Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"immunoproteasome"”.
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Biochemical and computational studies towards selective inhibition of the immunoproteasome
… β1i, β2i and β5i subunits; forming the immunoproteasome (IP). The abundant CP is required for regular cell function, however due to upregulation in diseased states selective IP inhibition is associated with an increased therapeutic index. Recent identification of structural differences …
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Integrated cellular, proteomic and metabolite analysis of argyrin B with rational design approaches for immunoproteasome-selective inhibitors
… yet resistance and adverse effects persist. The immunoproteasome has recently emerged as an attractive and selective target due to its preferential expression in disease states. Here the constitutive proteasome (CP) active sites β1c, β2c and β5c are replaced with immunoproteasome isoform …
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Persistent “hijacking” of brain proteasomes in HIV-associated dementia
… analysis by immunoblotting showed increases in immunoproteasome subunits LMP7 and PA28 alpha and decreases in constitutive proteasome regulatory subunit Rpn2 in the frontal cortex of HIV-positive subjects that correlated with the abnormal proteasome proteinase profile and were associated with …
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Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis
… correlates with induction of IFNγ-inducible immunoproteasome subunits and is accompanied by increased HO-1 RNA; we also identified increased astrocyte immunoproteasome expression in these brains. In our in vitro models, prolonged exposure of human astrocytes, but not rodent astrocytes, to …