Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 97 for “"immune suppression"”.
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Mechanism of Chimeric Vaccine Mediated Immune Suppression of Human Dendritic Cells
… islets are killed by autoreactive cells of the immune system in response to a loss of tolerance. Dendritic cells (DC) interact predominantly with naïve T cells to regulate the delicate balance between immunity and tolerance required to maintain immunological homeostasis. In this dissertation, …
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Il-1Α Blockade Reduces Immune Suppression In The Early Tumor Micro-Environment
<p>IL-1α Blockade Reduces Immune Suppression in the Early Tumor Micro-Environment</p> <p>Brenda Melendez, B.S.</p> <p>Advisory Professor: Gregory Lizee, PhD.</p> <p>Immunotherapy against melanoma has shown great promise in the clinic for treating advanced-stage patients. However, a major barrier …
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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation To Promote Immune Suppression
… towards TAMs and away from DCs via suppression of DC-promoting transcription factor Irf4. Genetic inhibition of RA production by tumor cells or pharmacologic inhibition of RA signaling within the TME increased stimulatory monocyte-derived cells, enhanced T cell-dependent anti-tumor …
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Mechanisms of Evasion: Anti-Tumor Immune Suppression & TRNA-Dependent Growth in Cancer Metastasis
… that suppress both adaptive and innate immune responses. While our understanding of the molecular basis of adaptive immune suppression by cancer cells has led to the development of transformative immune checkpoint therapies, our knowledge of the molecular basis of innate immune …
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Molecular basis of porcine reproductive and respiratory syndrome virus-mediated innate immune suppression
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-05-01
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Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer
Checkpoint immunotherapy unleashes T cell antitumor potential which has revolutionized cancer treatment showing unprecedented long-term responses. However, most patients do not respond to immunotherapy which often correlates with a dysfunctional or immunosuppressive myeloid compartment. …
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The Indirect Effect of BVDV on Immune Suppression: The Role of Infected Macrophages in Lymphocyte Apoptosis
… economic losses. The main problem of BVDV is the immune suppression that is associated with lymphoid depletion shortly post infection. The mechanism of this immune suppression is not well understood. In this in vitro study, we sought to determine the indirect effect of BVDV infection in …
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The Role of Ganglioside GD2 and GD3 Synthase (ST8SIA1) in the Regulation of Immune Suppression in Breast Cancer
… gangliosides influence the activity of immune cells including macrophages, NK cells, and T cells. GD3 synthase (GD3S) is the key enzyme that regulates the biosynthesis of the b and c series gangliosides, particularly GD3 and GD2, and studies have shown that GD3S is upregulated in most …
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Immune Suppression By The Herbicide Atrazine Involves Inhibition Of CD4+ T Cells And Expansion Of Foxp3+ Regulatory T cells
… to it daily. ATR has been associated with immune dysfunction as well as other human health risks. The mechanism by which ATR suppresses the immune system has not been defined. It is known that ATR is a phosphodiesterase inhibitor, which causes intracellular accumulation of cAMP. …
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Immune Suppression By The Herbicide Atrazine Involves Inhibition Of CD4+ T Cells And Expansion Of Foxp3+ Regulatory T cells
… to it daily. ATR has been associated with immune dysfunction as well as other human health risks. The mechanism by which ATR suppresses the immune system has not been defined. It is known that ATR is a phosphodiesterase inhibitor, which causes intracellular accumulation of cAMP. …
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Elucidating essential roles of oomycee effector proteins in immune suppression and in targeting hormonal pathways in the host plant
Effector proteins are exported to the interior of host cells by numerous plant pathogens. Effector proteins have been well characterized in bacteria. However, the mechanisms through which these effectors promote virulence are largely unknown. Bioinformatic analysis of genome sequences from oomycete …
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Investigating the Role of Indoleamine 2,3-Dioxygenase 1 and Transforming Growth Factor Beta 1 in Rebound Immune Suppression Following Chemotherapy in Osteosarcoma
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Investigating the fibroblast activation protein alpha expressing stromal cell in a spontaneous murine model of pancreatic adenocarcinoma
… from cancer patients and animal models that the immune system is able to recognise cancer cells. It is unclear whether tumours escape this immune surveillance by selection of non-immunogenic variants in a Darwinian process termed cancer immunoediting, or by the recruitment of immune suppressive …
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CONSEQUENCES OF ARYL HYDROCARBON RECEPTOR ACTIVATION IN STEADY-STATE AND INFLAMMATORY DENDRITIC CELLS
… TCDD and TCDD congeners has been shown to cause immune suppression, yet the mechanisms underlying TCDD-induced immune suppression remain poorly understood. Dendritic cells (DCs) are professional antigen presenting cells (APCs) that play an integral role in both innate and adaptive immune …
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CONSEQUENCES OF ARYL HYDROCARBON RECEPTOR ACTIVATION IN STEADY-STATE AND INFLAMMATORY DENDRITIC CELLS
… TCDD and TCDD congeners has been shown to cause immune suppression, yet the mechanisms underlying TCDD-induced immune suppression remain poorly understood. Dendritic cells (DCs) are professional antigen presenting cells (APCs) that play an integral role in both innate and adaptive immune …
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Monitoring immune dynamics following infection and vaccination using B cell receptor sequencing
… of the genetic diversity underlying adaptive immune responses in health and disease. In the context of infectious diseases this can act as a powerful tool for identification of pathogen-specific immune signatures and genetic determinants of immune memory, protection and response to …
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Investigating the inhibitory effects of secreted proteins on macrophage in glioblastoma
… microenvironment of glioblastoma contributes to immune suppression and inhibition of T cell activity through secreted immuno-suppressive proteins and cytokines, dysfunction of immune cells and upregulation of immune checkpoint molecules. Macrophages are the most populous non neoplastic cells in …
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Immune cell alterations in mouse models of prostate cancer
… that tumour cells have the ability to alter immune function to create an immune suppressed environment. This allows tumour cells to escape immune surveillance and consequently the tumour can progress. Dendritic and T cells have critical roles in immune activation and tolerance and are thus …
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Childhood epidemics and the demographic landscape of the Aland Archipelago
… childhood diseases, research has shown that the immune response to measles infection results in immune suppression that can last for weeks or even months. Higher mortality during measles epidemics has typically been associated with completely susceptible populations; however, in Aland, Finland--a …
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Validation of AXL as a Therapeutic Target in Pancreatic Cancer
… rate that is associated with persistent immune suppression. AXL, a member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family, has been identified as a critical factor that drives metastasis and immune suppression in many cancer types. Here we demonstrate that AXL-deficient PDA …
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