Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"immunocytokine"”.
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Immunostimulatory activity and antitumor efficacy of mSOT201 immunocytokine
… and low efficacy. Here, we evaluated mSOT201 immunocytokine consisting of an IL-15 mutein linked through short flexible oligopeptide linker to IL-15Rα sushi+ domain and fused to the C-terminus of anti-mouse PD-1 mAb, thereby directing the cytokine payload to PD- 1⁺ tumor infiltrating …
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Improving methods for cytokine immunotherapy of cancer
… toxicity often limits dosages. Although immunocytokines have been designed with the intent to localize cytokine activity, systemic dose-limiting side effects are not fully ameliorated by attempted tumor targeting. In the first part of this work, we used the B 1 6F 10 melanoma model to …
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Generation and in vivo validation of multi-functional antibody-fusion proteins for cancer therapy
… is the development of systemic side effects. Immunocytokines, which combine antibodies against a tumor-associated antigen with the immunomodulatory properties of cytokines, represent a promising strategy to overcome these limitations. This approach aims to concentrate their biological activity …
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Integrin-targeted cancer immunotherapy
… as a targeting moiety for delivering IL-2 as an immunocytokine failed. Mathematical modeling results indicated that immunocytokines, unless adhering to specific design criteria, are unlikely to benefit from targeting and may actually exhibit limited efficacy. Therefore, we "deconstructed" this …
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ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
… antibodies, antibody-drug conjugates, and immunocytokines have transformed human oncology, their application in veterinary medicine remains limited by scant data on druggable targets in dogs. This doctoral thesis aimed to systematically assess the expression and distribution of selected …