Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"immunologic memory"”.
-
Immunologic Memory to Polysaccharide Antigens
<p>Immunologic memory is the ability of the immune system to generate an enhanced antibody response against previously encountered antigens. The clonal selection theory of acquired immunity attributes immunologic memory to the formation of an expanded compartment of quiescent antigen-specific …
-
Stimulation of chemotherapy-induced immunity by targeting IL-6 in the tumor microenvironment
… that culminate in the generation of long-term immunologic memory. These findings reveal one of the mechanisms by which microenvironmental changes brought upon by tumor cells result in therapy resistance and disease recurrence. Therefore, we present supporting evidence that unravelling the …
-
Development and Characterization of B7-H3-Targeted Radioimmunotherapies For The Treatment of Solid Tumors
… <sup>90</sup>Y-DOTA-MIL33B treatment developed immunologic memory and <em>in vivo </em>depletion assays demonstrated that CD8b+ cells were necessary to confer the therapeutic effects of <sup>90</sup>Y-DOTA-MIL33B. These results point to the promise of <sup>90</sup>Y-DOTA-MIL33B …
-
Cas9-Primed Adaptive Immunity During the CRISPR-Cas Response
… DNA or RNA. Thus, spacers function as a form of immunologic memory that can be called upon again and again to defend the cell from reinfection. In type II CRISPR-Cas systems, spacer sequences direct the Cas9 nuclease to target infecting bacteriophages and cleave their double-stranded (ds)DNA …
-
Regulation of Effector and Memory Development of Human CD4+ T Cells by Interleukin 12 and Type I Interferon
… CD4+ T cell development, effector functions, and memory generation. Previous reports had suggested that IFN-alpha, like IL-12, could promote Th1 development in human CD4+ T cells. However, my work demonstrates that IFN-alpha is insufficient to induce Th1 differentiation because of an inability to …
-
Reciprocal Regulation of CD4+ and CD8+ T Lymphocyte Effector and Memory Fates by Interleukin 12 and Type 1 Interferon
… and IFN-a/b on the development of effector and memory responses in human CD4+ and CD8+ T cells. My work has found that IL-12 drives the development of effector CD4+ and CD8+ T cells. In contrast, IFN-a/b was incapable of promoting these responses and this was due to a difference in the kinetics …