Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"immune signaling"”.
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Defining the role of toll-like receptor 10 in immune signaling
… TLR family. Given the established role of TLR signaling in both the innate and adaptive arms of immune defense, defining the function of TLR10 in the immune response would fill a significant knowledge gap regarding the question of why the gene has been propagated through evolutionary history. …
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Structural Basis for the Activation of RIG-I/MAVS Antiviral Immune Signaling
The file named "XU-DISSERTATION-2015.pdf" is the primary dissertation file. The supplemental file named "Movie 1.mp4" may be viewed individually.
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Modulation of innate immune signaling pathways by the intracellular pathogen Toxoplasma gondii
… is likely due to its ability to modulate host immune responses and host innate immune signaling pathways allowing it to establish a chronic infection with few symptoms in its hosts, which favors transmission to new hosts. Here, we report that Toxoplasma activates NF-[kappa]B and inhibits STAT1 …
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Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
… disease. How cancer cells evade ensuing immune surveillance upon reactivation is poorly understood, but critical for the development of novel therapies to prevent metastatic relapse. Here, we identify focal adhesion kinase (Fak) as a critical regulator of metastatic reactivation and …
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Biological and Biochemical Characterization of Atypical Receptor-Like Cytoplasmic Kinases in Arabidopsis Immune Signaling
In plants, immune responses are initiated upon perception of microbial signals and are rapidly transmitted through intracellular networks largely governed by phosphorylation and ubiquitination - post-translational protein modifications catalyzed by protein kinases and E3 ligases, respectively. …
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THE ROLE OF SELECTIVE MRNA DEADENYLATION IN THE HOMEOSTATIC CONTROL OF INNATE IMMUNE SIGNALING
… conditions including autoimmunity. Interferon signaling is the specific antiviral arm of the innate immune system responsible for inducing interferons and downstream signaling to control viral infection. While much is known about the stimuli-dependent induction of interferons, less is known …
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Investigating The Effect Of Chronic Muscle Use And Disuse On Innate Immune Signaling In Skeletal Muscle
… mitochondrial perturbations can activate innate immune pathways, such as the NLRP3 inflammasome complex, by augmenting the response against damage-associated molecular patterns (DAMPs). The objective of this study was to investigate how various metabolic conditions affect innate immune activation …
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Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus
… encode proteins that counteract the innate immune response. A number of reports have indicated the papain-like protease (PLpro) domain of SARS-CoV Non-Structural Protein 3 (NSP3) as a powerful interferon antagonist, by suppressing interferon regulatory factor 3 (IRF3) dependent innate …
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Exploring the immunologic consequences of ATRX deficiency in glioma
… is known about the impact of ATRX mutation on immune signaling. Furthermore, little is known about the interaction of ATRX loss with gain-of-function mutations in IDH. In this paper we set out to explore the impact of ATRX loss on immune signaling in gliomas, both in the context or and absence …
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GENETIC REQUIREMENTS OF DANGEROUS MIX AUTOIMMUNITY IN ARABIDOPSIS THALIANA
… often found in hybrid plants due to uncontrolled immune responses without obvious pathogenic attacks. Due to the characteristic strong phenotype of hybrid necrosis, it has been successful in identifying DANGEROUS MIX (DM) genes in Arabidopsis thaliana, consisting of two incompatible immune …
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Platforms for exploring host-pathogen interactions in hepatitis C virus infection
… central to HCV infection, including innate immune signaling, polarization, and proliferation. Third, infection is typically studied using bulk assays with suboptimal specificity, sensitivity, and content. Here, we describe three technologies for overcoming these limitations in the study of …
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Liquid-Liquid Phase Separations in Innate Immune DNA Sensing and NF-κB Signaling Pathways
… cyclic GMP-AMP (cGAMP), which activates innate immune responses. We have shown that DNA binding to cGAS robustly induced the formation of liquidlike droplets in which cGAS was activated. The disordered and positively charged cGAS N terminus enhanced cGAS-DNA phase separation by increasing the …
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Investigating NLR-mediated immunity and Pseudomonas syringae effector interactions with two MACPF domain proteins in Arabidopsis thaliana.
… cell to shut down key components of the plant immune signaling pathway. To protect against effector sabotage, plants have evolved intracellular NUCLEOTIDE BINDING AND LEUCINE RICH REPEAT RECEPTORS (NLRs) that monitor the integrity of critical immune signaling components likely to be effector …
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Trimming Fat Upon Infection: Proteolytic Demyristoylation as a Novel Bacterial Pathogenic Strategy
… than twenty effectors which highjack normal cell signaling by modulating activity of host proteins. By interfering with immune signaling, cytoskeleton, and other pathways, effector proteins promote survival of the bacterial pathogen. Inability to secrete effectors severely attenuates Shigella spp, …
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The Evolution of Platelet Responses to Collagen Under Conditions of Hemodynamic Flow
Collagen activates platelets through the immune-type GPVI receptor, but the mechanism by which this receptor has adapted to function in platelets under conditions of rapid blood flow is unclear. Additionally, it is unknown if responses to collagen are conserved in nucleated thrombocytes found in …
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Regulation of Antimicrobial Peptide Genes in the Tobacco Hornworm Manduca sexta
The innate immune system, also known as natural or non-specific immune system, is conserved from insects to humans. The insect innate immune system is composed of humoral and cellular components. Insect humoral responses mainly include synthesis of antimicrobial peptides (AMPs) and activation of …
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Explorations of DNA-Single-Walled Carbon Nanotube Interactions to Develop Multiplexed Molecularly Specific Biosensors for Inflammation
… interleukin-12 (IL-12) are central regulators of immune signaling and key biomarkers of disease, yet existing assays for their detection remain slow, invasive, and lack multiplexing ability. This dissertation advances the development of single-walled carbon nanotube (SWCNT) optical nanosensors …
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Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
<p>Glycosylation of immune receptors and ligands, such as T-cell receptor (TCR), major histocompatibility complex (MHC), and co-inhibitory molecules, regulates immune signaling activation, antigen presentation, and immune surveillance. Recent studies revealed that the glycan structures of …
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The Tumor-Suppressive Properties of Neural Stem Cells
… nervous system malignancy that commonly causes immune suppression in patients to avoid immune recognition and clearance. This complicates treatment options and limits the effectiveness of immunotherapy strategies. Interestingly, GBM formation can stimulate the neurogenic subventricular zone of …
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