Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"immunoglobulin-like"”.
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Structural and molecular studies of group II leukocyte immunoglobulin-like receptors.
The Leukocyte Immunoglobulin-Like Receptors (LILRs) are a family of immunomodulatory transmembrane receptors with both activatory and inhibitory forms, and are primarily expressed on myelomonocytic cells. Group I LILRs include the well-characterised members LILRB1 and LILRB2, which bind MHC Class I …
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The pattern and functional consequence of Killer Immunoglobulin-like Receptor expression on T cells.
Killer immunoglobulin-like receptors (KIRs) are a family of proteins expressed on human natural killer cells and a subset of T cells. Several inhibitory KIRs have been shown to recognise MHC class I molecules (predominantly HLA-C), with their engagement preventing target cell lysis. The ligand(s) …
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Killer Cell Immunoglobulin-Like Receptors Delineate Distinct Phenotypes and Functions in Human γδ T Cells
… and function, with emphasis on Killer-cell Immunoglobulin-like Receptors (KIRs), which are poorly studied in the field of γδ T cell biology. Because cytomegalovirus (CMV) is known to shape the αβ T cell and NK cell repertoires, I studied peripheral blood (PB) γδ T cells from both …
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Genetic and functional characterisation of killer cell immunoglobulin like receptors (KIR) of rhesus macaques (Macaca mulatta)
… der genetischen Diversität der killer cell immunoglobulin like Rezeptoren (KIR) und die Interaktion zwischen KIR und MHC-Klasse-I Molekülen im Rhesusaffen (Macaca mulatta). In Menschen wurde gezeigt, dass KIR Haplotypen Auswirkungen auf die Resistenz gegen unterschiedliche Krankheiten haben. …
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Estradiol regulation of leucine-rich repeat immunoglobulin-like domains protein 1 (LRIG 1) and roles of estrogen receptor in translational regulation in breast cancer cells
… of several estradiol-regulated mRNAs. Unlike other ERα-interacting partners such as Jab1 and E6-AP, eIF3f interacts with a shorter form of ERα. The effects of estradiol on cellular function are pleiotropic. As a transcriptional regulator, ER regulates many genes that can have a subsequent …
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Structure of the Chicken Neuron-Glia Cell Adhesion Molecule, Ng-CAM: Origin of the Polypeptides and Relation to the Ig Superfamily
… amino acid sequence reveals the presence of immunoglobulin-like domains and fibronectin-type III repeats, and establishes the relationship of Ng-CAM to other neural CAMs containing similar structures. The thesis also describes the identification of a similar protein in the embryonic chicken …
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Computational Investigations of Cellular Functions: Three Cases on Membrane Morphogenesis, Organization and Assembly of a Multi-Protein Complex, and the Molecular Origin of Muscle Elasticity
… elasticity; secondary structures of titins immunoglobulin-like (Ig-) and fibronectin type III-like (FN-III) domains provide a stiff elasticity. We demonstrated that titin exhibits a third type of elasticity due to tertiary structure and involving domain-domain interaction and reorganization …
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Characterisation of TAPBPR in immune cells
… shape the MHC-I presented peptidome. However, unlike its homologue tapasin, TAPBPR catalyses peptide exchange independently of the PLC. It works closely with UDP-glucose: glycoprotein glucosyltransferase 1 (UGT1) to filter sub-optimally loaded MHC-I molecules before export to the cell surface. To …
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Estradiol Regulation of Leucine-Rich Repeat Immunoglobulinlike Domains Protein 1 (Lrig 1) and Roles of Estrogen Receptor in Translational Regulation in Breast Cancer Cells
… estradiol. We identify leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) as an estradiol-regulated gene. LRIG1 is a negative regulator of Receptor Tyrosine Kinase (RTK) signaling. Up-regulation of LRIG1 mRNA and protein is mediated by the estrogen receptor-alpha (ERalpha) and …
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TLR3 Signaling in Human BDCA-3 Dendritic Cells Results in the Formation of Several ILT3 and ILT4 Populations
