Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"immunodeficient mice"”.
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Differential Screening in Immunodeficient Mice Reveals Bacterial Enzymes With Unexpected Roles in Host-Pathogen Interactions
… virulence in strains of immuno-deficient mice, we identified five enzymes required for in vivo survival in the face of specific immune stresses: four Mtb enzymes essential for growth and rapid lethality in NOS2- deficient mice but not in IFN-y-deficient mice, and one S. typhimurium enzyme …
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In Vivo Studies of the Foreign Body Reaction to Biomedical Polymers
… foreign body reaction with specific lymphocytic immunodeficient mice mainly targeting IL-4 (interleukin-4) cytokine. The experiment consisted of in vivo subcutaneous implants of polyether urethane (PEU) and polyethylene terephthalate (PET) in immunodeficient mice strains. Analysis on polymer …
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Autocrine prolactin signaling in breast cancer cells leads to metabolic changes and therapeutic opportunities for anti-tumour and anti-bone metastatic treatment
… for their ability to grow in the bone of immunodeficient mice and subsequently engineered to secrete human PRL (hPRL), as a model of autocrine hPRL-producing bone metastatic breast cancer cells. I found that the cells secrete hPRL into the culture media and respond to hPRL via signal …
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The Role of Inflammatory Lipid Mediators on Colon Cancer Initiating Cells (CICs)
… formation and tumor progression in xenograft mice model. The ALDH+ cells were also resistant to 5-fluorouracil and radiation that is additionally augmented by both the lipid-mediators. Moreover the impact of lipid inflammatory mediators on the stemness properties of CICs was evident by …
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The Effects of Electrochemical Therapy on Colon-25 Tumors in Balb-C Mice
The purpose of the research was to treat immunodeficient mice, implanted with colon-25 tumors, with continuous and interrupted electrochemical therapy (ECT). ECT involves the placement of two electrodes, an anode near the center of the tumor and a cathode into the tumor periphery. A constant …
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Immunomodulation by subclinical persistent infection with Helicobacter hepaticus
… is subclinical and persistent in C57BL/6 mice, but causes disease in susceptible strains and immunodeficient mice. To test the hypothesis that subclinical persistent infection modulates the host response to diarrheal disease a polymicrobial mouse model utilizing H. hepaticus and C. …
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Investigating immune surveillance, tolerance, and therapy in cancer
… on chemically-induced and spontaneous tumors in immunodeficient mice or on transplanted tumors. Such systems are limited because they fail to reproduce the complex interactions that exist among an emerging tumor, its microenvironment and the multiple elements of an intact immune system. We …
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Role of Nucleosome Remodeling Factor (NURF) in Tumorigenesis Using a Breast Cancer Mouse Model
… NURF function in tumorigenesis in vivo. BALB/c mice challenged with syngeneic 67NR breast cancer cell lines, injected into the mammary fat pad, lacking NURF, due to knockdown of its essential subunits Bptf, showed reduction in tumor growth comparing to control tumors. The observed reduction in …
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MICRO-CT EVALUATION OF MSC/HUVEC/HSC-MEDIATED ANGIOGENESIS IN LARGE PCL-ßTCP CONSTRUCTS IMPLANTED IN NUDE MICE
… sealed with fibrinogen, and implanted into immunodeficient mice for 8 weeks. At the end of the 8th week, mouse blood vessels were perfused with radiopaque microfil. The scaffolds were harvested, demineralized and analyzed for neovasculature by microcomputed tomography (micro- CT). The …
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Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth
… suppresses human pancreatic tumor growth in immunodeficient mice. In summary, our results suggest the existence of a physical and functional coupling of CXCR2 and PLC-β3 mediated through NHERF1, forming a macromolecular complex that is critical for efficient and specific CXCR2 signaling in …
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Novel Effects of Simvastatin on Uterine Fibroids
… fibroid cells. For the in vivo studies, we used immunodeficient mice supplemented with estrogen/progesterone pellets xenografted with human fibroid tissue explant. We found that simvastatin inhibits the proliferation of human fibroid cells. This was associated with decreased mitogen-activated …
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Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis
… (luminal A and basal-like, respectively) into immunodeficient mice, monocytes promoted the generation of an activated tumor stroma and were preferentially recruited to basal-like tumors. Furthermore, monocytes from breast cancer patients were affected early during the disease, gradually …
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Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia
… and in normal hematopoiesis was investigated. Mice deficient for the Socs2 gene displayed normal steady-state hematopoiesis and hematopoietic stem cell (HSC) function. Transduction of bone marrow (BM) cells from Socs2-deficient mice with BCR/ABL1 and subsequent transplantation resulted in a …
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Molecular defects in B lymphocytes from patients with CVID- syndrome
… of two CVID patients into the spleen of immunodeficient mice showed that the functional B cell integrity was restored in one patient after 21d, (as measured in terms of IgG production), whereas in the second patient the serum antibody concentrations were only low. Analyses of CVID lymph …
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THREE DIMENSIONAL IN VITRO MODEL OF HEAD AND NECK SQUAMOUS CELL CARCINOMA
… to the same tumor cell line grown in vivo in immunodeficient mice. We also investigated drug sensitivity of tumor cells in our model compared to conventional monocultures to determine whether differences exist. Finally, we investigated pro-angiogenic properties of tumor cells in this model. …
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Integrin α2 and Akt in early hematopoiesis
… limiting-dilution xenotransplantations using immunodeficient mice. Second, we revealed that integrin α2, which is a marker for megakaryoctyes and platelets, was not expressed in the immature CD34+CD38-CD45RA- bipotential megakaryocyte-erythrocyte progenitors in human bone marrow, providing a …
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B-cell development and function in the absence of the spleen
… unknown. We used congenitally asplenic Hox11-/- mice to study the function of the spleen for the development of B cells and the immune response to streptococcal polysaccharides. The absence of the spleen is not associated with a defect in the generation of mature B cells, but B-1a cells are …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
… route was observed in immunocompetent mice when compared to immunodeficient mice. Characterisation of the differences in the tumour microenvironment revealed a higher infiltration of neutrophils in the tumours with lymph node metastasis. Depletion of neutrophils reduced lymphatic …
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Generation and Characterization of Flavivirus Receptor-Binding Domain Mutants and Chimeras
… This virus was significantly attenuated, even in immunodeficient mice, suggesting that receptor-binding had been significantly impaired. Mutations present in isolates from mouse brains suggested that the G331A mutant could be compensated for, presumably through the alteration of receptor usage. …
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Role and specificity of regulatory T cells during retroviral infection
… a system was developed using infection of immunodeficient mice with Friend virus (FV). FV is a murine retroviral complex, which causes non-cytopathic persistent infection of hematopoietic cells. The results obtained suggested that unregulated CD4+ T cell response to FV causes bone marrow …
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