Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"immune transcriptome"”.
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Immune Transcriptome and B cell receptor repertoire in COVID-19
… disease to multi-organ failure. We studied the immune response of SARS-CoV-2-infected individuals with a range of severities followed over 2- 6 months from symptom onset. We undertook deep immune-phenotyping and transcriptomic analysis. We demonstrated that an early robust immune response, …
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BREAST CANCER DURING PREGNANCY AS A SPECIAL TYPE OF EARLY-ONSET BREAST CANCER: INSIGHTS INTO THE TUMOR MICROENVIRONMENT AND IMMUNE TRANSCRIPTOME
… is a rare tumor with limited information on its immune landscape. Here, we sought to characterize the cellular composition of the tumor microenvironment (TME) and the immune transcriptome of PrBC to identify their differences from early-onset breast cancer (EOBC) in non-pregnant women. …
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The Majority of the Diaphragm Immune Transcriptome Profile Rescued in Mdx Mice by Microdystrophin Gene Therapy was maintained by Voluntary Wheel Running
… of this thesis project was to elucidate the immune transcriptomic changes in the diaphragm of mdx mice treated with microdystrophin gene therapy with and without running wheel activity. Mdx mice are a model of Duchenne Muscular Dystrophy (DMD). Similar to DMD, mdx pathophysiology is …
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Recessive and rare variant effects on common diseases and the immune cell transcriptome
… in G&H with rare, putative LoFs affecting immune genes, for single-cell RNA-sequencing (scRNAseq) of peripheral blood mononuclear cells (PBMCs). Cell-type-specific LoF effects on transcription have yet to be studied at scale, and in my thesis I discuss the three phases to building this …
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Host Immune-Microbial Interactions in Inflammatory States
… state characterized by both persistent immune activation and immune suppression. Patients afflicted with chronic inflammatory diseases such as end-stage renal disease and sarcoidosis face increased susceptibility to infection as well as mixed responses to vaccination. Thus, the extent to …