Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"immune modulation"”.
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Engineering therapeutic proteins for immune modulation
… and inhibitory Fc[gamma]Rs are expressed on immune cells and bind to the Fc regions of IgGs, which either promote or hinder responses against the tumor cell. Since mouse models of cancer are currently the most established in this field, studying the effect of modulating individual murine …
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Astrocyte-mediated immune modulation during mycobacterial infection
… Little is known about the cells that regulate immune responses during CNS-TB infection. Microglia are the prime resident immune-effector cells in the CNS; astrocytes however also regulate innate and adaptive immunity in CNS disease and injury. Astrocytes play a progressive role in maintaining …
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Immune Modulation of The Mycobacterium Tuberculosis Granulomatous Response
… to the action of antibiotics. Additionally, immune-mediated tissue destruction likely facilitates disease transmission. The granulomatous response is in part due to mycobacterial glycolipid antigens. Therefore, studies were first undertaken to determine the innate mechanisms of mycobacterial …
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Non-viral drug delivery systems for immune modulation
… apply these delivery systems to modulating the immune system. We optimized particle formulations for the delivery of three novel immune modulating compounds, small inhibiting RNA, immunostimulatory RNA, and 3-1,6-glucan. Because microparticles formulated from PLGA and Poly(3-amino-ester) have …
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Immune modulation mechanisms of porcine circovirus type 2
… areas of research, but it is thought that host immune modulations by PCV2 or a co-infecting pathogen are critical in the pathogenesis of PCVAD. In the first study of this dissertation the ability of PCV2 to induce regulatory T-cells (Tregs) and alter cytokine production was evaluated in vivo. …
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Targeting T Cells for the Immune-Modulation of Human Diseases
… represent a compelling target population for immune-modulation. In fact, the antigen-specificity, cytotoxicity and promise of long-lived of immune-protection make T cells ideal vehicles for cancer immunotherapy. Interventions for autoimmune disorders, on the other hand, aim to dampen T …
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Improving cancer therapy strategies via cellular stress and immune modulation
… significant progress in molecularly targeted and immune-based therapies, metastatic and chemoresistant cancers continue to exhibit poor clinical outcomes. This dissertation investigates two distinct therapeutic strategies designed to overcome tumor resistance and improve therapeutic efficacy. The …
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Innate immune modulation and pathogenic basis for porcine reproductive and respiratory syndrome virus
… study dissects the molecular basis of innate immune suppression and NF-kB activation of PRRSV and identifies the leucine 126 of nsp1β and NLS of N are essential residues. The innate immune modulation and NF-kB activation together delineate the pathogenic basis of PRRSV.
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An assessment of medicinal hemp plant extracts as natural antibiotic and immune modulation phytotherapies
This study aimed to evaluate the antimicrobial efficacy of medicinal hemp plant extracts to determine the antibacterial effects of indigenous Sansevieria species and exotic Cannabis sativa phytotherapy varieties. This study also assessed whether aqueous o
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An assessment of Hypoxis hemerocallidea extracts, and actives as natural antibiotic, and immune modulation phytotherapies
In South Africa, the crude aqueous extract from Hypoxis hemerocallidea is used by AIDS patients to treat opportunistic infections, such as tuberculosis. The rapid emergence of multidrug-resistant tuberculosis, and extreme drug resistant tuberculosis, in recent years, is a major threat to human …
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Counteracting Neuroinvasive RNA Viruses: Antiviral and Immune Modulation Strategies Against SARS-CoV-2 and VEEV
The global response to the COVID-19 pandemic and our inability to mitigate spread of SARS-CoV-2 has highlighted areas of research that warrant further study. RNA viruses have since been at the forefront for pandemic and prevention preparedness due to their increased potential to cause future …
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Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide
… T cells (iNK-T cells) are a powerful regulatory immune cell that can recruit both innate and adaptive immune cells. Unlike conventional T cells (CD4<sup>+ </sup>and CD8α<sup>+</sup>), they recognize glycolipid antigens via the MHC-class-I like molecule, CD1d. A synthetically derived glycolipid …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
… highlighting a need for greater understanding of immune regulation by lymphatics. The specific role of lymphatic endothelial cells (LECs) in this context, particularly in TDLNs, is unknown. As TDLNs are immune hubs, yet anti-tumour immune responses are often ineffective, this thesis aimed to …
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Pathogenic roles of Pseudomonas aeruginosa-derived volatile organic compounds in airway mucus hypersecretion: Molecular mechanisms and immune modulation
This Dissertation was approved for publication on 2024-12-04 at 14:52.
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Exploring Host-Pathogen Interactions: Tracking SARS-CoV-2 evolution and assessing immune modulation exerted by Staphylococcus aureus membrane vesicles
L'evoluzione rapida dei virus a RNA e il ruolo delle vescicole di membrana batteriche (MVs) nelle interazioni ospite-patogeno rappresentano ambiti di ricerca cruciali nelle malattie infettive. Questo studio combina due indagini distinte: l'evoluzione di SARS-CoV-2 e l'impatto immunologico delle MVs …
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Modulation of Neutrophil Functions by Neurotransmitters Implicated in Stress
<p>Stress has long been implicated in immune modulation. People under chronic stress have no change in the circulating basal levels of catecholamines while plasma levels of neuropeptide Y (NPY) are significantly increased. Sympathetic nerve fibers with NPY have been found to innervate immune …
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Designing Immune-Instructive Biomaterials: The Interplay of Biomaterial surface, IgG Unfolding, and Macrophage Modulation
… how biomaterials can be designed to guide the immune system’s response in beneficial ways. By studying how the immune system interacts with different model implant materials, the work reveals strategies to modulate immune response, promote healing and improve the integration of medical …
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A Dual-Domain Peptide Strategy for Targeted Regenerative Repair
… coordinated extracellular matrix targeting and immune modulation. The peptide construct incorporates a collagen-binding domain (CBD) to spatially localize bioactivity within matrix-rich tissues. Two alternative CBDs are investigated: a DMP1-derived acidic motif (CBD1: DSESSEEDR) and a …
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Effect of Relaxation on Neuro-Immune Responses of Persons Undergoing Chemotherapy
… can result in down-regulation of certain immune functions. Studies have demonstrated that behavioral interventions, such as specific relaxation strategies, can modify stress-related immune modulation. These behavioral interventions have also been shown to decrease the degree of nausea and …
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Nutrient Sensing in Immune Function: A Systems Biology Approach
… disease. Studies have highlighted the immune-modulatory and anti-inflammatory effects of nutrient deprivation, suggesting a critical role for metabolic and mitochondrial function on immune activity. To explore the mechanisms underlying these effects, we have carried out a clinical study …
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