Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"immune response genes"”.
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Isolation of innate immune response genes, expression analysis, polymorphism identification and development of genetic markers for linkage analysis in common carp (Cyprinus carpio)
… aquaculture stock, several candidate genes for antiviral innate immune response from common carp were isolated, and single nucleotide polymorphisms (SNPs) were identified. SNP markers for common carp immune response genes were developed for testing their linkage to disease resistance …
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Molecular Classification of Basal Cell Carcinoma of Skin by Gene Expression Profiling
… By contrast, the SCC-like BCC was enriched with immune-response genes and oxidative stress-related genes. Network analysis revealed the PLAU/PLAUR as a key regulator of SCC-like BCC. The normal-like BCC showed prominent activation of metabolic processes particularly the fatty acid metabolism. The …
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Analysis of the Allergenic Potential of the Ubiquitous Airborne Fungus Alternaria Using Bioinformatics
… has been proven that an abnormal immunological response to Alternaria most likely contributes to the pathogenesis of upper respiratory airway disorders. In this body of work, we present for the first time results of several sets of experiments including, 1) the analysis of A. alternata spore …
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Mechanism of Ubiquitin Induced Activation of RIG-I Like Receptors in Antiviral Innate Immunity
The innate immune response is the first line of defense against viral infections. Innate immune recognition is mediated by a set of host pattern recognition receptors that can recognize pathogen associated molecular patterns, and trigger the expression of immune response genes. Two proteins of the …
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Quantifying expression variability in single-cell RNA sequencing data
… mammalian development, tissue homoeostasis and immune function. While expression heterogeneity, a phenotypic readout of transcriptional noise, has been broadly studied in prokaryotic model systems or by profiling individual genes, few whole-transcriptome studies in mammalian systems have been …
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Human Immunodeficiency Virus/Human Papillomavirus co-infection and host molecular genetics of cervical carcinoma
… viral peptides are recognized by the host immune system. It is reasonable to propose that the development of viral-associated cancers, like cervical cancer, requires interference with specific immune-response genes. This thesis investigates this proposition with consideration of host …
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Gene expression analysis in breast cancer
… samples was analysed to identify important genes and pathways relevant to various clinical parameters. Our results identified groups of patients with similar expression profiles, the possible biology driving them and the clinical implications. Comparing Normal and Cancer specimens’ gene …
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Comprehensive gene assessment of estrogen receptor positive breast cancers reveals that HER2 positive status plays an important role in resistance to neoadjuvant letrozole
… with neoadjuvant Letrozole had their clinical response assessed using periodic 3D ultrasound. Core biopsies were taken at 0, 14 days and 3 months of treatment. RNA was extracted, amplified, labelled and hybridised to Illumina HT-12 whole genome beadarrays. A group of patients with ER positive/ …
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Gene expression during the host-bacteria interaction
… dramatically upon their interaction. This response is shaped by the co-evolutionary arms race where the host seeks to detect and counter the invading pathogen, whilst the pathogen aims to evade this response and modify the host to better suit its survival and replication. Changes in gene …
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Understanding functional mechanisms of genetic susceptibility to mycobacterial infection
… association studies (GWAS) aim to discover human genes associated with susceptibility to TB. Recently, a GWAS conducted by our lab identified a new TB-associated gene ASAP1 that encodes an Arf GTPase-activating protein (GAP). ASAP1 is known to be involved in regulation of actin and membrane …
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Innate immunity in defence against infection and tissue repair of the urinary tract
… disease. A complex network of tissue-resident immune cells exists throughout the urinary tract that are vital for initiating and propagating local immune responses, however our understanding of their nature and function remains incomplete. In this thesis, we aim to understand two broad areas of …
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Comparative analysis of African and Asian/American Zika virus strains at the transcriptional and translational level
… analysis was performed in which cellular genes that were differentially transcribed by using the RNA-Seq datasets, but also the genes that had a different translational efficiency by using the Ribo-Seq datasets in response to infection with different ZIKV strains were thoroughly analysed. …
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Diversity and role of bacterial endosymbionts infecting the cassava whitefly, Bemisia tabaci (Gennadius) in Sub-Saharan Africa
… those infected with bacteria. However, innate immune response genes were upregulated in AR+ than AR- populations, possibly indicating a protective role of bacterial infections in AR+ whiteflies against pathogenesis. Endosymbiotic bacteria infecting cassava whiteflies during the Uganda cassava …