Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"immunomodulating"”.
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A Retrospective Review of Paediatric Non-Infectious Uveitisin Cape Town: Disease Characteristics and Outcomes on Immunomodulating Treatment
Background Uveitis is a known cause of blindness in the developed world, where non-infectious diseases dominate the spectrum of underlying aetiologies. However, data from sub-Saharan Africa is lacking. Here we aim to describe the diseases associated with non-infectious uveitis and the impact of …
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Interactions of entomopathogenic fungi and other control agents: mechanism and field potential against Hylobius abietis larvae
… Hylobius abietis, to screen for species with immunomodulating properties. The potential of the commonly used model organism, the greater wax moth, Galleria mellonella, as a model for the study of the immune response of H. abietis to pathogens was also explored. Hylobius abietis, the large pine …
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Renal Toxicity Warnings and Precautions of Drugs Marketed in the US
… for systemic use, antineoplastic and immunomodulating agents, and alimentary tract and metabolism. The most common boxed warnings were renal impairment, nephrotoxicity, and nephrogenic systemic fibrosis, with some warnings referring to potential problems for patients with kidney …
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Cellular and Molecular Aspects Of Naïve T cell Priming for Adoptive Immunotherapy
… Blockade has led to the rapid approval of immunomodulating drugs for the treatment of metastatic cancers. However, despite recent success, a large proportion of patients do not respond or only experience a partial response. Now, it is becoming increasingly evident that the effectiveness of …
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The effects of nitrosoureas on Thymocyte differentiation and T cell activation
… the efficacy of nitrosoureas may depend on their immunomodulating properties. In the current study, therefore, attempts were made to investigate the effects of these nitrosoureas on the immune system of normal and LSA tumor-bearing mice. Treatment of normal C57BL/6 mice with 5 intraperitoneal …
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Using Saccharomyces cerevisiae to characterise the in vivo effects of exposure to the prion-curing drug Tacrine and the fungal metabolite gliotoxin
… has demonstrated that gliotoxin displays immunomodulating capacity and anti-viral activity, and induces apoptosis and necrosis. The gli gene cluster responsible for gliotoxin biosynthesis has recently been identified and is continually being further characterised. In this study, evidence …
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Effects of pelvic 3D-CRT versus IMRT radiation therapy on circulating pro-inflammatory cytokines in high risk Prostate Cancer patients
… in IL-4 and INF-γ over time suggest a potential immunomodulating effect of radiation therapy. Further studies are needed to determine the potential of cPIC as biomarkers of radiation therapy toxicity.
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Authorizations, Prices, and Labeling Differences of Therapeutic Biologics Marketed in the United States and Saudi Arabia
… in the therapeutic classes of antineoplastic and immunomodulating agents and blood and blood-forming organs were found to be statistically associated with availability in Saudi Arabia (p</p>
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Effect of Lactoferrin to Increase Drug Permeability of Primary Pulmonary Mycobacterial Granulomas
… of granulomas using lactoferrin, an immunomodulating agent, it will allow greater penetration of therapeutics into the site of focal inflammation. Our lab has reported that oral bovine lactoferrin treatments during the innate immune response leads to significant modulation of the …
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HOST DEFENSE PEPTIDES OF THE COAGULATION SYSTEM AND THEIR THERAPEUTIC POTENTIAL
… length- and sequence-dependent antimicrobial and immunomodulating effects in vitro and in vivo as illustrated by increasing survival rates in mouse models of LPS-induced septic shock (paper I). Quantitative structure-activity relationship (QSAR) analysis utilizing biophysical, antimicrobial and …
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Development of Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spns2 for the Treatment of Multiple Sclerosis
… is of particular interest for the development of immunomodulating agents. To reach its native GPCRs, S1P must be released from the cell. This process is facilitated by the transmembrane transport protein Spinster homolog 2 (Spns2) in most vertebrates. Studies in murine species have demonstrated …
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CROSSTALK BETWEEN GLIOMA CELLS AND TUMOR ASSOCIATED-MACROPHAGES: MECHANISMS AND THERAPEUTIC STRATEGIES
… tumor progression and the resistance to immunomodulating treatments. Mutations in enzymes isocitrate dehydrogenases (IDH) occur in GBM subsets, characterized by more favorable prognosis. Also, other molecular alterations and metabolic features, such as accumulation of the oncometabolite …
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Antifungal Immune Responses and Inflammation in the Cystic Fibrosis Airways
… strongly suggests that Kaftrio has an additional immunomodulating effect without compromising antifungal activity. I explored if FRISA (Fungal Ribosomal Intergenic Spacer Analysis) could be a valuable and easy to perform technique to study the mycobiome in clinical samples. Unfortunately, due to …
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Antifungal Immune Responses and Inflammation in the Cystic Fibrosis Airways
… strongly suggests that Kaftrio has an additional immunomodulating effect without compromising antifungal activity. I explored if FRISA (Fungal Ribosomal Intergenic Spacer Analysis) could be a valuable and easy to perform technique to study the mycobiome in clinical samples. Unfortunately, due to …
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A retrospective data analysis in veterans with inflammatory bowel disease: Using Wagner's Chronic Care Model to explore medication adherence
… the following factors: taking both a 5-ASA and immunomodulating medication (OR=5.122,95%CI=1.874-14.00, p=.001), younger age (OR=.905,95%CI=.871-.940,p=.001), and having a comorbidity (OR=2.643,95%=1.171-5.965,p=.027). </p><p> Conclusions </p><p> No predictors of medication adherence emerged. …
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Lipid antigens and immunoregulatory iNKT cells in the prevention and treatment of type 1 diabetes and related autoimmune diseases
… could be introduced in order to exploit immunomodulating potential, and find a possible prophylactic therapy for the prevention and treatment of autoimmune diseases, such as T1D.
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Immunological Mechanisms of Extracorporeal Photopheresis In Cutaneous T Cell Lymphoma and Graft Versus Host Disease
… photopheresis (ECP) is an effective, low-risk immunomodulating therapy for leukemic cutaneous T cell lymphoma (L-CTCL) and graft versus host disease (GVHD), but whether the mechanism(s) of action in these two diseases is (are) identical or different is unclear. To determine the effects of ECP …
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Molecular mechanisms of TOM1-mediated protein trafficking in health and disease
… help identify new targets for drug therapies and immunomodulating treatments. The first mechanism explored is brought about by the invasion of host cells by Shigella flexneri. S. flexneri injects the virulence factor IpgD, which converts phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] to …
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Large-scale studies and biophysical analysis of systems involved in plant immunity.
The field of plant immunity has progressed significantly in the last decade, driven primarily by both forward and reverse genetics and to a lesser extent by molecular biology techniques. However, many unknowns still remain before a more complete picture of this system can be achieved, which hinders …