Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"immunomodulatory genes"”.
-
Evolutionary History of Immunomodulatory Genes of Giant Viruses
… have 135-360 kbp genomes with about half of the genes encoding essential replication genes and the other half encoding genes related to host-virus interactions. Many of the genes involved in host-virus interactions are involved in immunomodulatory processes and have homology to proteins encoded …
-
Development, characterization and transcriptional profiling of a mouse model of fatal infectious diarrhea and colitis
… FVB mice, and expression of pro-inflammatory and immunomodulatory genes in the colon was similar in both lines of mice, suggesting that mortality in C. rodentiuminfected FVB mice is due to hypovolemia resulting from severe dehydration. To identify host factors responsible for the development of …
-
Cross talk between the glucocorticoid receptor and the progesterone receptor in modulation of progestin responses and HIV-1 infection
… are both transcription factors and regulate genes involved in immune function. Both the GR and PR are expressed in the cervix, the primary site of heterosexual HIV-1 infection. PR is regulated by endogenous estrogen (E2), of which the concentrations fluctuate throughout the menstrual cycle, …
-
Structural Mechanism of Orthopoxvirus Sabotage of MHCI Antigen Presentation
<p>Immunomodulatory proteins that subvert major histocompatibility complex class I: MHCI) antigen presentation can help viruses to evade cytotoxic T-lymphocyte: CTL) detection and clearance. Cowpox virus, like other orthopoxvirus family members, is a large DNA virus, whose genomic termini encode …
-
Antiretroviral drugs differentially modulate glucocorticoid activity via the glucocorticoid receptor in vitro
… altered the effects of (100 nM) DEX on the immunomodulatory genes assessed in PBMCs. DEX, MPA and LNG (at 100 nM) did not affect the anti-HIV-1 activity of the ARVs (at 1 µM) in PBMCs from the majority of the three donors tested in this study. Taken together, the results show that ARVs can …
-
Hypoxic immunomodulation results in increased disease risk and altered behavior via non-canonical pathways
Hypoxia is a potent immunomodulatory condition that underlies a wide array of disease states and associated comorbidities. Inflammation appears to be a critical factor in the adverse psychological outcomes linked with hypoxia/reoxygenation injury. A causative role for brain-based IL-1 has been …