Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"immune-mediated diseases"”.
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Clustering of immune-mediated diseases using genomic data
Studying immune-mediated diseases (IMD) yields insights into the active immune system. In this thesis I cluster patients with IMD based on RNA-seq data using two extensions to clustering, and also cluster the diseases themselves using GWAS summary statistics. I conducted an extensive study of …
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Investigating the role of MyD88 signalling pathway in immune mediated diseases
… protein (MyD88) plays a central role in innate immune signalling by acting as an adaptor protein downstream of most of the Toll-like receptor (TLR) family and all the IL-1 receptor family members. Activation of MyD88 dependent signalling is critical for the immune response during infections, …
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Understanding the role of CD4+ T cells in common immune-mediated diseases
Immune-mediated diseases such as autoimmunity are complex traits which collectively affect around 10% of the European population. Genome-wide association studies (GWAS) have demonstrated that genetic susceptibility to these diseases is explained by thousands of loci spread throughout the genome, …
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INVESTIGATING IMMUNE SYSTEM REGULATION THROUGH CROSS-DISEASE GENETIC ANALYSIS AND B CELL FATE DECISIONS
Autoimmune diseases cluster into families, suggesting a shared genetic mechanism. Common genetic causes might indicate shared pathogenic mechanisms that cross-disease therapies could target. In this thesis, I investigated the genetic relationship among nine immune-mediated diseases. I identified …
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Systems analysis and characterization of mucosal immunity
During acute and chronic infectious diseases hosts develop complex immune responses to cope with bacterial persistence. Depending on a variety of host and microbe factors, outcomes range from peaceful co-existence to detrimental disease. Mechanisms underlying immunity to bacterial stimuli span …
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Statistical methods to improve understanding of the genetic basis of complex diseases
… resolve the genetic aetiology of complex human diseases including immune-mediated diseases. Essential to this process is firstly the use of genome-wide association studies (GWAS) to identify regions of the genome that determine the susceptibility to a given complex disease. Following this, …
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Modulation of macrophage metabolism and function by the helminth peptide FhHDM-1
… strategies to regulate their host’s immune response, to prevent expulsion and establish chronic infections. Understanding how they achieve this offers a therapeutic strategy for the treatment of human diseases which are caused by unregulated inflammation. Previous characterisation of …
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Obesity in Patients with Inflammatory Bowel Disease // Затлъстяване при пациенти с хронични възпалителни болести на червата
… such as miRNAs that may control both the immune system and meta-inflammation in obesity represents an ideal candidate for the evaluation of patients with IBD and overweight or obesity. On the other hand, recently, circulating levels of human Lipocalin-2/NGAL have been successfully linked …
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SYSTEMS BIOLOGY APPROACHES TO DECIPHERING COMPLEX IMMUNE RESPONSES
Many diseases, including cancer, autoimmunity, infections, and allergies, are associated with dysregulation of immune responses. Therapeutic strategies targeting the immune system have succeeded in treating a wide range of diseases. However, we lack the detailed understanding of the immune system …
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Relationships between psychological factors and immune dysregulation in context: a life-course approach
… exposures, psychological responses to them and immune dysregulation. The approach taken is informed by theories about the life-course, the stress process, the stress response and the inflammatory theory of depression. The first two empirical chapters provide evidence about the contribution of …
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Decoding CD4+ T cell activation by multi-modal phenotyping
… T cells is strongly implicated in the biology of immune-mediated diseases, yet the molecular and functional mechanisms governing this process remain incompletely understood. With the explosion of profiling and functional genomic methods in the last decade, it is now feasible to interrogate the …
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BACH2 orchestrates thymic T cell differentiation and functional programming
… and has important implications for understanding immune-mediated diseases and translation of adoptive T cell therapies.
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Single-cell transcriptomics identifies key components in metabolic pathways of drug perturbed activated CD4+ T cells
… play a critical role in the development of autoimmune diseases. During CD4+ T cell activation, remodelling of metabolic pathways is required for the cells to exert their effector functions. The importance of these pathways is highlighted by the successful therapies for immune diseases that …
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Transdisciplinary Strategies for the Characterization of Mucosal Immune Responses to Enteric Pathogens
The gastrointestinal mucosal immune system has the daunting task of maintaining immune homeostasis by eliminating potentially harmful microorganisms and limiting tissue injury while inducing tolerogenic responses to luminal antigens including innocuous food, commensal bacteria and self-antigens. …
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Decoding division: single-cell insights into the transcriptional, proteomic and metabolic regulation of proliferating CD4+ T-cells
Understanding the immune system is central to developing effective treatments for immune-mediated diseases (IMDs). CD4+ T-cells, as key orchestrators of adaptive immunity, encompass a diverse range of subtypes that coordinate and regulate the immune response. Advances in immunogenomics have …
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Transdisciplinary Strategies to Study the Mechanisms of CD4+ T cell Differentiation and Heterogeneity
… panoply of lymphoid cell subsets in the human immune system. CD4+ T cells are able to differentiate into either effector pro-inflammatory or regulatory anti-inflammatory subsets depending on the cytokine milieu in their environment. This complex process is mediated through a variety of …
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Molecular and clinical profiling of immune disease genetic loci
… genetic variants linked to various traits and diseases, including immune-mediated diseases (IMD). However, understanding the downstream effects of these genetic variations, both at the molecular and clinical levels, has proven more challenging than expected in the postGWAS era. To address these …
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Characterising the gene regulatory landscape of CD4+ T cells
Despite the high prevalence of immune-mediated diseases, the molecular mechanisms by which they arise and the influence of genetic variation in the predisposition to disease are not well understood. Immune susceptibility loci identified by genome wide association studies (GWAS) overlap with active …
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Ctla-4 transcriptional activation: regulation of induced expression
… have shown efficacy to quell the overactive immune system in various types of autoimmune diseases. Alternatively, blocking antibodies to CTLA-4 have been used in cancer therapies to boost the anti-tumor immune response. Malignant cells of cutaneous T cell lymphoma (CTCL) express elevated …
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Common variants in antibody deficiencies
… immunity (IEIs) comprise a group of almost 500 diseases charac- terised by immune dysfunction of genetic origin. Many of these disorders represent canoni- cal examples of Mendelian disease and study of their genetic aetiology is largely conducted within a rare-variant, monogenic paradigm. …
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