Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"immunopeptidome"”.
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Characterising the immunopeptidome in hepatitis B
Characterising the immunopeptidome in hepatitis B Hepatitis B (HBV) is the leading cause of hepatocellular carcinoma (HCC) worldwide. There is presently no cure for HBV, and treatment options aim to reduce the risk of liver related complications and HCC. Immunotherapies have not been successful in …
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Quantitative mass spectrometry-based approaches for characterizing the immunopeptidome and tyrosine phosphoproteome in cancer
Significant advancements in proteome-based analyses stem from innovations in the field of mass spectrometry (MS), an analytical method which allows for the sequencing, identification, and quantification of peptides and proteins in complex biological mixtures. MS enables a molecular and systems-wide …
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Exploiting the Molecular Mechanisms of TAPBPR for use in Cancer Immunotherapy
… pathway, responsible for shaping the immunopeptidome via MHC-I peptide editing and the recycling of sub-optimally loaded MHC-I to the peptide loading complex. As such, TAPBPR plays an essential role in the activation of the immune system against infection and cancer, ensuring that only …
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A broadened HLA ligandome uncovers new immunotherapy targets for pancreatic cancer + A prime editor mouse to model a broad spectrum of somatic mutations
… The only prior study of the pancreatic cancer immunopeptidome focused on profiling MHC-I-associated peptides (MAPs) from canonical proteins in bulk tumor samples; however, non-malignant cell populations comprise most of the pancreatic tumor mass, obscuring the identity of MAPs that derive …
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Advancing T Cell–Based Immunotherapies: Identification of Tumor-Specific T Cell Receptor Targets and Mechanisms of Resistance in Solid Tumors
… antigen presentation and potentially reshape the immunopeptidome, thereby increasing tumor immunogenicity.</p> <p>In summary, these efforts have not only expanded the repertoire of targetable antigens for T cell therapy but also uncovered novel immune regulators whose deletion enhances …
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Conserved Non-Pocket Interactions Drive The Diversity of Peptide Presentation By Mhc Class I Molecules
<p>Cytotoxic T-lymphocytes (CTL) can lyse infected or transformed cells through recognition of peptides presented on human leukocyte antigen (HLA) molecules. A thorough understanding of peptide-HLA interactions is needed for improvement of CTL-based immunotherapies. We observed that aspartic acid …