Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"immune tolerance"”.
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Investigating the immune modulatory properties of kisspeptin: implications for pregnancy
… is dependent on the development of maternal immune tolerance to the genetically foreign fetus. During pregnancy the mother's immune reactivity and energy metabolism undergoes significant changes and the levels of certain hormones in peripheral blood are significantly increased. Hormones are …
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Biological effects of synthetic biomolecules that may either mimic or antagonise the function of hCG in the development of cancer and autoimmune disease
… pregnancy, partly by promoting maternal immune tolerance to fetal antigens. It achieves this by expanding immunoregulatory cells such as tolerogenic dendritic cells, regulatory T cells (Tregs), and regulatory B cells (Bregs). Interestingly, hCG is also secreted by certain tumours, helping …
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Studies of immune biology of the common marmoset: a novel non-human primate transplant model.
Donor-specific immune tolerance is a highly desirable goal in clinical transplantation. Dendritic cells (DC) are potent immune system regulators, and promoting both anti-donor immunity and immune tolerance. DC are therefore an important target for potential tolerance-inducing therapies, which must …
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Examining the Role of Regulatory Lymphocytes in a Mouse Model of BCL1 Tumor Dormancy
… cells play a key role in maintaining systemic immune tolerance and have been described to promote cancer progression. The objective of this study was to determine the role of Treg cells in preventing BCL1 tumor dormancy by suppressing the anti-tumor immune responses. Surprisingly, we found that …
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Role of T cells and cytokines in the induction of tolerance to renal tubular antigen in active Heymann nephritis
… lymph nodes. These findings suggest that immune deviation to a Th2 response reduces glomerular injury in HN. Second, the role of CD4+ T cells in immune tolerance was examined. Rats were given RTA in incomplete Freund's adjnvant (lFA) to induce tolerance to RTA, and three weeks later were …
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Metabolomic analysis of the interleukin-10-deficient mouse model of Crohn's disease
… to Crohn’s disease, due to the loss of immune tolerance towards intestinal microbiota. Metabolomic analysis is the study of small molecule metabolites, involving the measurement of large numbers of metabolites in biological samples. The aim of the research was to study the urinary …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
… highlighting a need for greater understanding of immune regulation by lymphatics. The specific role of lymphatic endothelial cells (LECs) in this context, particularly in TDLNs, is unknown. As TDLNs are immune hubs, yet anti-tumour immune responses are often ineffective, this thesis aimed to …
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Investigation of CD4+ T cell heterogeneity and function in a genetic mouse model of lung adenocarcinoma
The clinical success of immune checkpoint blockade in the treatment of various cancers provides proof-of-concept that disrupting tumor immune tolerance is an effective therapeutic strategy. Nevertheless, only a subset of patients respond to immune therapies, suggesting that an improved …
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T-cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T-cells
… (Treg) play an important role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses in the host. The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3<sup>+</sup>) Treg and conventional T (Tconv) cell populations …
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Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation
… inflammation. Moreover, specific populations of immune cells exert cell-extrinsic effects for immunosuppression. Therefore, studies on the immunosuppressive functions of these cell populations will provide a better understanding of how inflammation is regulated and how its dysregulation causes …
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Structural and molecular studies of group II leukocyte immunoglobulin-like receptors.
… LILRB4, and its role in the induction of immune tolerance via its actions upon dendritic cells and T cells. I attempted ligand-identification and structural studies on LILRB4. Staining of human PBMCs with multimeric LILRB4 revealed broad expression of the ligand, and upregulation on …
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Molecular Players in Lupus: Leads from Proteomic Screens
… Erythematosus is a multifactorial systemic autoimmune disorder marked by anti-nuclear antibodies (ANA), rashes and photosensitivity, joint inflammation, nephritis, and other clinical criteria. SLE develops through the breakdown of three major checkpoints: adaptive immune tolerance, peripheral …
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Rerouting Pre-Existing Host Vaccine-Induced Immunity to wards Breast Cancer
… investigators have attempted to activate the immune system to prevent cancer metastasis or recurrence; however, owing to host immune tolerance to cancer antigens and the immunosuppressive environment at tumor sites, many such attempts have failed. The recent success of anti-CTLA4, PD-L1 and …
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MicroRNA and Epigenetic Controls of CD4+ T cells' Activation, Differentiation and Maintenance
<p>As a major component of the adaptive immune system, CD4+ T cells play a vital role in host defense and immune tolerance. The potency and accuracy of CD4+ T cell-mediated protection lie in their ability to differentiate into distinct subsets that could carry out unique duties. In this …
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Characterizing the role of thymic interferon in T cell development and selection
… cells against viral infection and activate immune cells. Curiously, both type I and type III IFNs were reported to be produced at low levels in the thymus in the absence of infection – the site of T cell development and a crucial organ for immune tolerance.To understand the impact of IFNs on …
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Exploiting Ruminococcus gnavus and Limosilactobacillus reuteri to strengthen host immunity and treat infections
… intestinal epithelium is tasked with balancing immune tolerance and anti-pathogen immunity. One way in which the mucosal epithelium maintains healthy host-microbiota interactions is by producing antimicrobial peptides (AMPs). Epithelium-derived AMPs represent an evolutionarily ancient defense …
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The Role of TGF-β in CTB-Insulin Regulated Human Dendritic Cell Tolerance
… Recent studies of CTB-INS induction of immune tolerance in human DCs indicate that increased IDO1 biosynthesis may play an important role in CTB-INS vaccine inhibition of DC activation. Previous studies suggest transforming growth factor beta (TGF-β) may play a role in the stimulation of …
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Design of Antigen-Specific Immunotherapies Through Modulation of Peripheral Tolerance Pathways
Current therapies for autoimmune diseases lack specificity for the offending immune cell population resulting in a wide range of side effects and weakening of the immune system. This presents a clear need for antigen-specific immunotherapies (ASITs) capable of selectively modulating autoreactive …
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Characterization of Regulatory Mechanisms in Mucosal Immunity by Systems Immunology
… highly specialized and dynamic system of immune components that aim to protect the gut from external threats. The sustained exposure of the mucosal immune system of the GI tract to an enormous number of lumen antigens, requires the constant upkeep of a highly regulated balance between …
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Screening and Functional Analysis of New Anti-Complement Autoantibodies in the Course of Systemic Lupus Erythematosus // Скрининг и функционален анализ на нови анти-комплементни автоантитела в хода на системен лупус еритематодес
The role of autoimmunity and the loss of immune tolerance to own proteins have a significant place in the current ideas about the aetiology and pathogenesis of systemic lupus erythematosus (SLE). The disease is characterized by broad-spectrum organ manifestations, multiple autoantibodies and …
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