… Stimulating BDCA-3 DCs with Poly I:C, a toll-like receptor (TLR) 3 agonist, resulted in the up-regulation of various canonical activation markers such as CD40, CD80, and CD86 as well as immunoglobulin-like transcript (ILT) 3 and 4 as measured by flow cytometry. ILTs are novel surface molecules …
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A License to Kill: Understanding Natural Killer Cell Licensing to Fight Cancer
… cells before and after inhibition by killer-cell immunoglobulin-like receptors (KIRs) and activation by the NKp46 natural cytotoxicity receptor, including several related to cellular metabolic pathways. We explored cellular metabolism in the two subsets and found that licensed NK cells are highly …
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An investigation of the regulation of Sialoadhesin ligands on CD4+ T cells and its potential significance in Systemic Lupus Erythematosus
… (Sn) is the prototype of Sialic acid binding Immunoglobulin-Like Lectins(SIGLECs). Sn is expressed on macrophages from metalophilic zone and subcapsular sinus in spleen and lymph nodes respectively. Under inflammatory conditions, Sn expression is upregulated on macrophages. Sn was recently …
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Fc Gamma Receptors Facilitate Antigenic Modulation of LILRB4 and Function as Predictive Biomarkers in Acute Monocytic Leukemia
… patients are diagnosed at an age when they are unlikely to survive first-line non-targeted cytotoxic chemotherapy as a bridge to hematopoietic stem cell transplant (HSCT). Even patients who achieve remission commonly relapse. This population of patients would greatly benefit from …
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Genetische Charakterisierung des "Leukocyte Receptor Complex" und Entwicklung einer Methode zum Nachweis seiner Produkte im Einzelzellmaßstab
… vorkommen. Hierbei handelt es sich um ‚immunoglobulin-like transcript′ -Gene (ILT) und ‚killer cell Ig-like receptor′-Gene (KIR). Die KIR- und ILT-Cluster werden von weiteren stammesgeschichtlich verwandten Genen unterbrochen und flankiert. Je nach Individuum können im LRC bis zu 31 …
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Molecular and Metabolic Regulation of Gastrointestinal Cancer Metastasis
… was found to interact with adhesion molecule immunoglobulin like domain 2 (AMIGO2), newly identified cancer cell surface NPTX1 receptor in an autocrine manner that leads to nuclear retention of hypoxia inducible factor 1a (HIF1a) via phosphorylation of serine 641 and serine 643 residues. The …
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Selezione e processazione di cellule Natural Killer da donatore aploidentico "KIR-ligand" incompatibile per l'immunoterapia adottiva di pazienti con Leucemia Acuta Mieloblastica ad alto rischio
… and inhibitory receptors, termed killer immunoglobulin-like receptors (KIRs). In haploidentical T-cell depleted transplantation the donor/recipient KIR mismatch significantly impacts on NK-mediated tumor cell killing, particularly in acute myeloid leukaemia (AML). Thirty-four high risk …
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Characterization of a murine activated lymphocyte antigen (MALA-2) : the murine homologue of human intercellular adhesion molecule 1 (ICAM-1)
… MALA-2 is a transmembrane glycoprotein with five immunoglobulin-like domains. It displays homology with the human intercellular adhesion molecule 1 (ICAM-1), as well as human ICAM-2, human ICAM-3, and murine ICAM-2. Screening of genomic libraries yielded a partial genomic clone (4.0 kb ), …
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Characterization of Differentiation and Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma
… proliferative, expressed CD45RA and killer-cell immunoglobulin-like receptors (KIRs), and exhibited a gene expression signature of T cell deletion. Surprisingly, ligation of BTLA by its cognate receptor, HVEM, enhanced the survival of CD8<sup>+</sup>BTLA<sup>+</sup> TIL by activating Akt/PKB. Our …
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Characterization of the Human Adenovirus 19a E3/49K Protein
… with R3 exhibiting a significant homology to immunoglobulin-like domains. This study shows that 49K is a highly glycosylated protein with an apparent molecular mass of 80-100 kDa. 12-13 out of 14 predicted N-glycosylation sites are utilized, and there is also evidence for O-glycosylation. 49K …
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