Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 72 for “"immunostimulatory"”.
-
IMMUNOSTIMULATORY FUNCTIONS OF ADENOVIRIONS AND FIBER PROTEIN.
IMMUNOSTIMULATORY FUNCTIONS OF ADENOVIRIONS AND FIBER PROTEIN.
-
Immunostimulatory activity and antitumor efficacy of mSOT201 immunocytokine
Cytokine-based therapies of malignant diseases are often limited by dose-dependent systemic toxicity and low efficacy. Here, we evaluated mSOT201 immunocytokine consisting of an IL-15 mutein linked through short flexible oligopeptide linker to IL-15Rα sushi+ domain and fused to the C-terminus of …
-
Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides
Immunostimulatory oligodeoxynucleotides (ODN) containing unmethylated CpG motifs are powerful stimulators of innate as well as adaptive immune responses, exerting their activity through the triggering of the endosomally localized TLR9 by a poorly understood mechanism. The immunopotency and broad …
-
Immunostimulatory and Cellular Toxic Effects of Single-Stranded RNA On Cancer Cells
… (5 '-ppp-ssRNA) is immunostimulatory was controversial in the literature. In order to clarify the immunostimulatory effect of 5'-ppp-ssRNA, we synthesized ssRNAs and tested the IFNp (interferon-beta) level and cellular toxicity of ssRNAs in SKOV3 cells. In this work, …
-
The Safety and Immunostimulatory Properties of Amorphous Silica Nanoparticles <10 nm in Diameter
Humans are exposed to high levels of amorphous silica on a daily basis, via the diet and the use of cosmetic and pharmaceutical products. Amorphous silica particles (10-200 nm) have also been developed for use in biomedical applications, including as binding agents in tissue repair, drug and gene …
-
Investigating the mechanisms behind the immunostimulatory activity of influenza A virus RNA polymerase mutations
… as both an innate immune agonist by producing immunostimulatory RNA species, and as an antagonist by directly interacting with the components of the RIG-I signalling pathway. However, the mechanisms underlying these roles of the viral polymerase in the IAV infection cycle are not completely …
-
Investigation of the immunostimulatory activity and vaccine potential of lipid encapsulated plasmid DNA and oligodeoxynucleoties
… This thesis is focused on investigating the immunostimulatory potential of liposomal nanoparticulate (LN) formulations of pDNA (stabilized plasmid lipid particles; SPLP) and cytosine-guanine oligodeoxynucleotides (CpG-ODN; LN CpG-ODN), and examining their ability to act together as a …
-
Immunostimulatory effects and delivery of oligodeoxynucleotides containing CpG motifs (CpG-ODN) in neonatal broiler chickens
… objectives of this study were to investigate the immunostimulatory effect of CpG-ODN against Salmonella Typhimurium infection and the formulation and delivery of CpG-ODN by the in ovo route. Day-old broiler chicks or embryonated eggs (day 18th of incubation) received either 50 µg of CpG-ODN, 50 µg …
-
TUMOR-TARGETED RELEASE OF IMMUNOSTIMULATORY AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION OF IMIDAZOQUINOLINE-BASED PRODRUGS AND ANTIBODY CONJUGATES
… antitumor immune responses through the use of immunostimulatory drugs connected to monoclonal antibodies (mAbs) which serve as targeting units. Even though ISACs have already entered early phase clinical trials, they have demonstrated several drawbacks. In this thesis, the problems showed by …
-
Immunostimulatory effects of different aspects of aquaculture on the host response in the edible sea urchin, paracentrotus lividus
… objective of this thesis was to look at the immunostimulatory effects of different aspects of aquaculture on the host response of the edible sea urchin, Paracentrotus lividus, which are a prized delicacy (roe) in many Asian and Mediterranean countries. In Chapter 1, the importance of …
-
Incorporation of CpG Oligodeoxynucleotides into α2-Macroglobulin: Development of a Novel Vaccine Adjuvant Delivery Mechanism
Bacterial DNA is immunostimulatory, and the motifs responsible for this activity are unmethylated CpG dinucleotides. Following cellular uptake, CpG-containing oligodeoxynucleotides (CpG ODN) are trafficked to the endosome where they bind Toll-like receptor 9 (TLR9) to initiate a signaling cascade …
-
Strategies for the induction of mucosal immunity against hepatitis B virus.
… due to the adjuvant effect of unmethylated immunostimulatory CpG motifs present in the DNA backbone. Synthetic oligodeoxynucleotides (ODN) containing immunostimulatory CpG motifs (CpG) are potent adjuvants for induction of Th1-like systemic immune responses against parenterally-delivered …
-
Identification of Coeliac Disease Triggering Glutenin Peptides and Their Measurement in Foods
… research has been carried out on the immunostimulatory components in wheat gliadin. Glutenins, newly discovered to be toxic to coeliac individuals, have limited evidence describing their immunostimulatory potential in coeliac disease. Glutenins can be further differentiated by their …
-
Innate Immunity in Chickens: In Vivo Responses to Different Pathogen Associated Molecular Patterns
… PGN common to all bacteria, MDP the smallest immunostimulatory unit of PGN, and poly I:C the dsRNA analog. PAMP recognition by and stimulation of the innate immune system is crucial to an individual’s ability to quickly limit microbial growth and stimulate the adaptive immune system. …
-
The Potential of Coelomocyte Chemotaxis as an Immune Biomarker in the Earthworm, Lumbricus terrestris
… solutions were described. Migration responses to immunostimulatory agents lipopolysaccharides (LPS), N-formly-methionyl-leucyl-phenylalanine (FMLP), sheep erythrocytes, Saccharomyces cerevisiae, Aeromonas hydrophila, Eisenia fetida and Rhabditis pellio were characterized. Chemotaxis was reported …
-
Paclitaxel-induced macrophage activities in the tumor-bearing host: immunologic implications and therapeutic applications
… mechanisms of paclitaxel-mediated cytotoxic and immunostimulatory responses by tumor-induced Mfs. Although tumor-derived factors, including interleukin-10 and transforming growth factor-b1, modulate Mf response to activation signals, paclitaxel partly reverses tumor-induced Mf-mediated …
-
Immunologic and Protective Effects of Vaccines for Mycobacterium marinum in Morone sp
… sp. antigen 85A (Ag85A) were assessed for immunostimulatory and protective effects against M. marinum. Because of their known susceptibility to piscine mycobacteriosis, Morone sp. were utilized as the models for these studies. The first study evaluated a recombinant vaccine with a Brucella …
-
The role of HLA-G in bone marrow transplantation
… properties were investigated in in vitro immunostimulatory and immunosuppression assays. Immunohistochemical analysis for HLA-G expression was performed in skin biopsies from allo-transplanted patients and correlated with the occurrence of graft-versus-host disease. We identified a CD14+ …
-
Dendritic Cells in Normal and Inflamed Human Skin
… (70 ± 4%), or BDCA-3+ (5 ± 1%), in order of immunostimulatory capacity. Only two myloid dendritic cell populations exist in normal human dermis: Lin-CD11c+HLA-DR+CD16+ and either BDCA-1+ (≈90%) or BDCA-3+ (≈10%). In situ double-label immunofluorescence showed that approximately 10-15% of …
-
Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
… environment. Recognition of a weakly immunostimulatory self-peptide was able to promote both thymic CD4+Foxp3+ Treg cell development and the formation of CD4+Foxp3+ Treg cells from CD4+Foxp3- T cell precursors in the periphery. Despite promoting Treg cell formation, this weakly …
Page 1 of 4