Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"immune mediators"”.
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Immune Mediators of Murine Lyme Arthritis
Lyme disease is the most common vector-borne disease in both the United States and Europe; however, its pathogenesis is incompletely understood. The studies described in this thesis aid in the elucidation of mechanisms regulating murine Lyme arthritis and may suggest mechanisms by which human Lyme …
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Uterine immune mediators and lipid profiles of the preimplantation embryo and endometrial tissue in Holstein cows supplemented with rumen-protected methionine and observed neutrophil extracellular trap (NET) formation in the bovine endometrial tissue
Future reproductive success of the dairy industry continues to decline as the push for high-producing dairy cows increases. The transition from gestation into early lactation can be stressful for the dairy cow and result in low fertility in the future. Implementation of feed strategies can improve …
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On Complications to Cataract Surgery
… (IOL) dislocation – and to analyze inflammatory mediators in the vitreous of phakic (no previous cataract surgery) and pseudophakic (previous cataract surgery with IOL) eyes. Methods: Paper I is a multicenter case-control study evaluating the incidence and outcome of RD in eyes experiencing a …
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Investigation of differential TNFα-induced interleukin-6 gene regulation by synthesis progestins medroxyprogesterone acetate (MPA) and norethindrone acetate (NET-A) in human endocervical epithelial cells and the role of the unliganded glucocorticoid receptor
… but they also express a wide variety of immune mediators. The endocervical epithelial cells express a distinct profile of immune-regulators, which is higher than vaginal and ectocervical epithelial cells. Constant cytokine production would ensure rapid responses to infections and …
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Single cell landscape of innate and adaptive immunity in metastatic melanoma treated with immunotherapy
Immune checkpoint inhibitors (ICIs) have revolutionized the care for cancer and extended survival for many patients. While ICIs have shown astonishing clinical benefits, less than 50% of patients experience a durable response. To find better biomarkers for ICI response and understand the diverse …
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Characterization of Alpha-Galactosylceramide As A Mucosal Adjuvant
… of vaccine formulations that enhance adaptive immune responses to antigens, particularly for immunizations targeting the tolerogenic mucosal tissues, which are more biologically relevant for protective immunity against pathogens transmitted by the mucosal routes. Adjuvants possess the inherent …
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The Expression and Cellular Localization of Cc-Chemokine Receptor 5 (Ccr5) After Traumatic Brain Injury
… to the site of injury where these cells secrete immune mediators such as cytokines and chemokines. CC-chemokine receptor 5 (CCR5) is a member of the CC chemokine receptor family of seven transmembrane G protein coupled receptors. CCR5 is expressed in the immune system and is found in monocytes, …
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The Expression and Cellular Localization of Cc-Chemokine Receptor 5 (Ccr5) After Traumatic Brain Injury
… to the site of injury where these cells secrete immune mediators such as cytokines and chemokines. CC-chemokine receptor 5 (CCR5) is a member of the CC chemokine receptor family of seven transmembrane G protein coupled receptors. CCR5 is expressed in the immune system and is found in monocytes, …
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Regulation of Intestinal Epithelial Thymic Stromal Lymphopoietin Gene Expression by Retinoic Acid Receptor Alpha
… is thought to be due to a dysregulated immune response to intestinal microbiota. Approximately 15% of the risk is genetically linked and approximately 85% is attributed to environmental exposures. Dietary factors like retinoic acid (RA), a vitamin A metabolite, have been linked to the …
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T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses
… stages of development are required, as the immune system undergoes massive changes from gestation through the end of adolescence, and 2) the complex nature of pediatric research decreases the availability of robust and comprehensive studies. Importantly, studying the immune system in …
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The Role of the IL-23/Th17/IL-17 Axis in the Pathophysiology of Endometriosis
… EM etiology and pathogenesis remain unclear, immune dysfunction is recognized to enable lesion establishment and progression. Notably, the IL-23/Th17/IL-17 axis is significantly altered in EM and associated with disease severity. This is notable as in other chronic inflammatory diseases, IL-23 …
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Mechanisms of atopic dermatitis and allergy development in African (AmaXhosa) children between 12-36 months of age
… independent of AD, a vast array of circulating immune mediators (including proinflammatory cytokines, chemokines, soluble adhesion molecules and growth factors) were associated with early life nutrition, medications, animal exposures, indoor environment, sunlight exposure and household size. RNA …
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Importance of specific NK cell subsets for antitumor immunity in HPV+ cancers
… (SOC) treatment. Identifying the antitumor host immune mediators important for treatment response and designing strategies to promote them are essential for improving clinical outcome. The natural killer (NK) cells are a critical component for antitumor innate effector immunity. Among the …
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Effects of Carboxylated Nanodiamonds on Macrophages During and After Differentiation
… cells and systems. The effects of ND on the immune system are not fully understood or investigated and there are several controverting reports regarding ND biocompatibility. Macrophages are found in almost all tissues of the body and are key players in the vertebrate immune system, …
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Effect of HIV infection and pregnancy on parameters of vaginal immunity
… of factors contributing to the cervicovaginal immune environment. Like with systemic immunity, innate and adaptive immune mediators are integrated in the efficiency for fighting infections in the female genital tract. Our study addresses the role of pregnancy and HIV infection on concentrations …
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The role of host and microbial factors in the pathogenesis of chronic schistosomiasis in mice
… microbiota, host's genetic factors, and immune response during helminth infections which are still poorly understood. The study explores this relationship in the context of chronic schistosomiasis-driven pathology. In the first part of the thesis, removal of the host Basic Leucine Zipper …
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Inflammatory Breast Cancer: The Immune Perspective
… is known about the role of inflammation or immune mediators in IBC. Therefore, we analyzed blood samples from IBC patients and non-IBC patients, as well as healthy donor controls to establish an IBC-specific profile of peripheral blood leukocyte phenotype and function of T cells and …
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Mechanisms of microbial-host interaction during asymptomatic bacteriuria
… samples from the patients were screened for 31 immune markers. The genetic polymorphisms in the interferon regulatory factor 3 (IRF3) and Toll-like receptor 4 (TLR4) promoter had a significant impact on the magnitude of the host response during E. coli 83972 ABU, which consisted of mainly innate …
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Modeling steric effects in antibody aggregation using rule-based methods
… allergic response is produced by the release of immune mediators by mast cells and basophils. This process, in turn, is initiated by the aggregation of antigens and IgE-FcεRI antibody-receptor complexes. Computational modeling of antibody- antigen aggregate formation as well as the size and …
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