Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1752 for “"immune response"”.
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GP96 and the immune response
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.
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The immune response in Q fever.
Contains fulltext : 145305.pdf (Publisher’s version ) (Open Access)
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Substance P And The Host Immune Response
<p>This body of work examined the mechanism by which SP regulates host immunity, specifically, its control of growth factors and TLR expression in the P. aeruginosa-infected cornea. The role of mTOR and VIP in corneal infection and inflammation also was tested.</p> <p>SP has a dual role in …
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Modulation of the CRISPR-Cas9 Immune Response
… where both must continually adapt to survive. In response, bacteria have developed numerous immune systems to protect themselves, including CRISPR-Cas. CRISPR-Cas systems provide adaptive immunity through the acquisition of short DNA sequences from invading phages, known as spacers. Spacers are …
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The inducible antiviral immune response of Drosophila melanogaster
In der vorliegenden Arbeit wurde Drosophila melanogaster als Modell ge- nutzt, um die angeborene Immunantwort gegen virale Infektionen zu studie- ren. Wir untersuchten mit Hilfe von genomweiten microarrays das Transkriptom von Fliegen, welche entweder mit dem Drosophila C Virus (DCV), dem Flock- …
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CHARACTERIZATION OF IMMUNE RESPONSE IN EXPERIMENTAL MOUSE MODELS
This PhD research project aimed to investigate immune system functions in healthy and pathologic experimental murine models, through immunohistochemical characterization of immune cell populations in healthy steady state, inflammatory and neoplastic settings. The following fields were investigated: …
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Modeling the dynamics of the plant immune response
… profiled as dynamic snapshots of biological responses. My PhD study focuses on dynamic modeling of plant immunity, a plant defense response induced by pathogens. There are two well-defined modes of inducible immunity of plant to overcome pathogen attack, namely pattern triggered immunity …
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Haemophilus influenzae adhesins and the innate immune response
… mediators play an important role for the innate immune response and the recruitment of neutrophils. Finally, PE promotes bacterial invasion into epithelial cells. In summary, the work presented in this thesis shows that Hsf may prolong the bacterial survival by interacting with the complement …
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Mathematical Modelling of the Immune Response to Cancer
The immune system’s vitality and function is of the upmost importance in the human body. The ingenuity and performance of this defence mechanism also plays a role in the prevention of mutated, transformed cells becoming malig- nant tumours (cancers). More recently, the subject of cancer immunology …
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Regulation of gene expression in macrophage immune response
… specific. This is particularly relevant for immune cells, whose cellular function and behaviour can be substantially altered by external cues. Furthermore, understanding mechanisms behind eQTLs is hindered by the difficulty of identifying causal variants. We differentiated macrophages from …
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Mathematical Modelling and Statistical Inference from Immune Response Data
A hallmark of the adaptive immune response is the proliferation of pathogen-specific lymphocytes that leave in their wake a long lived population of cells that provide lasting immunity. A subject of debate is at which time point post infection those memory cells are produced during an adaptive …
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Structural Investigation of Bacterial Pathogenesis and Host Immune Response
… lack of mobile defender cells and an adaptive immune system, plants have relied exclusively on the innate immunity of individual cells and on systemic signals emanating from the infection sites (Dodds & Rathjen, 2010). NPR1 (NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1) is a master immune …
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The Control of Cell Division During the Immune Response
… immunization with antigen a proliferative response was detected in both the bone marrow and spleen. Concomitant with this heightened proliferative activity there occurred a significant hypercalcaemia. The elevated proliferation was always associated with a hypercalcaemic episode regardless …
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
… The form and functionality of this adaptive immune reaction and why it fails when cancer develops remain unclear. In this work, I have studied the adaptive immune response to senescence using in vitro and in vivo models. I have used hydrodynamic tail vein (HDTV) delivery of …
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Mycobacterial strain diversity : impact on the host immune response
Bibliography: p. 169-207.
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Disruption of Dna Polymerase Zeta Promotes An Innate Immune Response
… loss of pol ζ promotes activation of an innate immune response.</p> <p><em>Rev3l </em>knockout MEFs had over 1000 genes that were either upregulated or downregulated more than 4-fold. Importantly, this revealed that loss of <em>Rev3l</em>induced an increase in expression of known …
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Gender Differences in Depression and Immune Response in Colorectal Cancer
… relationship between gender and depression and immune system function in patients with colorectal cancer. The research questions were answered through secondary analysis, using data obtained from the answers of 117 men and women (71 men and 46 women) enrolled in a colorectal cancer study …
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New Targets of p53 Regulation: From Aging to Immune Response
… stimuli into changes in gene expression. In response to mechanical stimuli, p53 may alter components of the extracellular matrix and chromatin. This change in the spatial organization of the nucleus may be an additional mechanism by which p53 promotes changes in gene expression patterns. In …
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