Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 44 for “"immunodominant"”.
-
Characterization of the Staphylococcus aureus Immunodominant Surface Antigen B, IsaB
… aureus disease. Lorenz et al first described the Immunodominant Surface Antigen B, IsaB, because it was 1 of 4 unique proteins immunogenic during septicemia and not colonization, suggesting that IsaB may be a virulence factor and a possible novel therapeutic target. Interestingly, IsaB has no …
-
Identification and Knockout of Immunodominant Endogenous Retroviral Antigen in Murine Tumor Models
Advances in cancer immunotherapy have demonstrated the dominant role of T cells in an anti-tumor response, but the functional role of B cells and their antibodies in cancer remains less clear. In murine tumor models, curative immunotherapies have been previously shown to result in the development …
-
Computational Study of Vaccination Strategies to Change B Cell Immunodominance
… and SARS-CoV-2 which rapidly modify the immunodominant epitopes and render existing antibodies ineffective. Moreover, as the immune system preferentially targets immunodominant epitopes, functionally important and conserved epitopes are less targeted, which poses a barrier to the …
-
The 52 and 60 kD Ro/SS-A : antigens where are they? : do anti-Ro/SS-A autoantibodies cause cutaneous disease?
… (whole 52 kD protein) and human sera (using two immunodominant regions of the protein). I affinity-purified antibodies to the 60 kD Ro from immunised rabbits (whole 60 kD protein) and human sera (using two immunodominant regions of the protein, as well as the total "native" protein). Using these …
-
Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection
… and proliferation assays were used to identify immunodominant ESAT6 and CFP10 15mer peptides targeted by CD8 T cells in LTBI and TB donors. A multiparameter flow cytometry panel was designed and optimized to assess turnover, susceptibility to apoptosis and terminal differentiation/senescence in …
-
Surveillance of Emerging Livestock Viruses
… binding and fusion during entry. Therefore, immunodominant neutralizing epitopes of PEDV were identified using a panel of S-specific mAbs. Epitope mapping by peptide ELISA revealed that seven mAbs recognized linear neutralizing epitopes located in the N-terminus of the S2 glycoprotein …
-
Peptide immunotherapy in models of allergic airways disease
… involves therapeutic administration of short immunodominant peptides from within the protein allergen to which CD4+ T cell responses are directed. This approach can induce tolerance of allergen-reactive CD4+ T cells, while negating the risk of severe allergic reactions associated with whole …
-
Immunology and virology of HIV-1 infection in Cameroon
… broad recognition, but failed to identify highly immunodominant peptides between homogeneous and diverse HIV epidemics. Further refinement of these immunogens may contribute to the development of a globally relevant vaccine. Finally, the use of PTE peptides did not increase the breadth of T cell …
-
Understanding the function of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis
… following in vitro stimulation with AChR or the immunodominant AChR alpha-subunit peptide 146-162. In vivo, the lack of ICOS costimulation led to diminished B cell and plasma cell expansion, whereas the number of CD4+ T helper cells was increased. Collectively, these results indicate that …
-
Ehrlichia chaffeensis Type 1 Secreted Effector TRP47 is a Novel SUMOylated Nucleomodulin
Ehrlichia chaffeensis secretes immunodominant and immunoprotective protein effectors into the host cell using a type I secretion system. The best-characterized of these effectors are the tandem repeat proteins (TRPs). In this study, E. chaffeensis TRP47 was identified as a target for host cell …
-
A Novel Platform to Generate Synthetic Vaccine Candidates
… immune response by undergoing rapid mutations in immunodominant epitopes [4-6]. In addition, although they usually express conserved epitopes that are important for inducing neutralizing antibodies, in many cases these are not immunodominant. Traditional techniques in vaccine development have not …
-
Candidate Bivalent HCV Vaccine: A Novel Approach To Vaccine Design for Hyper-variable Viruses
… it has been proposed that highly variable, immunodominant epitopes should be amputated from HCV vaccine antigens to avoid induction of strain-specific antibodies, as a proof-of-concept our approach was used to develop a bivalent HCV vaccine explicitly designed to elicit AB to HVR1 …
-
Cloning, Expression, and Characterization of Ara h 3, a Major Peanut Allergen
… option. In the United States, there are three immunodominant allergic proteins accountable for patient sensitization to peanut, Arachis hypogea 1, 2, and 3 (Ara h 1, Ara h 2, Ara h 3). Therefore, research into why peanuts are more allergic than other foods that have homologous proteins is …
-
Immunological and Molecular Analyses of the Borrelia burgdorferi OspF Protein Family F
… of OspF proteins during infection and mapped the immunodominant epitopes which lie within the variable domains. To determine if OspF-related proteins are produced by other isolates, immunoblot analyses were performed using sera collected from mice and humans infected with diverse B. burgdorferi …
-
B CELL EPITOPE MAPPING OF RIVAX, A CANDIDATE RICIN VACCINE ANTIGEN
… toxin neutralizing antibodies recognized four immunodominant regions on RTA i.e. four epitope clusters (namely cluster I to IV). RTA’s active site is surrounded by cluster III. Surprisingly, mAb IB2, which defines cluster III is the only antibody that recognized this immunodominant region. We …
-
A novel model system for the study of anti-tumour T-cell memory
… iPEC were shown to be recognising the immunodominant peptide of ß-gal (aa 876-884), and, consistently, the iPEC exerted specific lysis of ß-gal<sup>+</sup> cells. Upon adoptive transfer into sublethally irradiated, ESbL-Gal tumour-bearing, athymic Balb/c nu/nu mice, they conferred …
-
Modulation of the T cell response with MHC class I peptides and their analogues
… RT1l) rat strain combination. Secondly, the immunodominant allopeptide was selected to generate analogues in order to investigate their modulatory capacity. All peptides were tested in vitro in a standard proliferation assay and in vivo using a heterotopic heart transplantation model. Our …
-
New Approaches to the Development of Peptoid Vaccines
… that elicit these antibodies are often not immunodominant and even when they are, characterizing and synthesizing them can be difficult, particularly if they are conformational. The long-term goal of this work was to develop prophylactic vaccines that elicit such antibodies without epitope …
-
Characterising the immune response to Salmonella and Salmonella surface antigens during a systemic infection
… the flagellar protein FliC, which are potent, immunodominant antigens and frequent targets of antibody, that may offer potential as vaccine candidates have been examined. Immunisation with soluble flagellin (sFliC) induces a potent Th2 response. Despite this, immunisation with sFliC results in …
Page 1 of 3