Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"immune therapy"”.
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DEVELOPMENT OF BISPECIFIC T CELL ENGAGERS TARGETING CARBONIC ANHYDRASE 9 FOR THE IMMUNE THERAPY OF CLEAR CELL RENAL CELL CARCINOMA
… the CA9-targeted dPMTE as a promising new immunotherapy against advanced ccRCC, alongside its format to repurpose for other cancers.
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The Immunosuppressive Function of VEGF Signaling in the Tumor Microenvironment
… growth factor-A (VEGF). As a result, anti-VEGF therapy is commonly employed for cancer treatment. However, anti-VEGF therapy generally provides modest efficacy in cancer patients and therapy-induced hypoxia results in a less differentiated mesenchymal-like tumor cell phenotype, which reinforces …
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Myasthenia Gravis mimics: An audit of cases identified at Groote Schuur Hospital over 20 years
… and pharmacological responses. Autoimmune MG will respond to immune therapy. Although there are several case reports of patients who were incorrectly diagnosed as MG, this study describes the MG mimics encountered at Groote Schuur Hospital, Cape Town, over a period of 20 years. Aims …
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APPLICATION OF STRUCTURAL, MOLECULAR, AND PROTOEMIC STUDIES TO INVESTIGATE ON-TARGET AND OFF-TARGET MECHANISMS OF LORLATINIB RESISTANCE IN ALK DRIVEN NEUROBLASTOMA
… a common childhood cancer, approval of anti-GD2 immune therapy has improved patient survival and discovery of anaplastic lymphoma kinase (ALK) receptor activating mutations and amplification has provided hope to further increase of patient survival. Despite this success and that of precision …
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Immune cell alterations in mouse models of prostate cancer
… that tumour cells have the ability to alter immune function to create an immune suppressed environment. This allows tumour cells to escape immune surveillance and consequently the tumour can progress. Dendritic and T cells have critical roles in immune activation and tolerance and are thus …
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Inhibition of adenosinergic signaling in the tumor immune environment: the effect of combination CD73 blockade and oHSV therapy on solid tumors
<p>Oncolytic HSV (oHSV) therapy is a live virus-based immunotherapy that lyses tumor cells which release antigens and activate anti-tumor immunity. Immunotherapy-based drugs have made significant advances in treating cancer. However, unchecked immune activation can escalate to autoreactivity or …
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Clinical and Therapeutic Significance of Obesity In Melanoma
<p>While the FDA approval of targeted and immune therapies in metastatic melanoma (MM) have dramatically improved outcomes in this disease, <em>de novo</em> and/or acquired resistance can limit the clinical benefit of these agents. The IGF-1/PI3K/AKT pathway has been implicated in resistance to …
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The cholesterol efflux protein ABCA1 skews macrophages towards an anti-tumor phenotype and consequently impacts cancer progression
… of metastatic breast cancer. While immunotherapy shows some effectiveness, it has only been approved for patients who stain positive for PD-L1. Previous research in our lab has shown that macrophage function can be regulated through disruption in cholesterol metabolism. Additionally, …
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Alpha-Fetoprotein-spezifische Immuntherapie des hepatozellulären Karzinoms mittels DNA-Immunisierung
Das hepatozelluläre Karzinom (HCC) ist in einigen Ländern der Erde einer der häufigsten malignen Tumoren. Die operative Resektion ist die einzige kurative Therapie des HCC, keine der alternativen Therapieoptionen, wie die perkutane Ethanolinjektion, die Radiofrequenzthermoablation oder die …