Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"immunogenic cell death"”.
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Induction of Immunogenic Cell Death via Nanoparticle-Mediated Dual Chemotherapy and Photothermal Therapy
… the patient’s immune system to attack cancer cells and, consequently, requires an environment conductive to a targeted immune response against the cancer cells. To achieve this aim, we developed two types of nanoparticles (NPs) for combinatory chemo-photothermal therapy (PTT) to induce …
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Mechanisms of Immunogenic Cell Death in Tumour Cells Infected with Oncolytic Vaccinia Virus
Oncolytic viruses (OVs) infect and kill cancer cells whilst generating anti-tumour immune responses. The anti-tumour effect of OVs is attributed to their ability to induce immunogenic cell death (ICD) during their infection of tumour cells. The mechanisms by which ICD occurs is not well defined and …
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DESIGNING ANTI-PDL1 ANTIBODY CONJUGATED POLYMERIC COACERVATES AS A NOVEL “NANO-IMMUNOTHERAPY” AGAINST HEPATOCELLULAR CARCINOMA
Hepatocellular Carcinoma (HCC) accounts for a majority of primary liver cancer cases and is among the deadliest cancers in the world. With a shift in major risk factors from chronic viral hepatitis infections to that of metabolic diseases causing HCC, the number of HCC-related cases and deaths is …
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ARMING STRATEGIES TO IMPROVE THE IMMUNOTHERAPEUTIC POTENTIAL OF ONCOLYTIC HERPESVIRUSES
… (OVs) to selectively target and destroy tumor cells while triggering robust antitumor immune responses offers a highly promising avenue in cancer immunotherapy. Inside the wide viral repertoire for oncolytic virotherapy, Herpes simplex virus type 1 (HSV-1) stands out, due to its clinically …
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Preclinical Evaluation of Immunomodulatory Effects of Aurora Kinase Inhibition In Human Papillomavirus Positive Cancers
… apoptosis in HPV+, but not HPV- human tumor cells in vitro and in vivo in HPV+ patient derived xenografts (PDX) mouse models. We hypothesized that Aurora kinase inhibition mediated HPV+ cancer cell apoptosis would lead to immunogenic cell death (ICD) that would promote antitumor efficacy of …
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Chemotherapy-Eluting Intraperitoneal Implants for Advanced Stage Ovarian Cancer Treatment
… cisplatin release and for bioactivity against OC cell lines. Three-dimensional implant geometries were designed and prototyped to facilitate deployment by minimally invasive laparoscopic surgery. Sustained low-dose chemotherapy may also potentiate tumor antigen-specific immune responses, but the …
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Combination of Oncolytic Adenoviruses, T-Cell Activation, and Blockade of Ido Metabolic Circuitry For The Treatment of Glioma
… adenovirus, Delta-24-RGD, which elicits cancer cell lysis and immunogenic cell death. In fact, Delta-24-RGD produced complete responses in 20% of recurrent glioblastoma patients through immune mechanisms that activate anti-tumor cytotoxic properties of T-cells. This cytolytic effect can further …
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Investigating couplet strategies incorporating 4 pillars of cancer therapy
… can selectively induce apoptosis in cancerous cells by leveraging the overexpression of procaspase-3. Exploiting procaspase-3 overexpression by cancer cells is thought to explain why PAC-1 can synergize with chemotherapeutics, which has been demonstrated in several prior original research …