Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"immunometabolism"”.
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Delineating The Immunometabolism Of Human Invariant Natural Killer T Cells
… of this thesis work was to characterize the immunometabolism of iNKT cells and investigated whether this differs from TCONV. Using transcriptional profiling, nutrient depletion studies, flow-based metabolic dyes, and Seahorse flux metabolic assays to measure real-time activity, we discover …
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Molecular regulation of nutrient sensing and immunometabolism by calorie restriction
“‘You'll live longer and you'll be healthier too,’ he answered. ‘Because as we were saying today, there's nothing in the world like eating moderately to live a long life.’ ‘If that's the way things are,’ I thought to myself, ‘I never will die.’ Because I've always been forced to keep that rule, and …
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The Formyl Peptide Receptor 2 Regulates Microglial Phenotype Through Immunometabolism: Implications for Alzheimer’s Disease
Microglia are key players in the pathology of Alzheimer’s disease (AD), driving chronic inflammation, oxidative stress, and the altered metabolism seen in the brains of patients. With clinical trials continuing to fail, new approaches towards drug development are critical. Strategies to reduce …
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Modulating Immunometabolism to Improve The Activity of Car-Nk Cells Targeting Cd70 In Renal Cell Carcinoma
<p>Despite the approval of several therapies for metastatic clear cell renal cell carcinoma (ccRCC), disease resistance and relapse are common, and therapies with novel mechanisms of action are urgently needed. Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable responses in …
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Immunometabolism of methyl donors by dairy cattle during periods of negative nutrient balance and heat stress
… (NNB), decreased milk production and altered immunometabolism. The first experiment examined the effects of post-ruminal choline supply during NNB on production and pathways of one-carbon metabolism. Ten primiparous rumen-cannulated cows (158 ± 24 DIM) were used in a replicated 5 5 Latin …
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Characterisation of Mucosal Associated Invariant T cells function and metabolism in health and obesity
… which leads to their dysfunction in obesity. Immunometabolism of MAIT cells became the focus of this thesis as previous data indicated it as a key biological process that controls immune cell function. Here we confirmed previously published data, showing that MAIT cells are potent producers of …
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Mitochondrial regulation of CD8+ T cell cytotoxicity
Recent discoveries in the field of immunometabolism have emphasised the importance of mitochondria in the context of T cell development, differentiation, signalling and exhaustion. However, the question of whether mitochondria can actively participate to the killing activity of differentiated, …
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Investigating The Metabolic Progression of Glioblastoma With Hyperpolarized Magnetic Resonance
… NMR spectroscopy is presented in the context of immunometabolism. Specifically, metabolic events associated with the licensing process of natural killer cells as well as macrophage polarization are analyzed. Collectively, this work demonstrates the value of interrogating the metabolism of GBM and …
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Microglial succinate receptor 1 (SUCNR1) sustains chronic CNS inflammation
The rapidly evolving field of immunometabolism has shed new light on new fundamental properties of metabolites, which can regulate inflammation via ligand-receptor signalling modalities. Among these, succinate signalling via succinate receptor 1 (SUCNR1) plays a key role in controlling myeloid …
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DEPDC5 is a metabolic checkpoint regulator in the B cell AA-mTORC1 pathway
Immunometabolism is a rapidly developing field that is central to understanding the homeostatic maintenance and induction of immune responses. Naïve B cells rest in quiescent states until antigen (Ag) is encountered, which simultaneously triggers a metabolic switch enabling enhanced growth, …
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Clusterin: A Regulator of Glial Biology and Alzheimer’s Disease Pathogenesis
… Moreover, a role of CLU in modulating astrocytic immunometabolism is supported since loss of CLU reduced ATP-induced intracellular calcium (Ca2+) response and the activity of a hydrolase enzyme, β-galactosidase. In chapter 4, the role of CLU in AD pathogenesis was investigated using an AD mouse …
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Using prophylactics to improve resistance against Enterobacteriaceae in chickens
… SPORE treatment induced drastic shifts in host immunometabolism. Furthermore, these changes were associated with Salmonella resistance, as TH17 cell differentiation was positively associated with in vitro killing of several Salmonella serovars. Overall, we find that a single dose of an ileal …
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Ubiquitination of proteins involved in metabolism and immunomodulatory drug sensitivity in lymphocytes
Proteins undergo post-translational modifications, such as ubiquitination and phosphorylation, which can alter their activity, localisation and stability, making a cell responsive to its internal and external environment. Ubiquitin ligases and kinases comprise large enzyme families which catalyse …
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A comparative evaluation of the gastrointestinal immune response of the modern and heritage broiler chicken
The modern broiler chicken is the result of 60 years of selective breeding for rapid rates of growth and muscle deposition. These birds are highly efficient, require relatively small quantities of feed, and are ready for market in as little as six weeks. However, selecting for the rapid growth …
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Activation and Maintenance of Intestinal Intraepithelial Lymphocytes (IELs)
The intestinal tissue is charged with a delicate immunological task. The intestinal immune system needs to be tolerant towards nutrients and microbiota present in the intestinal lumen, while simultaneously detecting and responding to dangers such as pathogens. A single-cell layer of intestinal …
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KUPFFER CELLS¿ MITOCHONDRIAL PLASTICITY AFFECTS SYSTEMIC IMMUNO-METABOLISM
BACKGROUND: Kupffer cells (KCs) are hepatic resident macrophages that are essential for liver physiology and contribute to the development of metabolic-associated fatty liver disease (MAFLD). Due to their high plasticity, KCs can maintain immunotolerance and mediate cell-cell interaction within the …
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Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
Certain lactic acid bacteria (LAB), such as Lacticaseibacillus rhamnosus R0011, are associated with immune modulatory activities including down-regulation of pro-inflammatory gene transcription and expression. While host intestinal epithelial cells (IECs) and antigen-presenting cells (APCs) can …
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Role of exercise-sensitive microbial-derived aromatic amino acid metabolites in modifying monocyte physiology
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Characterising the immunometabolic profile of HIV/TB co-infection
The synergy between the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) during co-infection of a host is well established. While this synergy is driven by immunological deterioration, the metabolic mechanisms that contribute to the …
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