Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"immune markers"”.
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Maternal Serum and Whey Immune Markers and Eczema Among Infants
… and its relation to maternal whey and serum immune markers are considered to either de- or increase risk of the skin disorder. We conducted a prospective study to contrast the role of different maternal immune markers (MIMs) in maternal serum and whey on the development of eczema symptoms in …
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Gastrointestinal dysfunction in Parkinson’s disease: Interactions between the gut, immune markers and disease outcome
… nervous system. These gut changes may trigger an immune activation response which accelerates disease progression. Despite an exponential growth of research efforts on the mechanisms of the gut-brain axis’ role in the pathophysiology of PD, a comprehensive characterization of GID-PD and an …
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The Modulation Of Mucosal Immune Markers, Urs, And Psychological Parameters Following Acute And Chronic Exercise
… was to evaluate changes in two antimicrobial markers, upper respiratory symptom (URS) variables, and mood state following participation in an acute (N = 93) and chronic (N = 88) observational study of college aerobic exercise, yoga exercise, and non-exercise classes. </p> <p> …
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Maternal body mass index and proinflammatory immune markers in HIV-infected pregnant woman on antiretroviral treatment in Cape Town, South Africa
… inflammation during pregnancy. Proinflammatory immune markers during pregnancy and the impact of maternal BMI in WLWH initiating ART in pregnancy or preconception will be evaluated. Methods. In this mini-dissertation is a protocol (Part A), journal formatted manuscript (Part B) and Appendices …
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Maternal Immune Markers In Serum During Late Gestation and In Breast Milk and the Risk of Asthma-Like Symptoms At Ages 6 and 12 Months: A Longitudinal Study
… study are to determine the relationship of immune markers in maternal serum during gestation and breast milk to asthma-like symptoms (AS) in infancy, and the association between fatty acids (FAs) in colostrum and breast milk with AS and atopy. A second goal is to conduct cluster analyses to …
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An investigation of a neuro-inflammatory profile of HIV-associated neurocognitive disorders
… (PLWH), regardless of treatment status. Chronic immune dysregulation has been associated with HAND; in particular, it has been noted that inflammation persists despite the successful treatment with antiretroviral therapy (ART). However, the nature to which (neuro)inflammation influences cognitive …
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Creating a Marked Mycobacterium avium subsp. paratuberculosis Vaccine Strain and Detecting Marker-Specific Immune Responses in Calves
… To remediate this issue, positive and negative immune markers were inserted into a field strain of MAP as part of a vaccine capable of differentiating infected from vaccinated animals (DIVA). Specialized transducing mycobacteriophages were used to replace a gene coding for an immunogenic protein …
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Microbiota-gut-immune-brain communication across the lifespan
… aging, along with the development of better biomarkers towards the development of personalized therapeutic strategies. In this thesis, we aimed to investigate the influence of the gut microbiome in immune and behavioural features throughout the lifespan of the host: in early-life and aging. To …
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Functional neuroimaging studies of peripheral inflammation-related depression
… in the traditional sense, i.e., biological markers. Depression is difficult to characterize in that it is highly heterogeneous epidemiologically and symptomatically. Depression is often a comorbidity, associated with other physical or mental health disorders, and depressive symptoms occur on …
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Insights from serological surveillance in infectious disease epidemiology
… Serological surveillance, which tests for immune markers such as antibodies generated in response to an infection, provides invaluable information relating to the underlying burden and dynamics of infectious diseases. In this thesis I developed and applied analytical methods to maximize …
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Genomic aberrations as determinants of immune infiltrates in high grade serous ovarian carcinoma
… indicating the prognostic significance of immune cell abundance in high grade serous ovarian cancer (HGSOC), mutational processes by which tumours gain immunogenicity or develop immune evasion are yet to be identified. Mutational processes that play a key role in HGSOC tumourigenesis leave …
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Immune biomarkers of clinical outcome in patients with major trauma
… contributing to significant mortality. The immune response to trauma is postulated to follow a ‘two-hit’ course, with clinical outcomes being dictated through a complex interplay between cascades of systemic pro-inflammatory and compensatory anti-inflammatory responses (SIRS and CARS). The …
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Comparing live to recorded music and stories using multiple psychoneuroendocrine and psychological measures
… science of saliva analysis, which focuses on biomarkers that indicate stress and immune function. In this case salivary cortisol, alpha-amylase, immunoglobulin-A, interleukin- 1beta, and pH levels were measured. Saliva samples from 50 university students and 23 palliative care and surgical …
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Tail-biting in growing-finishing pigs with intact tails: evaluating group size and litter origin
… risk and highlights the potential utility of immune markers for identifying pigs predisposed to biting. Finally, data across both projects were integrated to evaluate the spatiotemporal context of outbreaks. Tail-biting events occurred most frequently in the central pen area, typically when …
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Mechanisms of microbial-host interaction during asymptomatic bacteriuria
… samples from the patients were screened for 31 immune markers. The genetic polymorphisms in the interferon regulatory factor 3 (IRF3) and Toll-like receptor 4 (TLR4) promoter had a significant impact on the magnitude of the host response during E. coli 83972 ABU, which consisted of mainly innate …
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
… to diagnose clinically. This thesis focuses on immune thrombocytopenia (ITP), a disorder marked by immune-mediated platelet destruction and impaired thrombopoiesis. Patients with ITP display heterogeneous clinical trajectories and bleeding severity, often poorly correlated with platelet count, …
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Effect of fatty acids and programming on the immune system
… suggested that fatty acids (FAs) may affect the immune system, through their (and those of their metabolites) effects on membranes, mediators, and gene expression. However, despite the research carried out, there still exist gaps of knowledge where further research is required. In addition, …
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The association of maternal HIV status during pregnancy on longitudinal neuro-immune regulation, and neurodevelopment in HIV-exposed uninfected children
… (HIV) and its effects, such as its impact on the immune system and then the numerous consequences on other biological systems including the central nervous system (CNS), have had a significant effect worldwide. This is particularly relevant in South Africa, where the prevalence of adults living …
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TRANSLATIONAL RESEARCH TARGETING BILIARY TRACT CANCER
… treatment against CCA, the exploration of the immune background of GBC, and the establishment of a CCA mouse model mimicking mutation profiles of CCA patients.</p> <p>Patients with cholangiocarcinoma have poor clinical outcomes due to late diagnoses, poor prognoses, and limited treatment …
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Immune biomarkers predicting clinical outcomes for major trauma patients
… trauma worldwide. Ongoing research exploring the immune response to trauma over the years has highlighted the systemic inflammatory response syndrome (SIRS) as an early immune response to trauma. Driven mainly via macrophages and innate immune cells, this response is followed by the counter …
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