and stimulation of anti-tumor lymphocytes are all involved in the battle against tumor growth. However, other Mφ activities such as cell …
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Parp Inhibitor Upregulates Pd-L1 Expression and Enhances Cancer-Associated Immunosuppression
… a crosstalk between PARPi and tumor-associated immunosuppression, and provides a rationale for the combination of PARPi and PD-L1 or PD-1 immune checkpoint blockade as a potential therapeutic approach. (Jiao et al., 2017)</p>
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Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression during Immunotherapy
<p>Tumors are dynamic ecosystems that evolve under selective pressures, shaping their ability to either elicit or evade immune responses. In pancreatic ductal adenocarcinoma (PDAC), where immunotherapy has yet to become an effective treatment option, we investigated the role of intratumoral …
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The role of stromal cells in the establishment of Glioblastoma tumour microenvironment immunosuppression
… due to one of GBM’s key hallmarks - its profound immunosuppression. This is established through the immunosuppressive phenotypes and secretions of cells within the tumour microenvironment (TME). The TME comprises a mixture of malignant tumour cells, stroma, blood vessels and infiltrating immune …
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Studies of the Host Response and the Induction of Immunosuppression in Murine Malaria
Various fractions were separated from Plasmodium berghei infected erythrocytes and tested for suppression of the immune response to SRBC. Membranes containing fractions Peak I (C), Peak I (G), and the sodium deoxycholate void volume all act as a vaccine against Plasmodium infection and are all …
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Tumor-induced immunosuppression: Contribution of a high molecular weight inhibitor and Prostaglandin E2
… in the TBH, but not in the normal host. Thus, immunosuppression in the TBH was at least partly due to the inability of Mac-1⁺ and/or Mac-3⁺ Mφ to control production of PGE; by Mac-2⁺ Mφ, which then acts in conjunction with the high mw inhibitor to stop T cell proliferation.
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Targeting immunosuppression in the tumor microenvironment and protein-based antagonism of oncogenic K-Ras
… cytokine interleukin-2 (IL-2), and reduce immunosuppression in the tumor microenvironment, via blockade of either transforming growth factor-p (TGF-[beta]) or phosphatidylserine. We performed in vitro characterization and extensive preclinical evaluation of our constructs in syngeneic …
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Uncovering Molecular Targets to Overcome Immunosuppression In Non-Small Cell Lung Cancer With Acquired Tki Resistance
… targets, like IL-6 and estrogen, in promoting immunosuppression in NSCLC tumors with acquired resistance to an EGFR-TKI or anti-VEGF therapy. Using preclinical in vitro human NSCLC cell lines and in vivo murine NSCLC models in addition to clinical samples from patients with NSCLC tumors, this …
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Dissecting the Role of Hedgehog Signaling in Tumor-associated Macrophages and Immunosuppression in the Tumor Microenvironment
… the role of hedgehog signaling in TAMs and immunosuppression within the TME in order to identify novel cancer therapeutic strategies.</p>
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The influence of carrageenans on the cells and pathways of haemostasis and their role in immunosuppression
Carrageenans are a group of galactan sulphates derived from marine Rhodophyceae. These polymers have been shown to exert a variety of pharmacological effects, several of which involve alterations in both immune and haemostatic responses. Carrageenans were studied for the following …
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