Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 657 for “"immunodeficiency"”.
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MOUSE MODELS OF IMMUNODEFICIENCY
… useful for the morpho-phenotypical assessment of immunodeficiency in 4 different immunodeficient mouse strains. The study also provided a comparison of the strengths and weaknesses of different laboratory methods for the identification and grading of immunodeficiency in the models. Our next step …
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Genomic investigation of primary immunodeficiency
… and TRAF3. In two families with autoimmunity and immunodeficiency I investigated the impacts of heterozygous deleterious variants in SOCS1. Patients showed reduced suppressor of cytokine signalling 1 (SOCS1) protein leading to enhanced signal transducer and activator of transcription 1 (STAT1) …
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The Virome in Primary and Secondary Immunodeficiency
… to reinforce the dogmatic opinion that to ‘cure’ immunodeficiency, one needs only to resolve and prevent recurrence of bacterial and fungal infections. However, reports of long-term health problems in immunocompromised cohorts suggest that treatment of bacterial and fungal infections alone does …
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Exercise and Immunodeficiency Affect Immunoglobulins in Endurance Horses
Two studies were conducted on endurance horses predominantly of Arabian breeding participating in an 80 km ride dedicated to research in April 2001 (Trial 1) and April 2002 (Trial 2). Objectives were to determine effects of endurance exercise, antioxidant supplementation, and a feed rich in fiber …
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Genetic characterization of human immunodeficiency virus from Northern South Africa
Globally, human immunodeficiency virus type 1 (HIV-1) is extraordinarily variable, and this diversity poses a major obstacle to AIDS vaccine development, diagnosis and therapy. Since HIV-1 M group began its expansion in humans roughly 70 years ago it has diversified rapidly now comprising a number …
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A mouse model for the pathogenesis of immunodeficiency virus infection
… CD4+ T cell killing in a virus-free mouse model. Immunodeficiency viruses are highly selective for activated/memory and regulatory CD4+ T cells due to restricted expression of CCR5, the co-receptor for HIV and SIV, or CD134 (OX40, TNFRSF4), the cellular receptor for FIV. Activated CD4+ T cells …
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Developmental Resilience to Dopaminergic Vulnerability Associated With Human Immunodeficiency Virus
<p>HIV can induce marked and debilitating neurologic complications in infected children, often in spite of the use of Highly Active Antiretroviral Therapy. Clinical observations suggest a specific vulnerability of dopaminergic neurons, yet few studies have examined the possibility that these …
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Construction of a Simian Immunodeficiency Virus Vaccine from Cynomolgus Macaque Cytomegalovirus
The current HIV pandemic has killed more than 35 million people since 1985, and infects a further 30 million globally. Vaccines based on herpesvirus vectors, in particular cytomegalovirus, generate unique, robust immune responses that may overcome many of the typical obstacles to an effective …
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The pivotal role of dendritic cells in feline immunodeficiency virus infection
Feline immunodeficiency virus (FIV) is the feline counterpart to human immunodeficiency virus. Dendritic cells (DC) are one of the first cell types encountered during lentivirus infections. The studies set forth in this dissertation initiated investigations into the interactions of FIV and DC. …
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Platinum and palladium complexes as human immunodeficiency virus latency reversal agents
… presents a formidable challenge in human immunodeficiency virus (HIV/AIDS), numerous efforts have been made to develop vaccines and chemotherapeutic agents. However, an effective vaccine remains elusive, and existing HIV/AIDS medications do not lead to a cure. Antiretroviral therapy (ART) …
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Factors affecting replication and cross-species transmission of feline immunodeficiency virus
… such as entry receptors for replication. Human immunodeficiency virus (HIV-1) infection is blocked at a post-entry stage by rhesus macaque TRIM5α, an effect that is enhanced by host factor cyclophilin A (CypA), but largely evades restriction by the human TRIM5α variant. HIV-1 replication is also …
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In vivo and in vitro studies of immunodeficiency in Ataxia-telangiectasia
… An immediate consequence for A-T patients is an immunodeficiency that is not progressive, but may be described as ‘congenitally aged’. Immunodeficiency per se is not the cause of cancer in A-T but both immunodeficiency and cancer are consequences of the same basic ATM defect affecting the …
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Whole Blood Mitochondrial DNA Depletion in Human Immunodeficiency Virus-Infected Children
… known about mitochondrial DNA (mtDNA) in human immunodeficiency virus (HIV) infected children who face a lifetime exposure to these agents. We performed a cross sectional observation of mtDNA levels in whole blood in a pediatric population to ascertain the relationship between mtDNA, NRTI …
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Influence of Human Immunodeficiency Virus and other risk factors on tuberculosis
… the last two decades mainly because of the Human Immunodeficiency Virus (HIV) epidemic. Globally, it was estimated that 73% of the TB cases were co-infected with HIV with more than 25% of this global co-infection burden being in South Africa alone. In 2012, globally 1.3 million deaths occurred due …
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Assessment of nutritional status in patients with acquired immunodeficiency syndrome (AIDS)
… out on thirteen patients with the Acquired Immunodeficiency Syndrome (AIDS). Estimates of body fat and skeletal muscle were measured using triceps-skinfold, mid-arm circumference, mid-arm muscle area, and creatinine height index. Body weight was compared to standards for height and sex. …
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