Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"immunophenotype"”.
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HIV-1 Transgenic Rats Display Alterations in Immunophenotype and Cellular Responses Associated with Aging
… age-matched controls. Our data indicate that the immunophenotype and immune responses can change during aging in HIV-positive individuals. This information could be important in determining the most beneficial age-dependent therapeutic treatment for HIV patients.</p>
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Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers
… et al.). exhibited constant (8 cell) immunophenotype. All the other categories exhibited mixed immunophenotype. The Working Formulation, with omission of the follicular tyoes (due to the rarity thereof in CML) and addition of the MMC category and immunophenotyping, is best for …
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Imunologiniai atvirų ir laparoskopinių prostatos vėžio operacijų skirtumai /
… We assessed the relationship between immunophenotype changes and clinical data (Gleason score, stage, positive margin, lympho-node status) as well as the risk of biochemical recurrence. We found, that Laparoscopic Radical Prostatectomy (LPR) technique resulted in complete restoration …
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Sporadic Burkitt Lymphoma in Adults; Clinico-pathologic Characteristics and Immunohistochemical Study
… We did immunohistochemical stains for immunophenotype determination and EBER-1 in situ hybridization (ISH) for evaluatin of relationship between EBV infection and BL. RESULTS: Among the 26 patients, there were 14 men and 12 women (median age: 40.5, range: 16-67 years). All patients were …
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Searching for the missing T Cell Receptor (TCR) in Anaplastic Large Cell Lymphoma (ALCL): Surplus to requirements or a protagonist in lymphomagenesis?
… considered the main driver. ALCL have an unusual immunophenotype; they rarely express a T cell receptor (TCR), but are often positive for CD4 and produce cytotoxic proteins such as perforin and Granzyme B, but in the absence of CD8, questioning the origin and pathogenesis of this malignancy. …
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KUPFFER CELLS¿ MITOCHONDRIAL PLASTICITY AFFECTS SYSTEMIC IMMUNO-METABOLISM
… preference toward carbohydrates, with an immunophenotype characterized by a higher proportion of pro-resolving KC2s than pro-inflammatory KC1s. Functionally, KCs also exhibit increased phagocytic and antigen-presenting ability, and a different proliferative capacity compared to controls …
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Dissecting The Mechanisms of Venetoclax Resistance In Myelodysplastic Syndromes
… of MDS patient stratification based on their immunophenotype in the clinical use of venetoclax-based therapy and assesses the feasibility of targeting MCL1 in venetoclax-resistant MDS patients as a novel therapeutic option to improve their survival.</p>
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Impact of Epa and Dha Supplementation and 15-Lox-1 Expression On Colitis and Colitis-Associated Colorectal Cancer
… biosynthesis from EPA and DHA to modulate immunophenotype, limit inflammation, promote resolution, and help prevent colitis and CAC. Mice were treated with dextran sodium sulfate (DSS) alone only to induce acute and chronic colitis, or with DSS following an azoxymethane injection to induce …
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Mitochondrial regulation of CD8+ T cell cytotoxicity
… as part of the Infection, Immunity and Immunophenotype Consortium and shown to display altered CTL killing. USP30 is a deubiquitinase localised on the outer mitochondrial membrane and on the peroxisomal membrane, where it counteracts mitophagy and pexophagy by cleaving ubiquitin chains …
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STUDY ON HISTONE DEACETYLASE 3 AND ITS PHARMACOLOGICAL REGULATION IN THE PATHOPHYSIOLOGY OF ADIPOSE TISSUE
… KO mice on adipocyte health, viability, and immunophenotype of adipose tissue; 3) study the effects of LA9498, a novel selective inhibitor of HDAC3, in comparison to MS275, a class I HDAC inhibitor which has already been characterized by our group, to evaluate the efficacy and the optimal …
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PRE-CLINICAL MODELING OF CELL AND GENE THERAPY OF FANCONI ANEMIA
… hematopoiesis and have reduced frequencies of immunophenotype-defined hematopoietic stem and progenitor cells (HSPCs), the number of functional stem cells within the impaired HSPC population remains unknown. Additionally, it is unclear whether current gene therapy approaches, aimed at …
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Characterization of human myeloid progenitors and their differentiation
… receptor (TpoR) in a previously presented immunophenotype definition of the human common myeloid progenitor (CMP), granulocyte/monocyte progenitor (GMP) and megakaryocyte/erythrocyte progenitor (MEP), significantly improved the separation of MEPs (TpoR+) from CMPs. Furthermore, it was shown …
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The immunopathogenic mechanism of severe cutaneous adverse reactions to first line anti-tuberculosis drugs
… and transcriptomic analyses, we aimed to immunophenotype different stages of the reactions. Methods We selected three groups of participants from the IMARI in Africa registry: i) HIV+ FLTD SCAR cases, ii) HIV- FLTD SCAR cases and iii) HIV+/- FLTD tolerant controls (>8 weeks on treatment …
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Analisi genetico-molecolare dei linfomi a cellule T periferiche
… great variety regarding either morphology, immunophenotype or clinical behavior. Specially, the molecular pathology of these tumors is still poorly known. In fact, many alteration were found, but no single genes were demonstrated to have a pathogenetic role. Recently, gene expression …
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Deciphering pre-leukaemic dysregulation caused by mutant C/EBPα at the level of the single cell
… by a plasmacytoid dendritic cell (pDC)-like immunophenotype. These cells were capable of long-term engraftment in a mouse model but did not recapitulate leukaemia for several months after transplantation. The second objective was to characterise the transcriptional deregulation associated …
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Immune Checkpoint Molecule Expression in Canine Lymphoma and Canine Reactive Lymphoid Hyperplasia
… determined using the 2^∆∆CT method. Lymphoma immunophenotype was assessed using immunohistochemical analysis of CD3 and CD79a (FFPE) and review of patient medical records (FNA). Data analysis included Wilcoxon ranksum tests, Dunn's procedure of multiple comparisons, Kruskal-Wallis tests, and …
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ROLE OF ASGR1 IN METABOLIC SYNDROME, OBESITY, AND ATHEROSCLEROSIS
… were assessed. Additionally, the circulating immunophenotype was measured. Results: ASGR1-/- present similar trends with the WT mice for galactosylation in complex glycans as well as α-2,3-linked sialylation, on mono-/diantennary glycans and in tri-/tetrantennary glycans while they present an …
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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia
… leads to a distinct gene expression profile and immunophenotype.</p> <p>Using viral overexpression and newly developed genetically engineered mouse models I have shown the effect of ZNF384 fusion expression at multiple stages of hematopoietic development in mouse and human systems. These …
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Defining CP-CML patient subsets associated with poor imatinib uptake and response.
… to 1) determine the variation in CP-CML patient immunophenotype at diagnosis, in relation to patient characteristics, including OA; 2) determine the gene expression patterns associated with OA, and identify new biomarkers for CP-CML; and 3) determine the global DNA methylation profile of CP-CML, …
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