Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"immunomodulators"”.
-
Cytokine-bearing Influenza Vaccine: Adjuvant Potential of Membrane-bound Immunomodulators
Influenza epidemics continue to cause morbidity and mortality within the human population despite widespread vaccination efforts. This, along with the ominous threat of an avian influenza pandemic (H5N1), demonstrates the need for a much improved, more sophisticated influenza vaccine. Our group has …
-
Synthesis and evaluation of CYP27A1 inhibitors and NR0B2 agonists as anticancer immunomodulators
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
-
Membrane-Bound Immunomodulators As Adjuvants In A Cell Culture-Based Avian Influenza Vaccine
<p>Inactivated viral vaccines often generate suboptimal immune responses. Adjuvants are incorporated into vaccines to increase their immunogenicity, however currently available adjuvants have shortcomings which have limited their use in human and veterinary medicine. This necessitates the …
-
The Synthesis of Glucosamine-Based Derivatives with Potential as Immunomodulators, Kinase Inhibitors, and Prodrugs
Chapter 1 gives a brief outline of the relevance of carbohydrates in biological systems. Special attention has been given to the roles of glucosamine and N-acetyl glucosamine. Chapter 2 details the synthesis of novel glucosamine-based serine glycolipids, which were tested for their immunomodulatory …
-
The damaged mucosal barrier in intestinal inflammation: interaction with therapeutic bacteria and roles for metallothioneins as immunomodulators
… part, the role of metallothioneins (MTs) as immunomodulators in intestinal inflammation is investigated. We found a significantly lower mRNA and protein expression in the epithelium of unaffected tissue of Crohn’s disease patients. In vitro studies with an MT-knockdown intestinal epithelial …
-
Enhancement of HIV vaccine efficacy via lipid nanoparticle-based adjuvants
Adjuvants are immunomodulators and/or formulations/delivery vehicles which enhance immune responses to vaccines. The lack of progress in the development of an HIV humoral vaccine is due, in part, to the absence of available adjuvants which can be sufficiently potent with minimal adverse side …
-
The Synthesis of Amphiphilic Glycolipids as Potential Inhibitors of Bacterial Adhesion
… they can be utilised as anti-adhesion agents and immunomodulators. The concept of multivalency is also discussed, with specific examples relating to the anti-adhesion approach. A variety of O-glycolipids based around an aspartic acid scaffold were constructed in chapter 2. Based on a modular …
-
Biomarkers and cell phenotypes in TB patients with minimal or persisting lung inflammation post-anti-TB treatment and ex-vivo atorvastatin immunomodulatory effects on M. tuberculosis-infected PBMC
… for their pleiotropic effects, show potential as immunomodulators to reduce post-TB lung inflammation. The ongoing StatinTB clinical trial utilizes a double-blind, randomized, placebo-controlled approach post-anti-TB treatment to assess the safety and efficacy of atorvastatin in reducing post TB …
-
Predicting poor outcome Crohn's disease at the time of first diagnosis
… surgery. Early and aggressive drug therapy with immunomodulators (IMMs) and biologics may alter the likelihood of these complications and improve long-term outcomes. However, this approach is extremely expensive and carries its own battery of side-effects such as infections and malignancy. In …
-
Arming adoptively transferred T-cells with drug-loaded nanoparticles for cancer immunotherapy
… such as interleukins, chemotherapy, and other immunomodulators, but these adjuvant treatments are often accompanied by serious toxicities and may still fail to optimally stimulate lymphocytes in all tumor and lymphoid compartments. Here we propose a two-pronged approach to address this problem, …
-
A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
… cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. ER export was facilitated by …
-
The effects of dietary β-glucan supplementation on performance and immune response of broiler chicks during an Eimeria challenge
… receiving increased attention is the use of immunomodulators such as β-glucan. A pilot study evaluated the effects of a yeast derived β-glucan (Auxoferm YGT) on growth performance and immune response of broiler chickens. Day-old chicks were fed a diet containing 0, 0.02, or 0.1% yeast …
-
Design of Novel Antigen-Specific Immunotherapies for the Treatment of Autoimmune Disorders
… autoimmune disorders, such as corticosteroids or immunomodulators, generally focus on symptom suppression or slowing disease progression rather than treating the underlying cause, which is rarely fully understood. New approaches to treatments in which a disease-causing autoantigen is known seek to …
-
Synthetic Alkyl Glycolipids as Therapeutic Agents: Their Synthesis as Potential iNKT Cell Stimulators and their Anti- Microbial Properties
… 4 to probe their potential application as immunomodulators. Focus was applied to the synthesis of a suitable building block which could provide access to a range of different analogues, possessing α- and β- glycosidic linkages. A short chain α-analogue of KRN7000 was successfully …
-
Rožinės sukelti akių pažeidimai: paplitimo, būdingiausių simptomų ir gydymo analizė /
… factors (58.8 %), the least common – topical immunomodulators (26.5 %). According to the respondents, the complete disappearance of eye symptoms was mostly achieved by using topical antibiotics – symptoms disappeared in 20.6 % of the respondents. The least effective measure, which did not help …
-
Exploring antiviral strategies: From innate immunity modulation to viral proteins targeting
… selectively, iii) study the effect of immunomodulators with unknown targets in order to identify potential broad-spectrum antiviral. Among the cellular proteins possibly used as drug target, a recently discovered one is STING: a downstream actor in the detection of non-self cytosolic …
-
A Radical Approach to Syntheses and Mechanisms
… anti-virals, anti-inflammatories, and immunomodulators. To establish synthetic feasibility of intramolecular homolytic substitution at selenium for preparation of selenocycles, we set out to determine what factors influence cyclization kinetics. A series of photochemically labile Barton …
-
Dissecting Drivers of Basal Immunity and Acute Responses to Viral Infection
… was observed for growth factors, chemokines, immunomodulators, and proinflammatory cytokines. Additionally, compared to Nicaraguans, Memphians exhibit higher activated myeloid and lymphoid subsets, and have CD8 T cell receptor repertoires which are significantly more clonal and less diverse. …
-
Topical pharmacokinetics for a rational and effective topical drug development process
… antifungals, antibacterials for acne and immunomodulators. For seven out of the eight classes, the validation of the model is good. For the last class, the antibacterials for acne, the model underpredicts efficacy and it is suggested that the route of entry of antibacterial agents in acne …
Page 1 of 2