Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2076 for “"immunity"”.
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Immunity in kwashiorkor
The adverse effects of malnutrition on the child are diverse and complex. This thesis describes an examination of the effects of severe malnutrition on immune defence mechanisms and in particular on cellular immune function in vitro.
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Vip And Host Immunity
… was to examine how VIP regulates host immunity and corneal healing, specifically, its control of growth factors and TLR expression in the P. aeruginosa infected cornea. Firstly, VIP treatment increased growth factor expression (EGF, GHF, FGF and VEGF) in infected cornea. Notably, …
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Defensins In Ocular Immunity
<p>Corneal infection with P. aeruginosa results in corneal perforation in susceptible</p> <p>B6, but not resistant BALB/c mice. This study explored their role mBD 1-4 in corneal</p> <p>infection, and their potential synergy. Immunostaining and real-time RT-PCR data</p> <p>demonstrated that their …
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Autophagy in Antiviral Immunity
… evidence that autophagy functions in innate immunity to viruses. In the second study, we found that the host autophagy gene Atg5 was required to protect against lethal Sindbis virus CNS diseases, and that autophagy targeted viral proteins for degradation in brains of infected mice and cells …
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Protective Immunity in Atherosclerosis
… development of atherosclerosis. The protective immunity induced by the apoB-100 peptide vaccine aBp210 is associated with an activation of Tregs indicating that specific activation of Tregs could be a promising target in immune modulating therapies. Activation of the inhibitory Fcgamma receptor …
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Immunity to Trichinella Spiralis
Summary: p. xii-xv.
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NUTRITION AND IMMUNITY: MOLECULAR APPROACHES
… important role in modulating livestock species immunity. Therefore, this thesis aimed at evaluating the effects of different dietary molecules used in animal nutrition on mammalian and avian immunity. Both, in vitro functional analyses and OMIC technologies (proteomics and miRNAomics) were …
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Immunity to Leishmania mexicana parasite
Background: Cutaneous Leishmaniasis caused by the Leishmania mexicana complex is associated with unpleasant or disfiguring lesions, for which there only limited treatment options. The life cycle of L. mexicana consists of two stages which involve different immune evasion mechanisms: promastigote …
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Regulatory Mechanisms in Innate Immunity
Innate immunity is the frontline for the host to defend against infections. This process entails the cooperation among pathogen recognition receptors, adaptor proteins, kinases, and transcription factors that elicit the production of effector cytokines. As an important transcription factor, IRF5 …
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Adaptive Immunity in Cardiovascular Disease
… This thesis presents and discusses aspects of immunity, which are interesting targets for pharmaceutical intervention. Various components of adaptive immunity may be useful as biomarkers for determining patients with increased risk of developing CVD.
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Maternal Modulation of Neonatal Immunity
… that activation of maternal inflammatory immunity during pregnancy influences maturation of the neonatal immune system.</p> <p>Lymphocytes in blood and spleen were immunophenotyped by flow cytometric analysis to determine differentiation characteristics, and splenocytes were assessed for …
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Molecular recognition in plant immunity
Plant pathogens constitute a major threat to global food security. The use of naturally resistant crop varieties can limit crop losses, however new races of pathogen can arise that are able to overcome these defences. Plant breeding for race-specific resistance typically relies on …
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The Evolution of Drosophila Immunity
… selection force on the evolution of Drosophila immunity. Under the pressure of this natural selection by pathogenic organisms, species diverge along the evolutionary path and depart in phenotypes. Interspecific differences in gene expression are an important contributor to this divergence where …
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Determinants of Immunity against the Meningococcus
… spread N. meningitidis and thus eliciting herd immunity within a vaccinated population. Within this thesis, I aimed characterize vaccine elicited immune processes necessary for protection against meningococcal nasal colonization and invasive sepsis. To characterize vaccine elicited protection …
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Impact Of Cryoablation On Tumor Immunity
… has the potential to initiate or amplify tumor immunity through the release of tumor-associated antigens and endogenous danger signals. However, enhanced immunity is rarely observed in treated patients, suggesting the need for mechanistic analysis. The goal is to determine how cryoablation …
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Fibroblast Heterogeneity In Pancreatic Cancer Immunity
… with opposing roles in PDAC progression and immunity.</p>
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Neutrophil diversity in immunity and inflammation
Contains fulltext : 239947.pdf (Publisher’s version ) (Open Access)
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Human Cellular Genetics of Innate Immunity
… frequently enriched. Returning to innate immunity, Chapters 4 and 5 centre on variability in the type I interferon response. I first describe work linking variability in the innate immune response and evolutionary divergence across mammalian species. Focusing on human variability, the …
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TRIM21 Mediated Antibody-Dependent Intracellular Immunity
… 1890s, revealing their importance in protective immunity and allowing their development in numerous research and therapeutic applications. However, these studies have focused almost exclusively on the extracellular effector mechanisms of antibodies such as opsonisation, complement activation, …
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