Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"immunological synapse"”.
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Immunological synapse arrays : patterned protein surfaces that modulate immunological synapse structure formation in T cells
… at the T cell-APC interface known as the immunological synapse (IS). It remains unresolved whether the unique physical structure of the synapse itself impacts the functional response of T cells, independent of the quantity and quality of ligands encountered by the T cell. As a first step …
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Opposing Actin Networks Modulate the Mechano-Activation of the Integrin LFA-1 During Immunological Synapse formation
… regulated area of cell - cell contact termed the immunological synapse (IS). In T cells responding to APCs there is a robust accumulation of F-actin on the T cell side of the synapse. This F-actin response is characterized by robust polymerization at the periphery of the contact site followed by …
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Cytokine-capture nanoparticles to quantify IL-2 concentrations within the immunological synapse during T cell activation
The feasibility of bringing a nascent technology for detection and quantification of local cytokine concentrations on cell surfaces to market is presented in this paper. Quantum dots or fluorochrome-loaded nanoparticles are conjugated with antibodies for target analytes and with proteins that allow …
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Biological effects of trogocytosis on CD4+ T lymphocytes
… temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological synapse. The mechanism and biological significance of this process, termed …
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Biological effects of trogocytosis on CD4+ T lymphocytes
… temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological synapse. The mechanism and biological significance of this process, termed …
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pH-sensitive resist materials for combined photolithographic patterning of proteins and fluid lipid bilayers
… T cell and antigen- presenting cell at the immunological synapse.
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Design of Novel Antigen-Specific Immunotherapies for the Treatment of Autoimmune Disorders
… focus on disrupting immune recognition at the immunological synapse by conjugating autoantigen on a multivalent polymer support. Polymer-drug conjugates also present a unique opportunity as a depot delivery system with the potential for targeted applications. The strategies presented here carry …
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Molecular mechanisms and complete antigen formation in allergic contact dermatitis
… of the H2-Aq/antigen/TCR complex, a part of the ”immunological synapse”. Our new model could explain the experimental T cell responses in terms of a defined structure of the MHC/antigen, and how this structure is displayed for the TCR. This study may contribute to better diagnosis, and possibly a …
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S-Acylation Is A Key Regulator of Orai1/Stim1-Mediated Store-Operated Calcium Entry In T Cells
… it to bind Orai1 at ER-PM junctions within the immunological synapse. Binding of STIM1 to Orai1 activates the CRAC channel resulting in SOCE. Although the functional importance of these events is well-known, the molecular mechanism supporting timely and efficient recruitment of both Orai1 and …
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Dissecting the interplay between cytotoxic T lymphocytes and the pancreatic cancer stroma
… cells by directing cytotoxic granules toward the immunological synapse formed with their target. Although CTL infiltration into solid tumours often correlates with improved patient outcomes, the mechanisms by which CTLs are recruited within tumour sites remain only partially understood. Moreover, …
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PIP5-Kinase Dependent PIP2 Generation Impairs T Cell Activation by Rigidifying the Actin Cortex
… cells (APCs). A specialized junction, the immunological synapse (IS), is formed at the T cell-APC interface, where cell surface receptors, signaling molecules as well as cytoskeletal elements rearrange into a highly organized structure (Monks et al., 1998; Grakoui et al., 1999; Cemerski et …
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Biomechanical regulation of T cells: The cytoskeleton at the nexus of force and function
… targets via a specialized interface called the immunological synapse (IS), where they release lytic granules containing cytotoxic molecules and exert cytoskeletal forces to induce target cell death. A key event in IS formation is polarization of the centrosome, or the microtubule-organizing …
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Study of Regulated Cell Death In Two Systems: Pd-1 In Natural Killer Cells and Rip3 In Neurons
… as NK cells that expressed PD-1 formed stable immunological synapse (IS) with target cells that expressed the PD-1 ligand, PD-L1. Instead, the PD-1 engagement by PD-L1 blocked lytic granule (LG) polarization <em>via</em> disruption of the integrin ‘outside-in’ signaling pathway and abolished …
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Investigation of T cell signalling events regulating immunity and tolerance in vivo
… Rap1 may be up-regulated and recruited to the immunological synapse upon re-stimulation with Ag in anergic T cells and that such Rap1 localisation and expression may contribute to the downregulation of ERK recruitment and activation in these cells. It is important to note that this inverse …
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Alterations in lymphocyte signalling produced by exposure to mercury
The effects of 1 min – 4 hr exposures to mercuric chloride (HgCl2), methyl mercuric chloride (CH3HgCl), p-chloromercuribenzoate (p-CMB) and ethylmercurithiosalicylate (TMS) on cell viability and kinetics of cell death, microtubules, F-actin, CD3 receptor expression, protein tyrosine phosphorylation …