Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"immunological memory"”.
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Vaccination and immunological memory
Human subjects maintain long-term immunological memory against infective organisms but the mechanism is unclear. CD4+ T helper memory cells (Thmem) are pivotal in controlling humoral and cellular responses, therefore their longevity and response to vaccination are critical for maintenance of …
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On Immunological Imprinting
Immunological memory is considered the hallmark of the adaptive immune system, where primary exposure to an antigen establishes a population of memory cells capable of responding to future encounters to the same antigen with increased speed and magnitude. For rapidly mutating respiratory pathogens …
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Mathematical modeling of infectious disease
… An outstanding feature of this defense is immunological memory. Immunological memory can develop after infection or vaccination, and provides increased protection to secondary challenge. The cells contributing to memory can be identified phenotypically by protein markers, or kinetically as …
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Technical, economic, and clinical challenges to the development of new biomaterials-based vaccines
… infected or cells in the body and/or develop immunological memory for future protection against the disease. The purpose of this paper is to analyze the feasibility of getting such a biomaterials-based novel vaccination method to the market. Topics such as application potential, efficacy, …
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Coordinated Blockade of TGF-β and PD-L1 Promotes Anti-Tumor Immunity in Ovarian Cancer Models
… skewing of macrophages, NK cells, and T effector memory cells, corresponding with long-term immunological memory responses. BA treatments enhanced cytotoxicity that was traced back to resident memory T cells and decreased suppressive Gata6+ large peritoneal macrophages in the tumor, thus reshaping …
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HMGB1- An Immunotherapeutic Target for the Treatment of Neonatal Sepsis and Associated Neuroinflammation
… Tissues taken from sepsis survivors displayed immunological memory; protective effects of treatment with pAb α-HMGB1 pAb antibodies was observed both shortly after sepsis recovery and within microglia/macrophage cells during adulthood. Evaluation of behavioural deficits in adulthood displayed …
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Engineering immunity : enhancing T Cell vaccines and combination immunotherapies for the treatment of cancer
… durable cures in a majority of animals, formed immunological memory in multiple transplanted tumor models, and induced sustained tumor regression in an autochthonous BRraf[superscript V600E]/Pten[superscript -/-] melanoma model. Finally, in Chapter 5, we show preliminary data on combination …
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Integrin-targeted cancer immunotherapy
… including durable cures and development of immunological memory. Contrary to prior attempts at integrin-targeting, the mechanism of action was independent of functional integrin antagonism, including effects on angiogenesis and tumor proliferation. In fact, efficacy of this therapy depended …
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Attenuation of Interferon Responses in the Obese Host and Ramifications for Influenza Virus Evolution
… virus infection, poor recovery, and impaired immunological memory. However, the majority of past work neglected the innate responses, especially the impact on the epithelium. To better understand the innate response to influenza infection, obese animal models and human respiratory epithelial …
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Memory Potential, Molecular Characterization, and Translational Applications of The Novel Theo/Tceo T Cell Phenotype
… of T cell-mediated immunity is formation of immunological memory; the ability to respond more potently to re-encounter with pathogens. The immune system is also capable of recognizing tumors as foreign, much like viral or bacterial pathogens. Tumors have evolved, though, to generate an …
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The development of a process and quality control methods for conjugate vaccine against streptococcus pneumoniae serotype 1
… vaccines are effective in young children, induce immunological memory and reduce carriage. A conjugate vaccine against 7 serotypes (PCV7) was licensed in 2000 which resulted in a dramatic reduction of IPD. An increase in the number of cases due to non–vaccine serotypes (serotype replacement) led …
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Improving methods for cytokine immunotherapy of cancer
… increased long-term survival and generated immunological memory. Successful combination therapy required IFNa-induced activation of cross-presenting CD8[alpha]+ DCs following release of antigenic tumor debris by the IL-2-and-antibody-mediated immune response. Due to decreased phagocytic …
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Collagen Anchoring Agonist Antibodies for Cancer Immunotherapy
… cure rates while additionally generating robust immunological memory. Together, my thesis work demonstrates that collagen anchoring is an effective strategy to improve the therapeutic index of agonist antibody therapies and furthermore uncovers a fundamental two-step approach to designing …
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Generation of Memory of Infection During the CRISPR-Cas9 Immune Response
… function of Cas9 in the genesis of prokaryotic immunological memory. To further explore the link between Cas9 and spacer acquisition, I performed random mutagenesis of the RNA-guided Cas9 nuclease to look for variants that provide enhanced immunity against viral infection. I identified a …
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Follicular Regulatory T cell migration and differentiation
… highly effective humoral immune responses and immunological memory that forms the basis of successful immunisation. Control of the output of the GC response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells located within germinal centres. Tfr cells were first …
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The Immunology of Adeno-Associated Virus Serotype 2
… immunodominant. These data indicate that robust immunological memory is established to AAV-2. The diversity of sequences recognised suggests that attempts to modify the AAV-2 capsid, as a strategy to avoid confounding immunity, will not be feasible. It was hoped that murine mesenchymal stem cells …
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An investigation towards a conjugate vaccine against Streptococcus pneumoniae serotype 19A
… young children against disease by inducing immunological memory and reducing carriage of the bacteria. A pneumococcal conjugate vaccine against seven serotypes (PCV7) was licensed in 2000, which resulted in a dramatic reduction of IPD. However; there was a gradual increase in the number of …
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Genetics, humoral immunoresponsiveness, and disease resistance in chickens
… immunocompetence was evaluated by primary, memory, and maternal antibody responses to SRBC. Primary antibody response, measured 5, 10, and 20 days after inoculation with SRBC was greater in HA than LA chicks inoculated at 14, 21, and 28 days of age. In chicks injected at 7 days of age, a …
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Accessory Nucleases Provide Robust Antiparasite Immunity for Type III CRISPR-Cas Systems
… a parasite into its CRISPR locus as a form of immunological memory. Upon reinfection, short RNAs transcribed from the CRISPR locus can guide Cas proteins to the viral genome through complementary base pairing. Cas nucleases then destroy the invader's genome. To date, six major types and …
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Regulation and Effector Function of TH1 and TH2 Cells in Immunity to Bordetella Pertussis
… antibody response post-challenge suggest that immunological memory is more significant in protection, than the induction of immediate antibody responses in vaccine-induced protection against B. pertussis. It has been demonstrated that Thl responses and particularly the cytokine IFN-y, play a …
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